User:Mr. Ibrahem/Teniposide

Mr. Ibrahem/Teniposide
Clinical data
Trade names	Vumon
Other names	VM-26
AHFS/Drugs.com	Monograph
MedlinePlus	a692045
Pregnancy; category	AU: D; ;
Routes of; administration	Intravenous
Drug class	Podophyllotoxin derivative
Legal status
Legal status	US: ℞-only;
Pharmacokinetic data
Bioavailability	N/A
Protein binding	>99%
Metabolism	Liver (CYP2C19-mediated)
Elimination half-life	5 hours
Excretion	Kidney and fecal
Identifiers
	IUPAC name (5R,5aR,8aR,9S)-5,8,8a,9-Tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-({4,6-O-[(R)-2-thienylmethylene]-β-D-glucopyranosyl}oxy)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one;
Chemical and physical data
Formula	C32H32O13S
Molar mass	656.66 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES COc1cc(cc(c1O)OC)[C@@H]2c3cc4c(cc3[C@H]([C@@H]5[C@@H]2C(=O)OC5)O[C@H]6[C@@H]([C@H]([C@H]7[C@H](O6)COC(O7)c8cccs8)O)O)OCO4;
	InChI InChI=1S/C32H32O13S/c1-37-19-6-13(7-20(38-2)25(19)33)23-14-8-17-18(42-12-41-17)9-15(14)28(16-10-39-30(36)24(16)23)44-32-27(35)26(34)29-21(43-32)11-40-31(45-29)22-4-3-5-46-22/h3-9,16,21,23-24,26-29,31-35H,10-12H2,1-2H3/t16-,21+,23+,24-,26+,27+,28+,29+,31?,32-/m0/s1 ; Key:NRUKOCRGYNPUPR-PSZSYXFXSA-N ;
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Teniposide, sold under the brand name Vumon, is a chemotherapy medication used to treat acute lymphocytic leukemia (ALL) in children.^[1] It is a second line agent for this use.^[1] Other uses may include small cell lung cancer and lymphoma.^[2] It is given by injection into a vein.^[1]

Common side effects include low white blood cells, low red blood cells, low platelets, inflammation in the mouth, nausea, hair loss, bleeding, fever, and allergic reactions.^[1] Other side effects may include other cancers, tissue death at the site of injection, and low blood pressure.^[1] Use in pregnancy may harm the baby.^[1] It is in a class of drugs known as podophyllotoxin derivatives and is believed to work by interfering with the production of DNA.^[1]

Teniposide was approved for medical use in the United States in 1992.^[1] It has been sold in Europe since 1967 and Canada since 1984.^[2]^[3] In the United States it costs about 2,100 USD per 50 mg dose as of 2021.^[4] It is no longer commercially available in Canada.^[3]

References[edit]

^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k "Teniposide Monograph for Professionals". Drugs.com. Archived from the original on 16 August 2019. Retrieved 25 September 2021.
^ ^a ^b Ravina, Enrique (18 April 2011). The Evolution of Drug Discovery: From Traditional Medicines to Modern Drugs. John Wiley & Sons. p. 156. ISBN 978-3-527-32669-3. Archived from the original on 25 September 2021. Retrieved 25 September 2021.
^ ^a ^b Government of Canada, Health Canada (25 April 2012). "Drug Product Database Online Query". health-products.canada.ca. Archived from the original on 27 September 2021. Retrieved 26 September 2021.
^ "Teniposide Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 24 January 2021. Retrieved 25 September 2021.

[AHFS2021-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k "Teniposide Monograph for Professionals". Drugs.com. Archived from the original on 16 August 2019. Retrieved 25 September 2021.

[Rav2011-2] Ravina, Enrique (18 April 2011). The Evolution of Drug Discovery: From Traditional Medicines to Modern Drugs. John Wiley & Sons. p. 156. ISBN 978-3-527-32669-3. Archived from the original on 25 September 2021. Retrieved 25 September 2021.

[HC2021-3] Government of Canada, Health Canada (25 April 2012). "Drug Product Database Online Query". health-products.canada.ca. Archived from the original on 27 September 2021. Retrieved 26 September 2021.

[4] "Teniposide Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 24 January 2021. Retrieved 25 September 2021.

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