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The FDA has several approved indications for Drospirenone. It is approved as a first-line therapy for menopause symptoms such as the relief of hot flashes. ^[1]

Additionally, it has been shown to reduce the occurrence of bone fractures in postmenopausal women.  ^[2]

^ Maclennan, A. H.; Broadbent, J. L.; Lester, S.; Moore, V. (18 October 2004). "Oral oestrogen and combined oestrogen/progestogen therapy versus placebo for hot flushes". The Cochrane Database of Systematic Reviews (4): CD002978. doi:10.1002/14651858.CD002978.pub2. ISSN 1469-493X.
^ Torgerson, D. J.; Bell-Syer, S. E. (13 June 2001). "Hormone replacement therapy and prevention of nonvertebral fractures: a meta-analysis of randomized trials". JAMA. 285 (22): 2891–2897. ISSN 0098-7484.

[1] Maclennan, A. H.; Broadbent, J. L.; Lester, S.; Moore, V. (18 October 2004). "Oral oestrogen and combined oestrogen/progestogen therapy versus placebo for hot flushes". The Cochrane Database of Systematic Reviews (4): CD002978. doi:10.1002/14651858.CD002978.pub2. ISSN 1469-493X.

[2] Torgerson, D. J.; Bell-Syer, S. E. (13 June 2001). "Hormone replacement therapy and prevention of nonvertebral fractures: a meta-analysis of randomized trials". JAMA. 285 (22): 2891–2897. ISSN 0098-7484.

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