User:Jenil21/CCR4-Not
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Article Draft.
[edit]Lead
[edit]Ccr4–Not complex plays an important role in mRNA decay and protein quality control in the cytoplasm. Ccr4-Not possesses exonuclease activity that shortens the poly(A) tail found at the 3' end of almost every eukaryotic mRNA. In yeast the complex has nine core subunits, comprising Ccr4 (carbon catabolite repression), Caf proteins (Ccr4 associated factor) (Caf1, Caf40, Caf130) and Not proteins (Not1, Not2, Not3, Not4, and Not5).
Article body
[edit]In mammalian cell, it has a function in the regulation of the cell cycle, chromatin modification, activation and inhibition of transcription initiation, control of transcription elongation, RNA export, nuclear RNA surveillance, and DNA damage repair in nucleus.
References
[edit]Chalabi Hagkarim, Nafiseh; Grand, Roger J. (2020-10-29). "The Regulatory Properties of the Ccr4–Not Complex". Cells. 9 (11): 2379.
doi:10.3390/cells9112379. ISSN 2073-4409. PMC 7692201. PMID 33138308.
Stowell, James A. W.; Webster, Michael W.; Kögel, Alexander; Wolf, Jana; Shelley, Kathryn L.; Passmore, Lori A. (2016-11-15). "Reconstitution of Targeted Deadenylation by the Ccr4-Not Complex and the YTH Domain Protein Mmi1". Cell Reports. 17 (8): 1978–1989.
doi:10.1016/j.celrep.2016.10.066. ISSN 2211-1247. PMC 5120349. PMID 27851962.
Collart, Martine A (2003-08-14). "Global control of gene expression in yeast by the Ccr4-Not complex". Gene. 313: 1–16.