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Honokiol and its structural isomer magnolol are both compounds isolated from the bark of trees belonging to the Family Magnoliaceae.

Biology

Chemistry

Use in Traditional Medicine

Bark from various species of magnolia trees has been used in traditional Asian medicine for centuries. Use of the magnolia tree is particularly popular in traditional Chinese medicine as well as Japanese Kampo.^[1] In China, magnolia bark is called Houpu.^[2] A popular medicinal compounds containing honokiol from China is Banxia Houpu Tan (半夏厚朴丸); while in Japan, there are Saiboku-to(柴朴湯) and Hange-koboku-to (半夏厚朴湯).^[2] ^[1] These compounds have been used to treat gastrointestinal disorders, anxiety, depression, insomnia, and many other disorders.

Use in Modern Medicine

References

^ ^a ^b Maruyama, Yuji; Kuribara, Hisashi; Morita, Makoto; Yuzurihara, Mitsutoshi; Weintraub, Susan T. (1998). "Identification of Magnolol and Honokiol as Aniolytic Agents in Extracts of Saiboku-to, an Oriental Herbal Medicine". Journal of Natural Products. 61 (1): 135–138. doi:10.1021/np9702446. PMID 9461663.{{cite journal}}: CS1 maint: date and year (link)
^ ^a ^b >Lee, Young-Jung; Lee, Yoot Mo; Lee, Chong-Kil; Jung, Jae Kyung; Han, Sang Bae; Hong, Jin Tae (2011). "Therapeutic applications of compounds in the Magnolia family". Pharmacology & Therapeutics. 130 (2): 157–176. doi:10.1016/j.pharmthera.2011.01.010. PMID 21277893.{{cite journal}}: CS1 maint: date and year (link)

[Maruyama-1] Maruyama, Yuji; Kuribara, Hisashi; Morita, Makoto; Yuzurihara, Mitsutoshi; Weintraub, Susan T. (1998). "Identification of Magnolol and Honokiol as Aniolytic Agents in Extracts of Saiboku-to, an Oriental Herbal Medicine". Journal of Natural Products. 61 (1): 135–138. doi:10.1021/np9702446. PMID 9461663.{{cite journal}}: CS1 maint: date and year (link)

[Lee-2] >Lee, Young-Jung; Lee, Yoot Mo; Lee, Chong-Kil; Jung, Jae Kyung; Han, Sang Bae; Hong, Jin Tae (2011). "Therapeutic applications of compounds in the Magnolia family". Pharmacology & Therapeutics. 130 (2): 157–176. doi:10.1016/j.pharmthera.2011.01.010. PMID 21277893.{{cite journal}}: CS1 maint: date and year (link)

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[2]