User:JessicaVoiceDisorders/sandbox
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Laryngopharyngeal Reflux
[edit]LPR is the retrograde flow of gastric contents into the larynx, oropharynx and/or the nasopharynx.LPR causes respiratory symptoms such as cough and wheezing[1] and is often associated with head and neck complaints such as dysphonia, globus pharyngeus, and dysphagia.[2] LPR may play a role in other diseases such as sinusitis, otitis media, and rhinitis,[6] and can be a comorbidity of asthma.[5] While LPR is commonly used interchangeably with gastroesophageal reflux disease (GERD), it presents with a different pathophysiology.[3]
Signs and Symptoms
[edit]LPR is a chronic and intermittent disease in children [1]. LPR in children is commonly concomitant with laryngeal disorders such as laryngomalacia, subglottic stenosis and recurrent papillomatosis [1].
Diagnosis
[edit]LPR presents with non-specific symptoms and signs that make differential diagnosis difficult to achieve. Furthermore, symptoms of the disorder overlap greatly with symptoms of other disorders. Therefore, LPR is under-diagnosed and under-treated.[4]
There is no agreed-upon assessment technique to identify LPR in children [1]. Of these debated diagnostic tools, multichannel intraluminal impedance with pH monitoring (MII-pH) demonstrates relative strengths as it recognizes both acid and non-acid reflux [1]. A more common technique that is used is 24-h dual probe pH monitoring. Both of these tools are expensive and are therefore not widely used [1].
Questionnaires can be administered to receive information about the patient's medical history as well as their symptomatology. The following questionnaires may be used: Reflux Symptom Index (RSI), Quality-of-Life Index (QLI) for LPR, Glottal Closure/Function Index (GCI) and Voice Handicap Index (VHI) [3]. Other, more invasive tests, such as fibre-optic transnasal laryngoscopy, 24-hour ambulatory dual probe pHmetry, pharyngeal pHmetry, transnasal esophagoscopy (TNE) and biopsy may be used.[3] A noninvasive test for diagnosis of LPR is the collection of refluxate where the refluxed material is collected and analyzed.[7] Another noninvasive diagnostic test that can be used is an empirical trial of proton-pump inhibitor therapy; however, this test is mostly successful in diagnosing GERD. [3]
In the laryngopharyngeal reflux (LPR) page, I plan to add the following:
1) Make a clear distinction between LPR and GERD. [3]
2) Discuss the prevalence of LPR. [5]
3) Add a section on LPR in the paediatric population, focusing on assessment. [1]
4) Discuss the role of helicobactor pylori in LPR. [6]
References
[edit]- ^ a b c d e f g Galluzzi, F.; Schindler, A.; Gaini, R.M.; Garavello, W. (2015). "The assessment of children with suspected laryngopharyngeal reflux: An Otorhinolaringological perspective". International journal of pediatric otorhinolaryngology. 79 (10): 1613–1619. doi:10.1016/j.ijporl.2015.07.037. PMID 26279249.
- ^ Dhillon, VK; Akst, LM (August 2016). "How to Approach Laryngopharyngeal Reflux: An Otolaryngology Perspective". Current gastroenterology reports. 18 (8): 44. doi:10.1007/s11894-016-0515-z. PMID 27417389.
- ^ a b c d e Johnston, N.; Dettmar, P.W.; Strugala, V.; Allen, J.E.; Chan, W.W. (2013). "Laryngopharyngeal reflux and GERD". Annals of the New York Academy of Sciences. 1300 (1): 71–79. doi:10.1111/nyas.12237.
- ^ Fraser-Kirk, K (2017). "Laryngopharyngeal reflux: A confounding cause of aerodigestive dysfunction". Australian family physician. 46 (1): 34–39. PMID 28189129.
- ^ Fraser-Kirk, K (2017). "Laryngopharyngeal reflux: A confounding cause of aerodigestive dysfunction". Australian family physician. 46 (1): 34–39. PMID 28189129.
- ^ Campbell, R.; Kilty, S.J.; Hutton, B.; Bonaparte, J.P. (2017). "The Role of Helicobacter pylori in Laryngopharyngeal Reflux". Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 156 (2): 255–262. doi:10.1177/0194599816676052. PMID 27803078.