User:Mr. Ibrahem/Glucagon (medication)
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Clinical data | |
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Trade names | GlucaGen, Baqsimi, Gvoke, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682480 |
License data | |
Pregnancy category |
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Routes of administration | Nasal, intravenous (IV), intramuscular injection (IM), subcutaneous injection |
Drug class | Glycogenolytic[2] |
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Chemical and physical data | |
Formula | C153H225N43O49S |
Molar mass | 3482.747314 g·mol−1 |
3D model (JSmol) | |
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Glucagon is a medication and hormone.[4] As a medication it is used to treat low blood sugar, beta blocker overdose, calcium channel blocker overdose, and those with anaphylaxis who do not improve with epinephrine.[2] It is given by injection into a vein, muscle, or under the skin.[2] A version given in the nose is also available.[6]
Common side effects include vomiting.[2] Other side effects include low blood potassium and low blood pressure.[4] It is not recommended in people who have a pheochromocytoma or insulinoma.[2] Use in pregnancy has not be found to be harmful to the baby.[7] Glucagon is in the glycogenolytic family of medications.[2] It works by causing the liver to break down glycogen into glucose.[2]
Glucagon was approved for medical use in the United States in 1960.[2] It is on the World Health Organization's List of Essential Medicines.[8] The wholesale cost in the developing world is about US$25.75 a dose.[9] In the United Kingdom that dose costs the NHS about £11.52.[4] In the United States the wholesale cost of a dose is US$247.32.[10] It is a manufactured form of the glucagon hormone.[2]
References
[edit]- ^ a b "Glucagon Use During Pregnancy". Drugs.com. 16 October 2019. Retrieved 16 May 2020.
- ^ a b c d e f g h i j k "Glucagon". The American Society of Health-System Pharmacists. Archived from the original on 26 December 2016. Retrieved 8 December 2016.
- ^ "GlucaGen Hypokit 1 mg - Summary of Product Characteristics (SmPC)". (emc). 15 June 2015. Retrieved 16 May 2020.
- ^ a b c d British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 487. ISBN 9780857111562.
- ^ "WHOCC - ATC/DDD Index". www.whocc.no. Retrieved 16 September 2020.
- ^ Commissioner, Office of the (24 March 2020). "FDA approves first treatment for severe hypoglycemia that can be administered without an injection". FDA. Retrieved 16 May 2020.
- ^ "Glucagon (GlucaGen) Use During Pregnancy". www.drugs.com. Archived from the original on 27 December 2016. Retrieved 27 December 2016.
- ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
- ^ "Glucagon". International Drug Price Indicator Guide. Retrieved 8 December 2016.
- ^ "NADAC as of 2016-12-21 | Data.Medicaid.gov". Centers for Medicare and Medicaid Services. Archived from the original on 24 December 2016. Retrieved 27 December 2016.