User:Mr. Ibrahem/Betaxolol
Clinical data | |
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Pronunciation | be tax' oh lol[1] |
Trade names | Kerlone[1] |
AHFS/Drugs.com | Systemic: Monograph Eye: Monograph |
MedlinePlus | a609023 |
Pregnancy category |
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Routes of administration | By mouth, eye drop |
Drug class | Cardioselective beta blocker[1] |
Legal status | |
Legal status |
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Pharmacokinetic data | |
Bioavailability | 89% |
Metabolism | Liver |
Elimination half-life | 14–22 hours |
Excretion | Kidney (20%) |
Identifiers | |
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Chemical and physical data | |
Formula | C18H29NO3 |
Molar mass | 307.434 g·mol−1 |
3D model (JSmol) | |
Chirality | Racemic mixture |
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Betaxolol, sold under the brand name Kerlone among others, is a medication used to treat glaucoma and high blood pressure.[1] It reduces eye pressure by about 30%.[3] It is not a first line treatment for blood pressure.[4] It is take by mouth or used as an eye drop.[1]
Common side effects by mouth include slow heart rate, low blood pressure, tiredness, dizziness, depression, trouble sleeping, memory loss, and sexual dysfunction.[1] At high doses it can induce bronchospasm.[1] Common side effects from the eye drops include eye irritation.[2] Safety in pregnancy is unclear.[4] It is a selective beta1 receptor blocker.[1] As an eye drop it is thought to work by reducing the production of aqueous humor within the eye.[3]
Betaxolol was patented in 1975 and approved for medical use in 1983.[5] It is available as a generic medication.[1] In the United Kingdom a 5 ml bottle of eye drops costs the NHS about £2 as of 2021.[2] In the United States this amount costs about 21 USD.[6]
References[edit]
- ^ a b c d e f g h i j k l "Betaxolol". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 15 May 2021. Retrieved 10 January 2022.
- ^ a b c BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1224. ISBN 978-0857114105.
- ^ a b "Betaxolol (EENT) Monograph for Professionals". Drugs.com. Archived from the original on 24 January 2021. Retrieved 10 January 2022.
- ^ a b "Betaxolol (Systemic) Monograph for Professionals". Drugs.com. Archived from the original on 6 August 2021. Retrieved 10 January 2022.
- ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 461. ISBN 9783527607495. Archived from the original on 2017-09-08. Retrieved 2021-03-21.
- ^ "Betaxolol Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 6 October 2016. Retrieved 10 January 2022.