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WDR90 is a protein that in humans is encoded by the WDR90 gene (16p13.3.). Orthologs of this gene have been found in nature from mammals to protazoa and everywhere in betweem. WDR90 multiple WD transducin repeating domains that have been found to play a role in a variety of function ranging from signal transduction and transcription regulation to cell cycle control, autophagy and apoptosis. ^[1] This domain is conserved across the "ortholog space' Although there is no confirmed function of WDR90, through analyzing expression and experimental data, it is predicted that WDR90 is a hepatocellular carcinoma and cell proliferation.

Gene

Locus

The human gene WDR90 is found on chromosome 16 at the band 16p13.3.^[2]

^[3]

There are a few known isoforms because the gene has 41 exons.

Aliases

This gene has several known aliases that include C16orf15-19 as well as KIAA1924, and WD repeat domain 90. ^[4]

Homology

Paralogs

There is one known paralog for WDR90, it is called WDR16 ^[5]

Orthologs

The ortholog space of WDR90 is fairly large. It has been found in protozoa and mammals alike.

Genus and Species^[6]	Common Name	Class	Accession	Percent Identity
Pan paniscus	Bonobo	Mammalia	XP_008959157.1	99%
Camelus dromedarius	Dromendary	Mammalia	XP_010989416.1	74%
Lipotes vexillifer	Freshwater Dolphin	Mammalia	XP_007453739.1	71%
Chinchilla lanigera	Long-tailed Chinchilla	Mammalia	XP_005391679.1	70%
Myotis brandtii	Brandt's Bat	Mammalia	XP_005870439.1	68%
Alligator mississippiensis	American alligator	Reptile	XP_006262948.1	55%
Acanthisitta chloris	Rifleman	Aves	XP_009077103.1	55%
Phalacrocorax carbo	Great cormorant	Aves	XP_009499453.1	55%
Tinamus guttatus	White-throated tinamou	Aves	XP_010212226.1	54%
Pygoscelis adeliae	Penquin	Aves	XP_009318494.1	54%
Lepisosteus oculatus	Spotted gar	Actinopterygii	XP_006637148.1	48%
Oreochromis niloticus	Nile talapia	Actinopterygii	XP_005448293.1	48%
Oryzias latipes	Japanese rice fish	Actinopterygii	XP_004080577.1	47%
Takifugu gigantea	Pufferfish	Actinopterygii	XP_003961493.1	47%
Xiphophorus maculatus	Southern platyfish	Actinopterygii	XP_005803344.1	50%
Ciona intestinalis	Sea tunicate	Invertebrate	XP_009858154.1	54%
Saccoglossus kowalevskii	Acorn worm	Invertebrate	XP_791337.3	47%
Strongylacentrotus putputatus	Sea Urchin	Echinoidea	XP_795452	45%
Oxytricha trifallax	Cilliate Protozoan	Invertebrate	EJY65757.1	30%
Stylonychia lemnae	Stylonychia	Invertebrate	CDW84905.1	28%

Protein

Primary sequence

The gene encodes a protein also called WDR90. The length of the mRNA sequence for this gene is 5250 base pairs, while the number of protein coding base pairs is 1750. The coding protein has a predicted molecular weight of 187.7 kDal. This protein is leucine, valine, and alanine rich and asparagine and methionine poor when compared to other human proteins.

Domains and motifs

WDR90 contains one characterized domain of unknown function called DUF667, as well as 19 WD repeat domains.

Post-translational modifications

Software predicted sites for post-translational modifications, but none of the results can be validated beyond computer predictions.

Secondary Structure

WDR90 is predicted to have one transmembrane region that spans 23 amino acids. The WD40 repeat family is known to adopt a 7-bladed beta-propeller fold, and this was repeated through the predictive computing of Phyre2, JSmol, and SWISS-MODEL.

Expression

Transcript variants

Function

Interacting proteins

Transcription factors

Interactions

References

1. Stirnimann Christian U, Petsalaki Evangelia, Russell RB, Müller CW (May 2010). "WD40 proteins propel cellular networks.". Trends Biochem. Sci. 35 (10): 565–74. doi:10.1016/j.tibs.2010.04.003. PMID 20451393.

^ 1
^ Martin J, Han C, Gordon LA, Terry A, Prabhakar S, She X, Xie G, Hellsten U, Chan YM, Altherr M, Couronne O, Aerts A, Bajorek E, Black S, Blumer H, Branscomb E, Brown NC, Bruno WJ, Buckingham JM, Callen DF; et al. (December 2004). "The sequence and analysis of duplication-rich human chromosome 16". Nature. 432 (7020): 988–94. doi:10.1038/nature03187. PMID 15616553. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
^ Dib C, Fauré S, Fizames C, Samson D, Drouot N, Vignal A, Millasseau P, Marc S, Hazan J, Seboun E, Lathrop M, Gyapay G, Morissette J, Weissenbach J (1996). "A comprehensive genetic map of the human genome based on 5,264 microsatellites". Nature. 380 (6570): 152–4. doi:10.1038/380152a0.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ http://www.genecards.org/cgi-bin/carddisp.pl?gene=WDR90
^ http://www.genecards.org/cgi-bin/carddisp.pl?gene=WDR16
^ Cite error: The named reference Altschul_1990 was invoked but never defined (see the help page).

[1] 1

[pmid15616553-2] Martin J, Han C, Gordon LA, Terry A, Prabhakar S, She X, Xie G, Hellsten U, Chan YM, Altherr M, Couronne O, Aerts A, Bajorek E, Black S, Blumer H, Branscomb E, Brown NC, Bruno WJ, Buckingham JM, Callen DF; et al. (December 2004). "The sequence and analysis of duplication-rich human chromosome 16". Nature. 432 (7020): 988–94. doi:10.1038/nature03187. PMID 15616553. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)

[pmid-3] Dib C, Fauré S, Fizames C, Samson D, Drouot N, Vignal A, Millasseau P, Marc S, Hazan J, Seboun E, Lathrop M, Gyapay G, Morissette J, Weissenbach J (1996). "A comprehensive genetic map of the human genome based on 5,264 microsatellites". Nature. 380 (6570): 152–4. doi:10.1038/380152a0.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[4] ttp://www.genecards.org/cgi-bin/carddisp.pl?gene=WDR90

[5] ttp://www.genecards.org/cgi-bin/carddisp.pl?gene=WDR16

[Altschul_1990-6] Cite error: The named reference Altschul_1990 was invoked but never defined (see the help page).

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