User:Mr. Ibrahem/Nortriptyline
Clinical data | |
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Trade names | Pamelor, Noritren, Nortrilen, others |
Other names | Desitriptyline; ELF-101; E.L.F. 101; N-7048 |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682620 |
License data | |
Pregnancy category |
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Routes of administration | By mouth |
Drug class | Tricyclic antidepressant (TCA) |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Bioavailability | 32–79[1] |
Protein binding | 92%[1] |
Metabolism | Liver |
Metabolites | 10-E-Hydroxynortriptyline |
Elimination half-life | 18–44 hours (mean 30 hours)[1] |
Excretion | Urine: 40%[1] Feces: minor[1] |
Identifiers | |
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Chemical and physical data | |
Formula | C19H21N |
Molar mass | 263.384 g·mol−1 |
3D model (JSmol) | |
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Nortriptyline, sold under the brand name Pamelor, among others, is a medication used to treat depression, neuropathic pain, attention deficit hyperactivity disorder (ADHD), stopping smoking, and anxiety.[2][3] It does not appear to be useful for young people with depression.[3] Nortriptyline is a less preferred treatment for ADHD and stopping smoking.[3] It is taken by mouth.[3]
Common side effects include dry mouth, constipation, blurry vision, sleepiness, low blood pressure with standing, and weakness.[3] Serious side effects may include seizures, an increased risk of suicide in those less than 25 years of age, urinary retention, glaucoma, mania, and a number of heart issues.[3] Nortriptyline may cause problems if taken during pregnancy.[3] Use during breastfeeding appears to be relatively safe.[2] It is a tricyclic antidepressant (TCA) and is believed to work by altering levels of serotonin and norepinephrine.[3]
Nortriptyline was approved for medical use in the United States in 1964.[3] It is available as a generic medication.[2] A month supply of nortriptyline at 75mg/day in the United Kingdom costs the NHS around £35.00 as of 2020.[2] In the United States the wholesale cost of this amount is about US$4.20.[5] In 2017, it was the 183rd most commonly prescribed medication in the United States, with more than three million prescriptions.[6][7]
References[edit]
- ^ a b c d e Thomas L. Lemke; David A. Williams (24 January 2012). Foye's Principles of Medicinal Chemistry. Lippincott Williams & Wilkins. pp. 588–. ISBN 978-1-60913-345-0. Archived from the original on 16 December 2019. Retrieved 15 August 2017.
- ^ a b c d e BNF (80 ed.). London: BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. pp. 395–396. ISBN 978-0-85711-369-6.
{{cite book}}
: CS1 maint: date format (link) - ^ a b c d e f g h i j k "Nortriptyline Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 28 March 2019. Retrieved 22 March 2019.
- ^ a b "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 1 December 2020. Retrieved 7 September 2020.
- ^ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 2019-03-06. Retrieved 3 March 2019.
- ^ "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.
- ^ "Nortriptyline Hydrochloride - Drug Usage Statistics". ClinCalc. Archived from the original on 8 July 2020. Retrieved 11 April 2020.