Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 23:57, 7 November 2007 (UTC)
[edit]Proteins without matches (19)
[edit]Proteins with a High Potential Match (5)
[edit]Manual Inspection (Page not found) (16)
[edit]
Protein Status Grid - Date: 23:57, 7 November 2007 (UTC)
[edit]Vebose Log - Date: 23:57, 7 November 2007 (UTC)
[edit]- INFO: Beginning work on ABCC2... {November 7, 2007 3:33:52 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:34:37 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = ATP-binding cassette, sub-family C (CFTR/MRP), member 2
| HGNCid = 53
| Symbol = ABCC2
| AltSymbols =; ABC30; CMOAT; DJS; KIAA1010; MRP2; cMRP
| OMIM = 601107
| ECnumber =
| Homologene = 68052
| MGIid = 1352447
| GeneAtlas_image1 = PBB_GE_ABCC2_206155_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008514 |text = organic anion transmembrane transporter activity}} {{GNF_GO|id=GO:0016887 |text = ATPase activity}} {{GNF_GO|id=GO:0042626 |text = ATPase activity, coupled to transmembrane movement of substances}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016324 |text = apical plasma membrane}} {{GNF_GO|id=GO:0046581 |text = intercellular canaliculus}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1244
| Hs_Ensembl = ENSG00000023839
| Hs_RefseqProtein = NP_000383
| Hs_RefseqmRNA = NM_000392
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 10
| Hs_GenLoc_start = 101532479
| Hs_GenLoc_end = 101601939
| Hs_Uniprot = Q92887
| Mm_EntrezGene = 12780
| Mm_Ensembl = ENSMUSG00000025194
| Mm_RefseqmRNA = NM_013806
| Mm_RefseqProtein = NP_038834
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 43835715
| Mm_GenLoc_end = 43891262
| Mm_Uniprot = Q8VI46
}}
}}
'''ATP-binding cassette, sub-family C (CFTR/MRP), member 2''', also known as '''ABCC2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.<ref>{{cite web | title = Entrez Gene: ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1244| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Keppler D, König J |title=Hepatic secretion of conjugated drugs and endogenous substances. |journal=Semin. Liver Dis. |volume=20 |issue= 3 |pages= 265-72 |year= 2001 |pmid= 11076395 |doi= }}
*{{cite journal | author=Gerk PM, Vore M |title=Regulation of expression of the multidrug resistance-associated protein 2 (MRP2) and its role in drug disposition. |journal=J. Pharmacol. Exp. Ther. |volume=302 |issue= 2 |pages= 407-15 |year= 2002 |pmid= 12130697 |doi= 10.1124/jpet.102.035014 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ADAM10... {November 7, 2007 3:28:51 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein ADAM10 image.jpg {November 7, 2007 3:30:04 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:30:18 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ADAM10_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2ao7.
| PDB = {{PDB2|2ao7}}
| Name = ADAM metallopeptidase domain 10
| HGNCid = 188
| Symbol = ADAM10
| AltSymbols =; CD156c; HsT18717; MADM; kuz
| OMIM = 602192
| ECnumber =
| Homologene = 865
| MGIid = 109548
| GeneAtlas_image1 = PBB_GE_ADAM10_202603_at_tn.png
| GeneAtlas_image2 = PBB_GE_ADAM10_202604_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_ADAM10_214895_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004222 |text = metalloendopeptidase activity}} {{GNF_GO|id=GO:0005178 |text = integrin binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0019901 |text = protein kinase binding}} {{GNF_GO|id=GO:0042169 |text = SH2 domain binding}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}} {{GNF_GO|id=GO:0005798 |text = Golgi-associated vesicle}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0009986 |text = cell surface}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0001701 |text = in utero embryonic development}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006913 |text = nucleocytoplasmic transport}} {{GNF_GO|id=GO:0007162 |text = negative regulation of cell adhesion}} {{GNF_GO|id=GO:0007220 |text = Notch receptor processing}} {{GNF_GO|id=GO:0007229 |text = integrin-mediated signaling pathway}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0051089 |text = constitutive protein ectodomain proteolysis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 102
| Hs_Ensembl = ENSG00000137845
| Hs_RefseqProtein = NP_001101
| Hs_RefseqmRNA = NM_001110
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 15
| Hs_GenLoc_start = 56675802
| Hs_GenLoc_end = 56829469
| Hs_Uniprot = O14672
| Mm_EntrezGene = 11487
| Mm_Ensembl = ENSMUSG00000054693
| Mm_RefseqmRNA = NM_007399
| Mm_RefseqProtein = NP_031425
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 70478203
| Mm_GenLoc_end = 70579439
| Mm_Uniprot = Q6NZC0
}}
}}
'''ADAM metallopeptidase domain 10''', also known as '''ADAM10''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin.<ref>{{cite web | title = Entrez Gene: ADAM10 ADAM metallopeptidase domain 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=102| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Wolfsberg TG, Primakoff P, Myles DG, White JM |title=ADAM, a novel family of membrane proteins containing A Disintegrin And Metalloprotease domain: multipotential functions in cell-cell and cell-matrix interactions. |journal=J. Cell Biol. |volume=131 |issue= 2 |pages= 275-8 |year= 1995 |pmid= 7593158 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on APOA2... {November 7, 2007 3:30:18 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein APOA2 image.jpg {November 7, 2007 3:31:10 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 3:31:18 PM PST}
- CREATED: Created new protein page: APOA2 {November 7, 2007 3:31:25 PM PST}
- INFO: Beginning work on BARD1... {November 7, 2007 3:31:25 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein BARD1 image.jpg {November 7, 2007 3:32:01 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 3:32:09 PM PST}
- CREATED: Created new protein page: BARD1 {November 7, 2007 3:32:16 PM PST}
- INFO: Beginning work on BCL10... {November 7, 2007 3:48:07 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:48:33 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = B-cell CLL/lymphoma 10
| HGNCid = 989
| Symbol = BCL10
| AltSymbols =; CARMEN; CIPER; CLAP; c-E10; mE10
| OMIM = 603517
| ECnumber =
| Homologene = 2912
| MGIid = 1337994
| Function = {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0008022 |text = protein C-terminus binding}} {{GNF_GO|id=GO:0019209 |text = kinase activator activity}} {{GNF_GO|id=GO:0031625 |text = ubiquitin protein ligase binding}} {{GNF_GO|id=GO:0043130 |text = ubiquitin binding}} {{GNF_GO|id=GO:0043422 |text = protein kinase B binding}} {{GNF_GO|id=GO:0043621 |text = protein self-association}} {{GNF_GO|id=GO:0051059 |text = NF-kappaB binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005764 |text = lysosome}} {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0032449 |text = CBM complex}} {{GNF_GO|id=GO:0042101 |text = T cell receptor complex}} {{GNF_GO|id=GO:0045121 |text = lipid raft}} {{GNF_GO|id=GO:0046696 |text = lipopolysaccharide receptor complex}} {{GNF_GO|id=GO:0048471 |text = perinuclear region of cytoplasm}}
| Process = {{GNF_GO|id=GO:0002224 |text = toll-like receptor signaling pathway}} {{GNF_GO|id=GO:0002237 |text = response to molecule of bacterial origin}} {{GNF_GO|id=GO:0002250 |text = adaptive immune response}} {{GNF_GO|id=GO:0002906 |text = negative regulation of mature B cell apoptosis}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007249 |text = I-kappaB kinase/NF-kappaB cascade}} {{GNF_GO|id=GO:0008219 |text = cell death}} {{GNF_GO|id=GO:0016064 |text = immunoglobulin mediated immune response}} {{GNF_GO|id=GO:0031398 |text = positive regulation of protein ubiquitination}} {{GNF_GO|id=GO:0032765 |text = positive regulation of mast cell cytokine production}} {{GNF_GO|id=GO:0042109 |text = lymphotoxin A biosynthetic process}} {{GNF_GO|id=GO:0042221 |text = response to chemical stimulus}} {{GNF_GO|id=GO:0042226 |text = interleukin-6 biosynthetic process}} {{GNF_GO|id=GO:0042327 |text = positive regulation of phosphorylation}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}} {{GNF_GO|id=GO:0043123 |text = positive regulation of I-kappaB kinase/NF-kappaB cascade}} {{GNF_GO|id=GO:0045087 |text = innate immune response}} {{GNF_GO|id=GO:0045416 |text = positive regulation of interleukin-8 biosynthetic process}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}} {{GNF_GO|id=GO:0045893 |text = positive regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0050852 |text = T cell receptor signaling pathway}} {{GNF_GO|id=GO:0051092 |text = activation of NF-kappaB transcription factor}} {{GNF_GO|id=GO:0051260 |text = protein homooligomerization}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8915
| Hs_Ensembl =
| Hs_RefseqProtein = NP_003912
| Hs_RefseqmRNA = NM_003921
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 12042
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_009740
| Mm_RefseqProtein = NP_033870
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''B-cell CLL/lymphoma 10''', also known as '''BCL10''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.<ref>{{cite web | title = Entrez Gene: BCL10 B-cell CLL/lymphoma 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8915| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Bertoni F, Cavalli F, Cotter FE, Zucca E |title=Genetic alterations underlying the pathogenesis of MALT lymphoma. |journal=Hematol. J. |volume=3 |issue= 1 |pages= 10-3 |year= 2003 |pmid= 11960389 |doi= 10.1038/sj/thj/6200146 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CA9... {November 7, 2007 3:32:16 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:32:50 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Carbonic anhydrase IX
| HGNCid = 1383
| Symbol = CA9
| AltSymbols =; CAIX; MN
| OMIM = 603179
| ECnumber =
| Homologene = 20325
| MGIid = 2447188
| GeneAtlas_image1 = PBB_GE_CA9_205199_at_tn.png
| Function = {{GNF_GO|id=GO:0004089 |text = carbonate dehydratase activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016829 |text = lyase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0002009 |text = morphogenesis of an epithelium}} {{GNF_GO|id=GO:0006730 |text = one-carbon compound metabolic process}} {{GNF_GO|id=GO:0046903 |text = secretion}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 768
| Hs_Ensembl = ENSG00000107159
| Hs_RefseqProtein = NP_001207
| Hs_RefseqmRNA = NM_001216
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 35663853
| Hs_GenLoc_end = 35671156
| Hs_Uniprot = Q16790
| Mm_EntrezGene = 230099
| Mm_Ensembl = ENSMUSG00000028463
| Mm_RefseqmRNA = NM_139305
| Mm_RefseqProtein = NP_647466
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 43528107
| Mm_GenLoc_end = 43534829
| Mm_Uniprot = Q3TLN7
}}
}}
'''Carbonic anhydrase IX''', also known as '''CA9''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and the only tumor-associated carbonic anhydrase isoenzyme known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12.<ref>{{cite web | title = Entrez Gene: CA9 carbonic anhydrase IX| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=768| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Nishimori I, Onishi S |title=Carbonic anhydrase isozymes in the human pancreas. |journal=Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver |volume=33 |issue= 1 |pages= 68-74 |year= 2001 |pmid= 11303978 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CCKBR... {November 7, 2007 3:32:50 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CCKBR image.jpg {November 7, 2007 3:33:22 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 3:33:44 PM PST}
- CREATED: Created new protein page: CCKBR {November 7, 2007 3:33:52 PM PST}
- INFO: Beginning work on DCTN1... {November 7, 2007 3:34:37 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein DCTN1 image.jpg {November 7, 2007 3:35:24 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 3:35:37 PM PST}
- CREATED: Created new protein page: DCTN1 {November 7, 2007 3:35:44 PM PST}
- INFO: Beginning work on GNRHR... {November 7, 2007 3:35:44 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:36:58 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Gonadotropin-releasing hormone receptor
| HGNCid = 4421
| Symbol = GNRHR
| AltSymbols =; GNRHR1; GRHR; LHRHR; LRHR
| OMIM = 138850
| ECnumber =
| Homologene = 350
| MGIid = 95790
| GeneAtlas_image1 = PBB_GE_GNRHR_216341_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_GNRHR_211522_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_GNRHR_211523_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004968 |text = gonadotropin-releasing hormone receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2798
| Hs_Ensembl = ENSG00000109163
| Hs_RefseqProtein = NP_000397
| Hs_RefseqmRNA = NM_000406
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 68285701
| Hs_GenLoc_end = 68304399
| Hs_Uniprot = P30968
| Mm_EntrezGene = 14715
| Mm_Ensembl = ENSMUSG00000029255
| Mm_RefseqmRNA = NM_010323
| Mm_RefseqProtein = NP_034453
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 87256547
| Mm_GenLoc_end = 87272431
| Mm_Uniprot = Q01776
}}
}}
'''Gonadotropin-releasing hormone receptor''', also known as '''GNRHR''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene.<ref>{{cite web | title = Entrez Gene: GNRHR gonadotropin-releasing hormone receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2798| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Michel U, Farnworth P, Findlay JK |title=Follistatins: more than follicle-stimulating hormone suppressing proteins. |journal=Mol. Cell. Endocrinol. |volume=91 |issue= 1-2 |pages= 1-11 |year= 1993 |pmid= 8472841 |doi= }}
*{{cite journal | author=Flanagan CA, Millar RP, Illing N |title=Advances in understanding gonadotrophin-releasing hormone receptor structure and ligand interactions. |journal=Rev. Reprod. |volume=2 |issue= 2 |pages= 113-20 |year= 1998 |pmid= 9414473 |doi= }}
*{{cite journal | author=Limonta P, Moretti RM, Marelli MM, Motta M |title=The biology of gonadotropin hormone-releasing hormone: role in the control of tumor growth and progression in humans. |journal=Frontiers in neuroendocrinology |volume=24 |issue= 4 |pages= 279-95 |year= 2004 |pmid= 14726258 |doi= }}
*{{cite journal | author=Bédécarrats GY, Kaiser UB |title=Mutations in the human gonadotropin-releasing hormone receptor: insights into receptor biology and function. |journal=Semin. Reprod. Med. |volume=25 |issue= 5 |pages= 368-78 |year= 2007 |pmid= 17710733 |doi= 10.1055/s-2007-984743 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on LAT... {November 7, 2007 3:49:15 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:49:29 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Linker for activation of T cells
| HGNCid = 18874
| Symbol = LAT
| AltSymbols =; LAT1; pp36
| OMIM = 602354
| ECnumber =
| Homologene = 7811
| MGIid = 1342293
| Function = {{GNF_GO|id=GO:0005070 |text = SH3/SH2 adaptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0001772 |text = immunological synapse}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0045121 |text = lipid raft}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007229 |text = integrin-mediated signaling pathway}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0007265 |text = Ras protein signal transduction}} {{GNF_GO|id=GO:0019722 |text = calcium-mediated signaling}} {{GNF_GO|id=GO:0043303 |text = mast cell degranulation}} {{GNF_GO|id=GO:0050863 |text = regulation of T cell activation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 27040
| Hs_Ensembl =
| Hs_RefseqProtein = NP_001014987
| Hs_RefseqmRNA = NM_001014987
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 16797
| Mm_Ensembl = ENSMUSG00000030742
| Mm_RefseqmRNA = NM_010689
| Mm_RefseqProtein = NP_034819
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 126154975
| Mm_GenLoc_end = 126160691
| Mm_Uniprot = Q546H1
}}
}}
'''Linker for activation of T cells''', also known as '''LAT''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms.<ref>{{cite web | title = Entrez Gene: LAT linker for activation of T cells| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27040| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Wange RL |title=LAT, the linker for activation of T cells: a bridge between T cell-specific and general signaling pathways. |journal=Sci. STKE |volume=2000 |issue= 63 |pages= RE1 |year= 2002 |pmid= 11752630 |doi= 10.1126/stke.2000.63.re1 }}
*{{cite journal | author=Sommers CL, Samelson LE, Love PE |title=LAT: a T lymphocyte adapter protein that couples the antigen receptor to downstream signaling pathways. |journal=Bioessays |volume=26 |issue= 1 |pages= 61-7 |year= 2004 |pmid= 14696041 |doi= 10.1002/bies.10384 }}
*{{cite journal | author=Rivera J |title=NTAL/LAB and LAT: a balancing act in mast-cell activation and function. |journal=Trends Immunol. |volume=26 |issue= 3 |pages= 119-22 |year= 2005 |pmid= 15745852 |doi= 10.1016/j.it.2005.01.001 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MEF2A... {November 7, 2007 3:36:58 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 3:38:14 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:38:28 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_MEF2A_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1c7u.
| PDB = {{PDB2|1c7u}}, {{PDB2|1egw}}
| Name = MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A)
| HGNCid = 6993
| Symbol = MEF2A
| AltSymbols =; ADCAD1; RSRFC4; RSRFC9
| OMIM = 600660
| ECnumber =
| Homologene = 4080
| MGIid = 99532
| GeneAtlas_image1 = PBB_GE_MEF2A_214684_at_tn.png
| GeneAtlas_image2 = PBB_GE_MEF2A_208328_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_MEF2A_212535_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0007517 |text = muscle development}} {{GNF_GO|id=GO:0045941 |text = positive regulation of transcription}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4205
| Hs_Ensembl = ENSG00000068305
| Hs_RefseqProtein = NP_005578
| Hs_RefseqmRNA = NM_005587
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 15
| Hs_GenLoc_start = 97923712
| Hs_GenLoc_end = 98074131
| Hs_Uniprot = Q02078
| Mm_EntrezGene = 17258
| Mm_Ensembl = ENSMUSG00000030557
| Mm_RefseqmRNA = XM_975927
| Mm_RefseqProtein = XP_981021
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 67113818
| Mm_GenLoc_end = 67174528
| Mm_Uniprot = Q6P8Q3
}}
}}
'''MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A)''', also known as '''MEF2A''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The process of differentiation from mesodermal precursor cells to myoblasts has led to the discovery of a variety of tissue-specific factors that regulate muscle gene expression. The myogenic basic helix-loop-helix proteins, including myoD (MIM 159970), myogenin (MIM 159980), MYF5 (MIM 159990), and MRF4 (MIM 159991) are 1 class of identified factors. A second family of DNA binding regulatory proteins is the myocyte-specific enhancer factor-2 (MEF2) family. Each of these proteins binds to the MEF2 target DNA sequence present in the regulatory regions of many, if not all, muscle-specific genes. The MEF2 genes are members of the MADS gene family (named for the yeast mating type-specific transcription factor MCM1, the plant homeotic genes 'agamous' and 'deficiens' and the human serum response factor SRF (MIM 600589)), a family that also includes several homeotic genes and other transcription factors, all of which share a conserved DNA-binding domain.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: MEF2A MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4205| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Wang Q |title=Advances in the genetic basis of coronary artery disease. |journal=Current atherosclerosis reports |volume=7 |issue= 3 |pages= 235-41 |year= 2005 |pmid= 15811259 |doi= }}
*{{cite journal | author=Wang Q |title=Molecular genetics of coronary artery disease. |journal=Curr. Opin. Cardiol. |volume=20 |issue= 3 |pages= 182-8 |year= 2005 |pmid= 15861005 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MUTYH... {November 7, 2007 3:38:48 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein MUTYH image.jpg {November 7, 2007 3:39:25 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:39:36 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_MUTYH_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1x51.
| PDB = {{PDB2|1x51}}
| Name = MutY homolog (E. coli)
| HGNCid = 7527
| Symbol = MUTYH
| AltSymbols =; MGC4416; MYH
| OMIM = 604933
| ECnumber =
| Homologene = 8156
| MGIid = 1917853
| GeneAtlas_image1 = PBB_GE_MUTYH_207727_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0004519 |text = endonuclease activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0016798 |text = hydrolase activity, acting on glycosyl bonds}} {{GNF_GO|id=GO:0019104 |text = DNA N-glycosylase activity}} {{GNF_GO|id=GO:0032405 |text = MutLalpha complex binding}} {{GNF_GO|id=GO:0032406 |text = MutLbeta complex binding}} {{GNF_GO|id=GO:0032407 |text = MutSalpha complex binding}} {{GNF_GO|id=GO:0032408 |text = MutSbeta complex binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0051539 |text = 4 iron, 4 sulfur cluster binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006284 |text = base-excision repair}} {{GNF_GO|id=GO:0006298 |text = mismatch repair}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0008152 |text = metabolic process}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4595
| Hs_Ensembl = ENSG00000132781
| Hs_RefseqProtein = NP_001041636
| Hs_RefseqmRNA = NM_001048171
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 45567501
| Hs_GenLoc_end = 45578729
| Hs_Uniprot = Q9UIF7
| Mm_EntrezGene = 70603
| Mm_Ensembl = ENSMUSG00000028687
| Mm_RefseqmRNA = NM_133250
| Mm_RefseqProtein = NP_573513
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 116305655
| Mm_GenLoc_end = 116317370
| Mm_Uniprot = Q762C9
}}
}}
'''MutY homolog (E. coli)''', also known as '''MUTYH''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: MUTYH mutY homolog (E. coli)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4595| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Lindahl T, Wood RD |title=Quality control by DNA repair. |journal=Science |volume=286 |issue= 5446 |pages= 1897-905 |year= 1999 |pmid= 10583946 |doi= }}
*{{cite journal | author=Nakabeppu Y |title=Regulation of intracellular localization of human MTH1, OGG1, and MYH proteins for repair of oxidative DNA damage. |journal=Prog. Nucleic Acid Res. Mol. Biol. |volume=68 |issue= |pages= 75-94 |year= 2001 |pmid= 11554314 |doi= }}
*{{cite journal | author=Lipton L, Tomlinson I |title=The multiple colorectal adenoma phenotype and MYH, a base excision repair gene. |journal=Clin. Gastroenterol. Hepatol. |volume=2 |issue= 8 |pages= 633-8 |year= 2004 |pmid= 15290654 |doi= }}
*{{cite journal | author=Sampson JR, Jones S, Dolwani S, Cheadle JP |title=MutYH (MYH) and colorectal cancer. |journal=Biochem. Soc. Trans. |volume=33 |issue= Pt 4 |pages= 679-83 |year= 2005 |pmid= 16042573 |doi= 10.1042/BST0330679 }}
*{{cite journal | author=Castellví-Bel S, Balaguer F, Castells A |title=[MYH and colorectal cancer. A significant advance?] |journal=Gastroenterología y hepatología |volume=29 |issue= 7 |pages= 409-13 |year= 2006 |pmid= 16938257 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on NCF1C... {November 7, 2007 3:49:29 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 3:49:41 PM PST}
- CREATED: Created new protein page: NCF1C {November 7, 2007 3:49:48 PM PST}
- INFO: Beginning work on ND2... {November 7, 2007 3:38:28 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 3:38:41 PM PST}
- CREATED: Created new protein page: ND2 {November 7, 2007 3:38:48 PM PST}
- INFO: Beginning work on PLD2... {November 7, 2007 3:39:37 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 3:40:06 PM PST}
- CREATED: Created new protein page: PLD2 {November 7, 2007 3:40:13 PM PST}
- INFO: Beginning work on PRKG1... {November 7, 2007 3:40:13 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:41:34 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Protein kinase, cGMP-dependent, type I
| HGNCid = 9414
| Symbol = PRKG1
| AltSymbols =; CGKI; FLJ36117; MGC71944; PGK; PRKG1B; PRKGR1B; cGKI-BETA; cGKI-alpha
| OMIM = 176894
| ECnumber =
| Homologene = 55964
| MGIid = 108174
| GeneAtlas_image1 = PBB_GE_PRKG1_211380_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PRKG1_207119_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004692 |text = cGMP-dependent protein kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008603 |text = cAMP-dependent protein kinase regulator activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0030553 |text = cGMP binding}}
| Component = {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}} {{GNF_GO|id=GO:0005952 |text = cAMP-dependent protein kinase complex}}
| Process = {{GNF_GO|id=GO:0001764 |text = neuron migration}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006940 |text = regulation of smooth muscle contraction}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0016358 |text = dendrite development}} {{GNF_GO|id=GO:0030036 |text = actin cytoskeleton organization and biogenesis}} {{GNF_GO|id=GO:0030900 |text = forebrain development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5592
| Hs_Ensembl = ENSG00000185532
| Hs_RefseqProtein = NP_006249
| Hs_RefseqmRNA = NM_006258
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 10
| Hs_GenLoc_start = 52421124
| Hs_GenLoc_end = 53728116
| Hs_Uniprot = Q13976
| Mm_EntrezGene = 19091
| Mm_Ensembl = ENSMUSG00000052920
| Mm_RefseqmRNA = XM_993724
| Mm_RefseqProtein = XP_998818
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 30635235
| Mm_GenLoc_end = 31830819
| Mm_Uniprot = Q14DK6
}}
}}
'''Protein kinase, cGMP-dependent, type I''', also known as '''PRKG1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PTTG1... {November 7, 2007 3:48:33 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:49:15 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Pituitary tumor-transforming 1
| HGNCid = 9690
| Symbol = PTTG1
| AltSymbols =; EAP1; HPTTG; MGC126883; MGC138276; PTTG; SECURIN; TUTR1
| OMIM = 604147
| ECnumber =
| Homologene = 3110
| MGIid = 1353578
| GeneAtlas_image1 = PBB_GE_PTTG1_203554_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0004869 |text = cysteine protease inhibitor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006259 |text = DNA metabolic process}} {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007059 |text = chromosome segregation}} {{GNF_GO|id=GO:0007067 |text = mitosis}} {{GNF_GO|id=GO:0007283 |text = spermatogenesis}} {{GNF_GO|id=GO:0051276 |text = chromosome organization and biogenesis}} {{GNF_GO|id=GO:0051301 |text = cell division}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 9232
| Hs_Ensembl = ENSG00000164611
| Hs_RefseqProtein = NP_004210
| Hs_RefseqmRNA = NM_004219
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 159781418
| Hs_GenLoc_end = 159788323
| Hs_Uniprot = O95997
| Mm_EntrezGene = 30939
| Mm_Ensembl = ENSMUSG00000020415
| Mm_RefseqmRNA = NM_013917
| Mm_RefseqProtein = NP_038945
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 43263685
| Mm_GenLoc_end = 43269674
| Mm_Uniprot = Q3Y5K4
}}
}}
'''Pituitary tumor-transforming 1''', also known as '''PTTG1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.<ref>{{cite web | title = Entrez Gene: PTTG1 pituitary tumor-transforming 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9232| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Yu R, Melmed S |title=Pituitary tumor transforming gene: an update. |journal=Frontiers of hormone research |volume=32 |issue= |pages= 175-85 |year= 2004 |pmid= 15281346 |doi= }}
*{{cite journal | author=Tfelt-Hansen J, Kanuparthi D, Chattopadhyay N |title=The emerging role of pituitary tumor transforming gene in tumorigenesis. |journal=Clinical medicine & research |volume=4 |issue= 2 |pages= 130-7 |year= 2006 |pmid= 16809406 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RGS4... {November 7, 2007 3:41:34 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein RGS4 image.jpg {November 7, 2007 3:42:48 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:43:04 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_RGS4_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1agr.
| PDB = {{PDB2|1agr}}, {{PDB2|1ezt}}, {{PDB2|1ezy}}
| Name = Regulator of G-protein signalling 4
| HGNCid = 10000
| Symbol = RGS4
| AltSymbols =; MGC2124; MGC60244; RGP4; SCZD9
| OMIM = 602516
| ECnumber =
| Homologene = 4100
| MGIid = 108409
| GeneAtlas_image1 = PBB_GE_RGS4_204337_at_tn.png
| GeneAtlas_image2 = PBB_GE_RGS4_204338_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_RGS4_204339_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005096 |text = GTPase activator activity}} {{GNF_GO|id=GO:0005516 |text = calmodulin binding}}
| Component =
| Process = {{GNF_GO|id=GO:0000188 |text = inactivation of MAPK activity}} {{GNF_GO|id=GO:0008277 |text = regulation of G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0009968 |text = negative regulation of signal transduction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5999
| Hs_Ensembl = ENSG00000117152
| Hs_RefseqProtein = NP_005604
| Hs_RefseqmRNA = NM_005613
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 161305673
| Hs_GenLoc_end = 161313006
| Hs_Uniprot = P49798
| Mm_EntrezGene = 19736
| Mm_Ensembl = ENSMUSG00000038530
| Mm_RefseqmRNA = NM_009062
| Mm_RefseqProtein = NP_033088
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 171578985
| Mm_GenLoc_end = 171584317
| Mm_Uniprot = Q5D078
}}
}}
'''Regulator of G-protein signalling 4''', also known as '''RGS4''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm.<ref>{{cite web | title = Entrez Gene: RGS4 regulator of G-protein signalling 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5999| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Levitt P, Ebert P, Mirnics K, ''et al.'' |title=Making the case for a candidate vulnerability gene in schizophrenia: Convergent evidence for regulator of G-protein signaling 4 (RGS4). |journal=Biol. Psychiatry |volume=60 |issue= 6 |pages= 534-7 |year= 2006 |pmid= 16860780 |doi= 10.1016/j.biopsych.2006.04.028 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SLC2A4... {November 7, 2007 3:43:04 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:43:34 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Solute carrier family 2 (facilitated glucose transporter), member 4
| HGNCid = 11009
| Symbol = SLC2A4
| AltSymbols =; GLUT4
| OMIM = 138190
| ECnumber =
| Homologene = 74381
| MGIid = 95758
| GeneAtlas_image1 = PBB_GE_SLC2A4_206603_at_tn.png
| Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0005351 |text = sugar:hydrogen ion symporter activity}} {{GNF_GO|id=GO:0005355 |text = glucose transmembrane transporter activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0009897 |text = external side of plasma membrane}} {{GNF_GO|id=GO:0012506 |text = vesicle membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0048471 |text = perinuclear region of cytoplasm}}
| Process = {{GNF_GO|id=GO:0005975 |text = carbohydrate metabolic process}} {{GNF_GO|id=GO:0008643 |text = carbohydrate transport}} {{GNF_GO|id=GO:0015758 |text = glucose transport}} {{GNF_GO|id=GO:0042593 |text = glucose homeostasis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6517
| Hs_Ensembl = ENSG00000181856
| Hs_RefseqProtein = NP_001033
| Hs_RefseqmRNA = NM_001042
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 7125777
| Hs_GenLoc_end = 7132300
| Hs_Uniprot = P14672
| Mm_EntrezGene = 20528
| Mm_Ensembl = ENSMUSG00000018566
| Mm_RefseqmRNA = NM_009204
| Mm_RefseqProtein = NP_033230
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 69758738
| Mm_GenLoc_end = 69764344
| Mm_Uniprot = Q5NCW7
}}
}}
'''Solute carrier family 2 (facilitated glucose transporter), member 4''', also known as '''SLC2A4''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM).<ref>{{cite web | title = Entrez Gene: SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6517| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Foster LJ, Klip A |title=Mechanism and regulation of GLUT-4 vesicle fusion in muscle and fat cells. |journal=Am. J. Physiol., Cell Physiol. |volume=279 |issue= 4 |pages= C877-90 |year= 2000 |pmid= 11003568 |doi= }}
*{{cite journal | author=Bryant NJ, Govers R, James DE |title=Regulated transport of the glucose transporter GLUT4. |journal=Nat. Rev. Mol. Cell Biol. |volume=3 |issue= 4 |pages= 267-77 |year= 2002 |pmid= 11994746 |doi= 10.1038/nrm782 }}
*{{cite journal | author=Baumann MU, Deborde S, Illsley NP |title=Placental glucose transfer and fetal growth. |journal=Endocrine |volume=19 |issue= 1 |pages= 13-22 |year= 2003 |pmid= 12583599 |doi= }}
*{{cite journal | author=Olson AL, Knight JB |title=Regulation of GLUT4 expression in vivo and in vitro. |journal=Front. Biosci. |volume=8 |issue= |pages= s401-9 |year= 2004 |pmid= 12700047 |doi= }}
*{{cite journal | author=McCarthy AM, Elmendorf JS |title=GLUT4's itinerary in health & disease. |journal=Indian J. Med. Res. |volume=125 |issue= 3 |pages= 373-88 |year= 2007 |pmid= 17496362 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SOX9... {November 7, 2007 3:43:34 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:44:26 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal)
| HGNCid = 11204
| Symbol = SOX9
| AltSymbols =; CMPD1; CMD1; SRA1
| OMIM = 608160
| ECnumber =
| Homologene = 294
| MGIid = 98371
| GeneAtlas_image1 = PBB_GE_SOX9_202936_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SOX9_202935_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003704 |text = specific RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016563 |text = transcription activator activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0001501 |text = skeletal development}} {{GNF_GO|id=GO:0001502 |text = cartilage condensation}} {{GNF_GO|id=GO:0001708 |text = cell fate specification}} {{GNF_GO|id=GO:0001837 |text = epithelial to mesenchymal transition}} {{GNF_GO|id=GO:0001942 |text = hair follicle development}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0007507 |text = heart development}} {{GNF_GO|id=GO:0008584 |text = male gonad development}} {{GNF_GO|id=GO:0014032 |text = neural crest cell development}} {{GNF_GO|id=GO:0019100 |text = male germ-line sex determination}} {{GNF_GO|id=GO:0042127 |text = regulation of cell proliferation}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}} {{GNF_GO|id=GO:0045892 |text = negative regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6662
| Hs_Ensembl = ENSG00000125398
| Hs_RefseqProtein = NP_000337
| Hs_RefseqmRNA = NM_000346
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 67628756
| Hs_GenLoc_end = 67634147
| Hs_Uniprot = P48436
| Mm_EntrezGene = 20682
| Mm_Ensembl = ENSMUSG00000000567
| Mm_RefseqmRNA = NM_011448
| Mm_RefseqProtein = NP_035578
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 112598314
| Mm_GenLoc_end = 112603839
| Mm_Uniprot = Q571J2
}}
}}
'''SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal)''', also known as '''SOX9''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins. It acts during chondrocyte differentiation and, with steroidogenic factor 1, regulates transcription of the anti-Muellerian hormone (AMH) gene. Deficiencies lead to the skeletal malformation syndrome campomelic dysplasia, frequently with sex reversal.<ref>{{cite web | title = Entrez Gene: SOX9 SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6662| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Ninomiya S, Narahara K, Tsuji K, ''et al.'' |title=Acampomelic campomelic syndrome and sex reversal associated with de novo t(12;17) translocation. |journal=Am. J. Med. Genet. |volume=56 |issue= 1 |pages= 31-4 |year= 1995 |pmid= 7747782 |doi= 10.1002/ajmg.1320560109 }}
*{{cite journal | author=Lefebvre V, de Crombrugghe B |title=Toward understanding SOX9 function in chondrocyte differentiation. |journal=Matrix Biol. |volume=16 |issue= 9 |pages= 529-40 |year= 1998 |pmid= 9569122 |doi= }}
*{{cite journal | author=Harley VR |title=The molecular action of testis-determining factors SRY and SOX9. |journal=Novartis Found. Symp. |volume=244 |issue= |pages= 57-66; discussion 66-7, 79-85, 253-7 |year= 2002 |pmid= 11990798 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TITF1... {November 7, 2007 3:44:26 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein TITF1 image.jpg {November 7, 2007 3:45:17 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:45:43 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TITF1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ftt.
| PDB = {{PDB2|1ftt}}
| Name = Thyroid transcription factor 1
| HGNCid = 11825
| Symbol = TITF1
| AltSymbols =; BCH; BHC; NK-2; NKX2.1; NKX2A; TEBP; TTF-1; TTF1
| OMIM = 600635
| ECnumber =
| Homologene = 2488
| MGIid = 108067
| GeneAtlas_image1 = PBB_GE_TITF1_210673_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_TITF1_211024_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016563 |text = transcription activator activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005654 |text = nucleoplasm}} {{GNF_GO|id=GO:0005667 |text = transcription factor complex}}
| Process = {{GNF_GO|id=GO:0001764 |text = neuron migration}} {{GNF_GO|id=GO:0007389 |text = pattern specification process}} {{GNF_GO|id=GO:0007420 |text = brain development}} {{GNF_GO|id=GO:0007492 |text = endoderm development}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}} {{GNF_GO|id=GO:0030324 |text = lung development}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7080
| Hs_Ensembl = ENSG00000136352
| Hs_RefseqProtein = NP_001073136
| Hs_RefseqmRNA = NM_001079668
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 14
| Hs_GenLoc_start = 36055357
| Hs_GenLoc_end = 36059167
| Hs_Uniprot = P43699
| Mm_EntrezGene = 21869
| Mm_Ensembl = ENSMUSG00000001496
| Mm_RefseqmRNA = NM_009385
| Mm_RefseqProtein = NP_033411
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 12
| Mm_GenLoc_start = 57449968
| Mm_GenLoc_end = 57454920
| Mm_Uniprot = Q6PFE0
}}
}}
'''Thyroid transcription factor 1''', also known as '''TITF1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Lau SK, Luthringer DJ, Eisen RN |title=Thyroid transcription factor-1: a review. |journal=Appl. Immunohistochem. Mol. Morphol. |volume=10 |issue= 2 |pages= 97-102 |year= 2002 |pmid= 12051643 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on UCP3... {November 7, 2007 3:45:43 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 3:46:39 PM PST}
- CREATED: Created new protein page: UCP3 {November 7, 2007 3:46:46 PM PST}
- INFO: Beginning work on USF1... {November 7, 2007 3:46:46 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein USF1 image.jpg {November 7, 2007 3:47:03 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:47:24 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_USF1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1an4.
| PDB = {{PDB2|1an4}}
| Name = Upstream transcription factor 1
| HGNCid = 12593
| Symbol = USF1
| AltSymbols =; FCHL; FCHL1; HYPLIP1; MLTF; MLTFI; UEF
| OMIM = 191523
| ECnumber =
| Homologene = 31426
| MGIid = 99542
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003704 |text = specific RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0030528 |text = transcription regulator activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0045449 |text = regulation of transcription}} {{GNF_GO|id=GO:0045893 |text = positive regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7391
| Hs_Ensembl = ENSG00000158773
| Hs_RefseqProtein = NP_009053
| Hs_RefseqmRNA = NM_007122
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 159275665
| Hs_GenLoc_end = 159282391
| Hs_Uniprot = P22415
| Mm_EntrezGene = 22278
| Mm_Ensembl = ENSMUSG00000026641
| Mm_RefseqmRNA = NM_009480
| Mm_RefseqProtein = NP_033506
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 173248059
| Mm_GenLoc_end = 173254796
| Mm_Uniprot = O09135
}}
}}
'''Upstream transcription factor 1''', also known as '''USF1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Two transcript variants encoding distinct isoforms have been identified for this gene.<ref>{{cite web | title = Entrez Gene: USF1 upstream transcription factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7391| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Corre S, Galibert MD |title=[USF as a key regulatory element of gene expression] |journal=Med Sci (Paris) |volume=22 |issue= 1 |pages= 62-7 |year= 2006 |pmid= 16386222 |doi= }}
*{{cite journal | author=Lee JC, Lusis AJ, Pajukanta P |title=Familial combined hyperlipidemia: upstream transcription factor 1 and beyond. |journal=Curr. Opin. Lipidol. |volume=17 |issue= 2 |pages= 101-9 |year= 2007 |pmid= 16531745 |doi= 10.1097/01.mol.0000217890.54875.13 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on XPC... {November 7, 2007 3:47:24 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:48:07 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Xeroderma pigmentosum, complementation group C
| HGNCid = 12816
| Symbol = XPC
| AltSymbols =; XP3; XPCC
| OMIM = 278720
| ECnumber =
| Homologene = 3401
| MGIid = 103557
| GeneAtlas_image1 = PBB_GE_XPC_209375_at_tn.png
| Function = {{GNF_GO|id=GO:0003684 |text = damaged DNA binding}} {{GNF_GO|id=GO:0003697 |text = single-stranded DNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006289 |text = nucleotide-excision repair}} {{GNF_GO|id=GO:0031573 |text = intra-S DNA damage checkpoint}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7508
| Hs_Ensembl = ENSG00000154767
| Hs_RefseqProtein = NP_004619
| Hs_RefseqmRNA = NM_004628
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 14161651
| Hs_GenLoc_end = 14195143
| Hs_Uniprot = Q01831
| Mm_EntrezGene = 22591
| Mm_Ensembl = ENSMUSG00000030094
| Mm_RefseqmRNA = NM_009531
| Mm_RefseqProtein = NP_033557
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 91454814
| Mm_GenLoc_end = 91481329
| Mm_Uniprot = Q7TSZ1
}}
}}
'''Xeroderma pigmentosum, complementation group C''', also known as '''XPC''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Cleaver JE, Thompson LH, Richardson AS, States JC |title=A summary of mutations in the UV-sensitive disorders: xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy. |journal=Hum. Mutat. |volume=14 |issue= 1 |pages= 9-22 |year= 1999 |pmid= 10447254 |doi= 10.1002/(SICI)1098-1004(1999)14:1<9::AID-HUMU2>3.0.CO;2-6 }}
*{{cite journal | author=El-Deiry WS |title=Transactivation of repair genes by BRCA1. |journal=Cancer Biol. Ther. |volume=1 |issue= 5 |pages= 490-1 |year= 2003 |pmid= 12496474 |doi= }}
*{{cite journal | author=Sugasawa K |title=UV-induced ubiquitylation of XPC complex, the UV-DDB-ubiquitin ligase complex, and DNA repair. |journal=J. Mol. Histol. |volume=37 |issue= 5-7 |pages= 189-202 |year= 2007 |pmid= 16858626 |doi= 10.1007/s10735-006-9044-7 }}
}}
{{refend}}
{{protein-stub}}
end log.
