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Opinions regarding the use of ANP for the treatment of acute heart failure and kidney disease are varied.[1] While this molecule has been shown to successfully restore some hemodynamic parameters following heart failure, and yield clinical improvement for kidney injury, whether it ultimately reduces mortality and its long-term effects are unknown.[2] Therefore, more studies need to be conducted to better understand the therapeutic effects of ANP.[2] Newly synthesized homologues of ANP molecule are being assessed for the treatment of acute heart failure.[3] Preliminary research on one of such molecules, ularitide, has shown that this drug is safe, well tolerated, and effective in the treatment of acute heart failure.[3]
- ^ Nigwekar, Sagar U.; Navaneethan, Sankar D.; Parikh, Chirag R.; Hix, John K. (2009-02-01). "Atrial Natriuretic Peptide for Management of Acute Kidney Injury: A Systematic Review and Meta-analysis". Clinical Journal of the American Society of Nephrology. 4 (2): 261–272. doi:10.2215/CJN.03780808. ISSN 1555-9041. PMC 2637582. PMID 19073785.
{{cite journal}}: CS1 maint: PMC format (link) - ^ a b Kobayashi, Daiki; Yamaguchi, Norihiro; Takahashi, Osamu; Deshpande, Gautam A.; Fukui, Tsuguya (2012-01). "Human Atrial Natriuretic Peptide Treatment for Acute Heart Failure: A Systematic Review of Efficacy and Mortality". Canadian Journal of Cardiology. 28 (1): 102–109. doi:10.1016/j.cjca.2011.04.011. ISSN 0828-282X.
{{cite journal}}: Check date values in:|date=(help) - ^ a b Yandrapalli, Srikanth; Jolly, George; Biswas, Medha; Rochlani, Yogita; Harikrishnan, Prakash; Aronow, Wilbert S.; Lanier, Gregg M. (2017-11-22). "Newer hormonal pharmacotherapies for heart failure". Expert Review of Endocrinology & Metabolism. 13 (1): 35–49. doi:10.1080/17446651.2018.1406799. ISSN 1744-6651.