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C5orf36

C5orf36 is a protein that in humans is encoded by the gene C5orf36. It is also known as KIAA0825. The gene is located on chromosome 5, 5q15. The gene is about 478 kb long and produces 8 differents variants: 7 alternatively spliced, and one un-spliced version. The longest mRNA is 7240 bp long and produces a protein 1275 amino acids long. It has orthologs in most animals including zebrafish, but is not found in in bacteria or plants with the exception of Plasmodiophora brassicae.

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  Human chromosome 5 regions labeled.

Protein Structure

The protein contains no transmembrane or signal domains. It does contain one domain which is poorly understood, that belongs to the DUF4495 protein family.

References in Scientific Papers

No papers specifically explore the function of C5orf36. There are however two papers that found the gene C5orf36 was disrupted by other genes. Schilts et. al found it was disrupted by the gene DGAP242 in congenital hearing loss, but the paper suggests it is likely not the cause of the hearing loss. Crepel et al found it is disrupted in Autism Spectrum Disorder (ASD) along with CDH11 and GFOD2. There is no indication though that it is the cause of ASD or responsible for any of the symptoms. The article does mention that it has a haploinsufficiency score of 93%.

C5orf36 is a protein that in humans is encoded by the gene of the same name, located on chromosome 5, 5q15. It is a relatively fast mutating gene, compared to other coding genes. There is however one region which is highly conserved across the species that have the gene, known as DUF4495. It is predicted to be a protein that travels between the nucleus and the cytoplasm.

General Information

C5orf36 has one common alias KIAA0825. The gene is about 478 kb long and contains 22 exons. It produces 10 differents variants: 9 alternatively spliced, and one un-spliced version. The longest mRNA is 7240 bp long and produces a protein 1275 amino acids long. The protein is predicted to weigh about 147.8kDal. It has orthologs in most animals including Aplysia californica, but is not found outside animals with the possible exception of Plasmodiophora brassicae.

The Isoforms of C5orf36

Protein Information

The protein has a predicted weight of 147.8 kDal. , It does not contain a known nuclear localization signal but does contain a nuclear export signal. The subcellular localization for the protein is predicted to be the nucleus and the cytoplasm, which suggests that the protein shuttles back and forth across the nuclear membrane.

Expression

The mRNA for C5orf36 is expressed at relatively low rates.ref>Úhlen, M; Fagerberg, L; Hallström, B. M; Lindskog, C; Oskvold, P; Mardinoglu, A (2015). "Proteomics. Tissue-based map of the human proteome". Science. 347: 6220. doi:10.1126/science.1260419.</ref> The protein however is expressed at relatively high rates, especially in parts of the brain as well as adrenal glands and the thyroid.ref>Úhlen, M; Fagerberg, L; Hallström, B. M; Lindskog, C; Oskvold, P; Mardinoglu, A (2015). "Proteomics. Tissue-based map of the human proteome". Science. 347: 6220. doi:10.1126/science.1260419.</ref> This would suggest that the protein is not readily degraded and remains in the cell for long periods of time.

Notes for Ecology

Mesic Habitat: The only things that is sourced is the term xeric (not even what the article is about). Everything is relevant but the article is super short so... I would also consider it to be fairly neutral. The information is WWF so that is a decent source if somewhat inadequate for the only source for an article. The stub talk page only says that it is a stub and low importance. It's super short although potentially could be useful if it had more information. It needs to reference ecological importance. Important changes and reference to peer reviewed journal articles.