User:Immcarle141/Addressin
Addressin is a lesser-used term to describe the group of adhesion molecules that are involved with lymphocyte homing, commonly found at high-endothelial venules (HEVs) where lymphocytes exit the blood and enter the lymph node.[1][2]
___ .[3]
Addressins physically bind to mobile lymphocytes to guide them to the HEVs.[1] Examples of molecules that are often referred to as addressins are CD34 and GlyCAM-1 on HEVs in peripheral lymph nodes, and MAdCAM-1 on endothelial cells in the intestine.[2]
MAdCAM-1
[edit]Therapies
[edit]In inflammatory bowel diseases, MAdCAM-1 can be overexpressed on the endothelial cells of intestinal mucosa and gut‐associated lymphoid tissue, leading to excessive inflammation in the gut.[4] A potential therapeutic target to manage these diseases could be the MAdCAM-1 molecules that are expressed on these cells and bring in lymphocytes. One example of a potential therapy is the fully human monoclonal antibody ontamalimab that targets and binds to MAdCAM-1, preventing it from interacting with the integrins on the surface of the lymphocytes.[5]
PNAd
[edit]Peripheral node addressins (PNAd) are carbohydrate residues that are lymphocyte homing receptor ligands that are expressed on the HEVs of peripheral lymph nodes.[6] These proteins collectively bind to L-selectin to guide lymphocytes such as mature naïve B and T cells into the lymph node.[3][7][8] During the development of secondary lymphoid organs, PNAd expression is upregulated following the upregulation and subsequent downregulation of MAdCAM-1 on HEVs.[8] PNAd expression, as well as the expression of MAdCAM-1, is dependent on lymphotoxin signaling in the HEVs of lymph nodes.[8]
- ^ a b Bevilacqua, M P (1993-04-01). "Endothelial-Leukocyte Adhesion Molecules". Annual Review of Immunology. 11 (1): 767–804. doi:10.1146/annurev.iy.11.040193.004003. ISSN 0732-0582.
- ^ a b Punt, Jenni (2019). Kuby immunology. Sharon A. Stranford, Patricia P. Jones, Judith A. Owen (Eighth ed.). New York. ISBN 978-1-4641-8978-4. OCLC 1002672752.
{{cite book}}: CS1 maint: location missing publisher (link) - ^ a b Berg, E. L.; Robinson, M. K.; Warnock, R. A.; Butcher, E. C. (1991-07-15). "The human peripheral lymph node vascular addressin is a ligand for LECAM-1, the peripheral lymph node homing receptor". Journal of Cell Biology. 114 (2): 343–349. doi:10.1083/jcb.114.2.343. ISSN 0021-9525.
- ^ Arihiro, Seiji; Ohtani, Haruo; Suzuki, Manabu; Murata, Masahiro; Ejima, Chieko; Oki, Motoji; Kinouchi, Yoshitaka; Fukushima, Kouhei; Sasaki, Iwao; Nakamura, Shiro; Matsumoto, Takayuki (2002). "Differential expression of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in ulcerative colitis and Crohn's disease". Pathology International. 52 (5–6): 367–374. doi:10.1046/j.1440-1827.2002.01365.x. ISSN 1440-1827.
- ^ Picardo, Sherman; Panaccione, Remo (2020-04-02). "Anti-MADCAM therapy for ulcerative colitis". Expert Opinion on Biological Therapy. 20 (4): 437–442. doi:10.1080/14712598.2020.1691520. ISSN 1471-2598. PMID 31709847.
- ^ Picker, L J; Butcher, E C (1992-04-01). "Physiological and Molecular Mechanisms of Lymphocyte Homing". Annual Review of Immunology. 10 (1): 561–591. doi:10.1146/annurev.iy.10.040192.003021. ISSN 0732-0582.
- ^ Lechleitner, S.; Kunstfeld, R.; Messeritsch-Fanta, C.; Wolff, K.; Petzelbauer, P. (September 1999). "Peripheral lymph node addressins are expressed on skin endothelial cells". The Journal of Investigative Dermatology. 113 (3): 410–414. doi:10.1046/j.1523-1747.1999.00696.x. ISSN 0022-202X. PMID 10469342.
- ^ a b c Randall, Troy D.; Carragher, Damian M.; Rangel-Moreno, Javier (2008-03-27). "Development of Secondary Lymphoid Organs". Annual Review of Immunology. 26 (1): 627–650. doi:10.1146/annurev.immunol.26.021607.090257. ISSN 0732-0582. PMC 2590644. PMID 18370924.
{{cite journal}}: CS1 maint: PMC format (link)