User:KO3320/Centrocone

This is the sandbox page where you will draft your initial Wikipedia contribution.

If you're starting a new article, you can develop it here until it's ready to go live.

If you're working on improvements to an existing article, copy only one section at a time of the article to this sandbox to work on, and be sure to use an edit summary linking to the article you copied from. Do not copy over the entire article. You can find additional instructions here.

Remember to save your work regularly using the "Publish page" button. (It just means 'save'; it will still be in the sandbox.) You can add bold formatting to your additions to differentiate them from existing content.

Bibliography sandbox

Article Draft

Centrocones are sub-cellular structures involved in the cell division of apicomplexan parasites.^[1] Centrocones are a nuclear sub-compartment in parasites of Taxoplasma gondii that work in apposition with the centrosome to coordinate the budding process in mitosis^[1]. The centrocone concentrates and organizes various regulatory factors involved in the early stages of mitosis, including the ECR1 and TgCrk5 proteins.^[2] The membrane occupation and recognition nexus 1 (MORN1) protein is also contained in this structure and is linked to human diseases, though not much is yet known about the connection between the centrocone and the MORN1 protein.

Centrocones are located in the nuclear envelope and contain spindles that are used in mitosis.^[1]^[3] Chromosomes are contained within these spindles of the centrocone throughout the cell cycle. ^[4]

References

^ ^a ^b ^c Brooks, Carrie F.; Francia, Maria E.; Gissot, Mathieu; Croken, Matthew M.; Kim, Kami; Striepen, Boris (2011-03-01). "Toxoplasma gondii sequesters centromeres to a specific nuclear region throughout the cell cycle". Proceedings of the National Academy of Sciences. 108 (9): 3767–3772. doi:10.1073/pnas.1006741108. ISSN 0027-8424.
^ Naumov, Anatoli; Kratzer, Stella; Ting, Li-Min; Kim, Kami; Suvorova, Elena S.; White, Michael W. (2017-09-06). Knoll, Laura J.; Boothroyd, John C. (eds.). "The Toxoplasma Centrocone Houses Cell Cycle Regulatory Factors". mBio. 8 (4). doi:10.1128/mBio.00579-17. ISSN 2161-2129.
^ Gubbels, Marc-Jan; Vaishnava, Shipra; Boot, Nico; Dubremetz, Jean-François; Striepen, Boris (2006-06-01). "A MORN-repeat protein is a dynamic component of the Toxoplasma gondii cell division apparatus". Journal of Cell Science. 119 (11): 2236–2245. doi:10.1242/jcs.02949. ISSN 1477-9137.
^ Farrell, Megan; Gubbels, Marc-Jan (2014-01). "The Toxoplasma gondii kinetochore is required for centrosome association with the centrocone (spindle pole)". Cellular Microbiology. 16 (1): 78–94. doi:10.1111/cmi.12185. ISSN 1462-5822. PMC 3933516. PMID 24015880. {{cite journal}}: Check date values in: |date= (help)

[:0-1] Brooks, Carrie F.; Francia, Maria E.; Gissot, Mathieu; Croken, Matthew M.; Kim, Kami; Striepen, Boris (2011-03-01). "Toxoplasma gondii sequesters centromeres to a specific nuclear region throughout the cell cycle". Proceedings of the National Academy of Sciences. 108 (9): 3767–3772. doi:10.1073/pnas.1006741108. ISSN 0027-8424.

[2] Naumov, Anatoli; Kratzer, Stella; Ting, Li-Min; Kim, Kami; Suvorova, Elena S.; White, Michael W. (2017-09-06). Knoll, Laura J.; Boothroyd, John C. (eds.). "The Toxoplasma Centrocone Houses Cell Cycle Regulatory Factors". mBio. 8 (4). doi:10.1128/mBio.00579-17. ISSN 2161-2129.

[3] Gubbels, Marc-Jan; Vaishnava, Shipra; Boot, Nico; Dubremetz, Jean-François; Striepen, Boris (2006-06-01). "A MORN-repeat protein is a dynamic component of the Toxoplasma gondii cell division apparatus". Journal of Cell Science. 119 (11): 2236–2245. doi:10.1242/jcs.02949. ISSN 1477-9137.

[4] Farrell, Megan; Gubbels, Marc-Jan (2014-01). "The Toxoplasma gondii kinetochore is required for centrosome association with the centrocone (spindle pole)". Cellular Microbiology. 16 (1): 78–94. doi:10.1111/cmi.12185. ISSN 1462-5822. PMC 3933516. PMID 24015880. {{cite journal}}: Check date values in: |date= (help)

[1]

[2]

[3]

[4]