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User:Synpath/sandbox

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Template Test

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infobox copied from Vitamin E to test adding ImageClass parameter

Synpath/sandbox
Drug class
The RRR alpha-tocopherol form of vitamin E
Class identifiers
UseVitamin E deficiency, antioxidant
ATC codeA11HA03
Biological targetReactive oxygen species
Clinical data
Drugs.comMedFacts Natural Products
External links
MeSHD014810
Legal status

infobox copied from Morphine

Synpath/sandbox
Clinical data
Pronunciation/ˈmɔːrfn/
Trade namesStatex, MS Contin, Oramorph, others[1]
AHFS/Drugs.comMonograph
MedlinePlusa682133
License data
Pregnancy
category
Dependence
liability
High
Addiction
liability
High[3]
Routes of
administration
Inhalation (smoking), insufflation (snorting), by mouth, rectal, subcutaneous, intramuscular, intravenous, epidural, intrathecal
Drug classOpiate
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability20–40% (by mouth), 36–71% (rectally),[9] 100% (IV/IM)
Protein binding30–40%
MetabolismLiver: UGT2B7
MetabolitesMorphine-3-glucuronide (90%)
Morphine-6-glucuronide (10%)
Onset of action5 minutes (IV), 15 minutes (IM),[10] 20 minutes (PO)[11]
Elimination half-life2–3 hours
Duration of action3–7 hours[12][13]
ExcretionKidney 90%, bile duct 10%
Identifiers
  • (4R,4aR,7S,7aR,12bS)-3-Methyl-2,3,4,4a,7,7a-hexahydro-1H-4,12-methano[1]benzofuro[3,2-e]isoquinoline-7,9-diol
CAS Number
  • 57-27-2 checkY
    64-31-3 (neutral sulfate),
    52-26-6 (hydrochloride)
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
PDB ligand
Chemical and physical data
FormulaC17H19NO3
Molar mass285.343 g·mol−1
3D model (JSmol)
Solubility in waterHCl & sulf.: 60
  • CN1CC[C@]23C4=C5C=CC(O)=C4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5
  • InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2-5,10-11,13,16,19-20H,6-8H2,1H3/t10-,11+,13-,16-,17-/m0/s1 checkY
  • Key:BQJCRHHNABKAKU-KBQPJGBKSA-N checkY
  (verify)

Misc

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The RCSB Molecule(s) of the Month are bacterial nanowires like PDB: 7qv7, hydrogen-dependent carbon dioxide reductase (HDCR) -> https://pdb101.rcsb.org/motm/290

  • I think these should be added to Nanowire as a separate section summarizing their function and structures and hatnote to the main article Bacterial nanowires where there is no current coverage of their structure.
  • Also consider adding PDB 7xkm to Molecular wire

Natural Nanowires

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Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum.


Template Char Angbr "M"
Em space ⟨ ⟩ M M
En space ⟨ ⟩ M M
nb space   ⟨ ⟩ M M
thin space ⟨ ⟩ M M
hair space ⟨ ⟩ M M
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portals: GenomeNet EBI EMBNet

programs: PSAlign PRRN/PRRP CHAOS/DIALIGN M-COFFEE MergeAlign POA SAM MEME/MAST EDNA TCS

  1. ^ Cite error: The named reference drugs.com-page was invoked but never defined (see the help page).
  2. ^ "Morphine Use During Pregnancy". Drugs.com. 14 October 2019. Retrieved 21 August 2020.
  3. ^ Bonewit-West K, Hunt SA, Applegate E (2012). Today's Medical Assistant: Clinical and Administrative Procedures. Elsevier Health Sciences. p. 571. ISBN 978-1-4557-0150-6.
  4. ^ "Morphine Product information". Health Canada. 9 August 2005. Retrieved 4 April 2024.
  5. ^ Cite error: The named reference Black's was invoked but never defined (see the help page).
  6. ^ "Sevredol Summary of Product Characteristics (SmPC)". (emc). 13 February 2024. Retrieved 20 February 2024.
  7. ^ "MS Contin- morphine sulfate tablet". DailyMed. 27 December 2023. Retrieved 20 February 2024.
  8. ^ "Modified-released oral opioids". European Medicines Agency. 18 November 2010. Retrieved 20 February 2024.
  9. ^ Jonsson T, Christensen CB, Jordening H, Frølund C (April 1988). "The bioavailability of rectally administered morphine". Pharmacology & Toxicology. 62 (4): 203–5. doi:10.1111/j.1600-0773.1988.tb01872.x. PMID 3387374.
  10. ^ Whimster F (1997). Cambridge textbook of accident and emergency medicine. Cambridge: Cambridge University Press. p. 191. ISBN 978-0-521-43379-2. Archived from the original on 8 September 2017.
  11. ^ Liben S (2012). Oxford textbook of palliative care for children (2 ed.). Oxford: Oxford University Press. p. 240. ISBN 978-0-19-959510-5. Archived from the original on 8 September 2017.
  12. ^ Cite error: The named reference AHFS2015 was invoked but never defined (see the help page).
  13. ^ Cite error: The named reference Rockwood2009 was invoked but never defined (see the help page).