Karan Mehra as Naitik "Munna" Singhania: Gayatri and Rajshekar's son; Rashmi's elder brother; Antara's widower; Sandhya's husband; Naksh and Naira's father; Naitik Jr., Krish, Kairav and Kaira's grandfather; Ved, Vansh and Kanak's step father. (2009–2018)
Harsh / Bani / Rohan Mehra / as Naksh "Chikku" "Lalla" "Duggu" "Nic" Singhania: Antara and Naitik's son; Naira's elder brother; Riya, Sanjana and Nisha's ex boyfriend; Tara and Vedika's ex-fiancé; Keerti's husband; Sandhya's step son; Ved, Vansh and Kanak's step brother. (2012-2021)
Rishi Dev as Naitik Jr. Singhania: Naksh and Keerti's son; Krish, Kairav and Kaira's cousin. (2020)
Mishka Jain / Ashnoor Kaur / Shivangi Joshi as Sumedha "Naira" "Tina" Singhania Goenka: Antara and Naitik's daughter; Naksh's younger sister; Tarun and Chandu's girlfriend; Aditya's ex fiancée; Kartik's widow; Krish, Kairav and Kaira's mother; Raghav's second wife; Sandhya's step daughter; Ved, Vansh and Kanak's step sister. (2015–2021)
Krishiv Mutha / Shaurya Shah / Tanmay Shah / Aarambh Trehan / Mayank Arora / Abeer Singh Godhwani as Kairav Goenka: Naira and Kartik's son; Krish's younger brother; Kaira's elder brother; Anisha's ex-fiancé; Muskaan's husband; Raghav's step son. (2019-present)
Kairav Waghela / Pranali Rathod as Kaira "Sirat" Goenka Sharma (née Birla): Famous Boxer, Singer, former music therapist at Birla Hospital and Medical Institute; Naira and Kartik's daughter; Krish and Kairav's younger sister; Ranveer's widow; Aarohi's mother; Abhimanyu's ex-wife amd fiancée; Abhinav's widow; Abhir's mother; Raghav's step daughter. (2020–present)
Siya Makwana / Karishma Sawant as Dr. Aarohi "Aaru" Goenka Birla: Doctor at Birla Hospital and Medical Institute; Kaira and Ranveer's daughter; Abhir's half-sister; Abhimanyu's ex-fiancée; Neil's widow; Ruhi's mother. (2021–present)
Paras Priyadarshan as Neil Birla: Avni and Harshvardhan's son; Manjari's adopted son; Abhimanyu's half-brother; Aarohi's husband; Ruhi's father. (2021–2022)
Hera Mishra as Ruhi "Rooh" Birla: Aarohi and Neil's daughter; Abhimanyu's adopted daughter. (2023–present)
Het Makwana / Harshad Chopda as Dr. Abhimanyu "Abhi" Birla: Surgeon at Birla Hospital and Medical Institute; Manjari and Harshvardhan's son; Neil's half-brother; Aarohi's ex-fiancé; Kaira's ex-husband and fiancé; Ruhi's adoptive father. (2021–present)
Jay Soni as Abhinav Sharma: Muskan's sworn brother; Kaira's husband; Abhir's father. (2022–2023)
Shreyansh Kaurav as Abhir Sharma: Kaira and Abhinav's son. (2023–present)
Yamini Makwana / Harbandna Kaur / Kaveri Priyam as Sunaina "Kanak" "Kuhu" "Naina" Singhania Goenka: IPS Sandhya and IPS Satyadev's daughter; Ved and Vansh's younger sister; Naitik's step daughter; Naksh and Naira's step sister; Kunal's widow; Vansh, Vatsal and Amish's mother; Uma's ex wife. (2016-2019)
Maaz Champ / Siddharth Dubey / Sharan Anandani as Vansh Goenka: Kanak and Vivan's son; Shubham's step-son; Vatsal and Amish's half-brother. (2019–2022)
Devaj Bhanushali as Baby Vatsal Goenka: Kanak and Samarth's first son; Vansh's half-brother; Amish's elder brother. (2020)
Unknown as Amish Goenka: Kanak and Samarth's second son; Vansh half brother; Vatsal's younger brother. (2020)
