User:Rodr3516/Mucoprotein
 | This is the sandbox page where you will draft your initial Wikipedia contribution.
If you're starting a new article, you can develop it here until it's ready to go live. If you're working on improvements to an existing article, copy only one section at a time of the article to this sandbox to work on, and be sure to use an edit summary linking to the article you copied from. Do not copy over the entire article. You can find additional instructions here. Remember to save your work regularly using the "Publish page" button. (It just means 'save'; it will still be in the sandbox.) You can add bold formatting to your additions to differentiate them from existing content. |
Article Draft
[edit]Function
[edit]Mucoproteins are the proteins that make up mucus, which serves as a protective barrier to the epithelia of cells. It is semipermeable, so it acts as a barrier to most bacteria and pathogens, while allowing for the uptake of nutrients, water, and hormones.[1]
Protein Structure
[edit]Mucoproteins are composed of o-linked carbohydrates as well as highly glycosylated proteins, which are held together by disulfide bonds[2]. The viscosity of the mucus depends on the strength of the disulfide bonds. When these disulfide bonds are broken, the viscosity of the mucus secretions is reduced.
Clinical Significance
[edit]Mucolytic medications will break through the disufide bonds and lower the viscosity of the mucus, thus allowing the hypersecreted mucus to bemore managable. A hypersectretion of mucus is often a symptom of pulmonary diseases or respiratory infections.[3]
There are two subgroups in mycolytic medications and each one works differently to control the hypersecreted mucus.
- Classic mucolytic medications these medications change the disulfide bond by reducing it to a thiol bond, thus thoroughly breaking down the mucoproteins and making the mucus more managable.
- Peptide mucolytic medications these medications depolymerize DNA polymer and F-actin links that are present when the mucus hypersecretes. This preserves the mucins that are helpful to the epithelial tissue of the lungs.[4]
Bibliography
[edit]- Aksoy, Murat; Aydin Faruk; Guven, Suleyman; Kart, Cavit; Tosun, Ilknur (2012). "The effect of ethinyl estradiol and drospirenone-containing oral contraceptives upon mucoprotein content of cervical mucus." ScienceDirect. [2]
- Aronson, J. K., ed. (2016-01-01). "Acetylcysteine", Meyer's Side Effects on Drugs (Sixteenth Edition), Oxford: Elsevier, pp 23-25.[3]
- Gupta, Rishab; Wadhwa, Roopma (2022). "Mucolytic Medications." National Library of Medicine.[4]
- Cone, Richard A (2009). "Barrier properties of mucus." ScienceDirect.[1]
References
[edit]- ^ a b Cone, Richard A. (2009-02-27). "Barrier properties of mucus". Advanced Drug Delivery Reviews. 61 (2): 75–85. doi:10.1016/j.addr.2008.09.008. ISSN 0169-409X.
- ^ a b Aksoy, Murat; Guven, Suleyman; Tosun, Ilknur; Aydın, Faruk; Kart, Cavit (2012-09-01). "The effect of ethinyl estradiol and drospirenone-containing oral contraceptives upon mucoprotein content of cervical mucus". European Journal of Obstetrics & Gynecology and Reproductive Biology. 164 (1): 40–43. doi:10.1016/j.ejogrb.2012.05.002. ISSN 0301-2115.
- ^ a b "Acetylcysteine", Meyler's Side Effects of Drugs, Elsevier, pp. 23–25, 2016, retrieved 2022-05-06
- ^ a b Gupta, Rishab; Wadhwa, Roopma (2022), "Mucolytic Medications", StatPearls, Treasure Island (FL): StatPearls Publishing, PMID 32644589, retrieved 2022-05-06