User:Noroz6420/STH (gene)
Saitohin is a protein that in humans is encoded by the STH gene.[1][2][3] This intronless gene encodes for 128 amino acids in an open reading frame. It is located in the human tau gene, in the intron between exons 9 and 10. Also, a single polymorphism of a nucleotide is seen through a change of glutamine residue 7(Q7R) to arginine.[4] It is found to be susceptible to multiple degenerative diseases, however, the exact function of the gene is still unknown.[5]
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[edit]References
[edit]- ^ Conrad C, Vianna C, Freeman M, Davies P (May 2002). "A polymorphic gene nested within an intron of the tau gene: implications for Alzheimer's disease". Proc Natl Acad Sci U S A. 99 (11): 7751–6. doi:10.1073/pnas.112194599. PMC 124341. PMID 12032355.
- ^ Gao L, Tse SW, Conrad C, Andreadis A (Nov 2005). "Saitohin, which is nested in the tau locus and confers allele-specific susceptibility to several neurodegenerative diseases, interacts with peroxiredoxin 6". J Biol Chem. 280 (47): 39268–72. doi:10.1074/jbc.M506116200. PMID 16186110.
- ^ "Entrez Gene: STH saitohin".
- ^ Conrad C, Vianna C, Freeman M, Davies P (May 2002). "A polymorphic gene nested within an intron of the tau gene: implications for Alzheimer's disease". Proc Natl Acad Sci U S A. 99 (11): 7751–6. doi:10.1073/pnas.112194599. PMC 124341. PMID 12032355.
- ^ Gao L, Tse SW, Conrad C, Andreadis A (Nov 2005). "Saitohin, which is nested in the tau locus and confers allele-specific susceptibility to several neurodegenerative diseases, interacts with peroxiredoxin 6". J Biol Chem. 280 (47): 39268–72. doi:10.1074/jbc.M506116200. PMID 16186110.