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Transmembrane protein 151B
[edit]Transmembrane protein 151B is the protein encoded by the TMEM151B gene.[1]
Nomenclature
[edit]The Transmembrane protein 151B gene is also known as TMEM151B, C6orf137, and bA444E17.5.[1]
Gene
[edit]The gene is located on the positive strand of chromosome 6 at the location 6p21.1 from the chromosome position 44270450 to 44279444, for a total length of 8,995 base pairs.[2] It is a complex locus that contains both TMEM151B and SPATS1. [3] TMEM151B has one paralog: TMEM151A.[4]
Transcript
[edit]The mRNA contains 3 exons, with a transcribed mRNA length of 4911bp, and the coding region containing 1701bp. [2]
![](http://upload.wikimedia.org/wikipedia/commons/7/73/Gene_diagram_TMEM151B.png)
Protein
[edit]![](http://upload.wikimedia.org/wikipedia/commons/thumb/2/21/Protien_2D_protter.png/220px-Protien_2D_protter.png)
![](http://upload.wikimedia.org/wikipedia/commons/thumb/8/8b/TMEM151B_Afold_predicted_structure.png/220px-TMEM151B_Afold_predicted_structure.png)
The protein has a length of 566 amino acids and contains two transmembrane domains.[1] According to Compute pI/Mw, molecular weight of approximately 61 kDa, which matches the weight listed on NCBI, and a theoretical isoelectric point of 6.72[6][1]. The human TMEM151B protein composition is poor in lysine and arginine, lysine comprising 1.4% of the amino acids and arginine making up 0.8% of the total protein. The mouse ortholog is also arginine poor. [7]
Expression
[edit]![](http://upload.wikimedia.org/wikipedia/commons/thumb/1/19/TMEM151B_RNA_expression_mouse_brain.png/220px-TMEM151B_RNA_expression_mouse_brain.png)
RNA-seq gene expression profiling shows high expression in the brain, and notable expression in the testes.[9] NCBI geo profiles similarly show localization to the brain tissues.[10] Within the mouse brain, TMEM151B has high expression particularly within the cerebellum, medulla, and olfactory bulb according to the Allen Brain Atlas. [8]
Protein interactions
[edit]The TMEM151B protein interacts with one other protein according to BioGRID.[11]
- SREBF2- a transcription factor precursor which is imbedded in the endoplasmic reticulum membrane; activates genes involved with cholesterol biosynthesis.[12]
Homology and Evolution
[edit]![](http://upload.wikimedia.org/wikipedia/commons/thumb/4/41/TMEM151B_evolution_rate_graph.png/220px-TMEM151B_evolution_rate_graph.png)
The TMEM151B gene is conserved within most vertebrates, and appears to be conserved within some invertebrates. Its paralog, TMEM151A, has a 47.7% sequence identity with TMEM151B.[4][13] The evolution rate is relatively slow: between the rate of change in fibrinogen alpha and cytochrome c.[4][14]
![](http://upload.wikimedia.org/wikipedia/commons/thumb/6/64/Phylo_tree_TMEM151B_annotated.png/220px-Phylo_tree_TMEM151B_annotated.png)
![](http://upload.wikimedia.org/wikipedia/commons/thumb/6/67/TMEM151B_orthologs.png/900px-TMEM151B_orthologs.png)
Research
[edit]Alternative splicing of TMEM151B along with 4 other genes were linked to colorectal cancer[15]. It was also found to be up-regulated in post-menopausal breast cancer[16][17]. A SNP found within TMEM151B is associated with the development of lean muscle.[18]
References
[edit]- ^ a b c d "transmembrane protein 151B [Homo sapiens] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2021-09-29.
- ^ a b "Homo sapiens transmembrane protein 151B (TMEM151B), mRNA - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2021-09-29.
{{cite web}}
: CS1 maint: url-status (link) - ^ "AceView: Gene:TMEM151BandSPATS1, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView". www.ncbi.nlm.nih.gov. Retrieved 2021-10-04.
- ^ a b c d "BLAST: Basic Local Alignment Search Tool". blast.ncbi.nlm.nih.gov. Retrieved 2022-01-13.
- ^ "Protter - interactive protein feature visualization". wlab.ethz.ch. Retrieved 2022-01-13.
- ^ "ExPASy - Compute pI/Mw tool". web.expasy.org. Retrieved 2022-01-13.
- ^ "SAPS < Sequence Statistics < EMBL-EBI". www.ebi.ac.uk. Retrieved 2022-01-13.
- ^ a b "ISH Data :: Allen Brain Atlas: Mouse Brain". mouse.brain-map.org. Retrieved 2022-01-13.
- ^ "TMEM151B transmembrane protein 151B [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-01-13.
- ^ "GDS596 / 213678_at". www.ncbi.nlm.nih.gov. Retrieved 2022-01-13.
- ^ "TMEM151B (RP11-444E17.5) Result Summary | BioGRID". thebiogrid.org. Retrieved 2022-01-13.
- ^ "SREBF2 Gene - GeneCards | SRBP2 Protein | SRBP2 Antibody". www.genecards.org. Retrieved 2022-01-13.
- ^ "Clustal Omega < Multiple Sequence Alignment < EMBL-EBI". www.ebi.ac.uk. Retrieved 2022-01-13.
- ^ "TimeTree :: The Timescale of Life". www.timetree.org. Retrieved 2022-01-13.
- ^ Liu, Jingwei; Li, Hao; Shen, Shixuan; Sun, Liping; Yuan, Yuan; Xing, Chengzhong (2018). "Alternative splicing events implicated in carcinogenesis and prognosis of colorectal cancer". Journal of Cancer. 9 (10): 1754–1764. doi:10.7150/jca.24569. ISSN 1837-9664.
- ^ Carter, JM; Nair, AA; Davila, JI; Heinzen, EP; Hoskin, TL; Winham, SJ; Radisky, DC; Visscher, DW; Degnim, AC (2019-02-15). "Abstract P3-08-10: A unique coding and non-coding benign breast transcriptome in post-menopausal ER+ breast cancer". Poster Session Abstracts. American Association for Cancer Research. doi:10.1158/1538-7445.sabcs18-p3-08-10.
- ^ Qian, Da; Zheng, Qinghui; Wu, Danping; Ye, Buyun; Qian, Yangyang; Zhou, Tao; Qiu, Jie; Meng, Xuli (2021-05-13). "Integrated Analysis of ceRNA Network Reveals Prognostic and Metastasis Associated Biomarkers in Breast Cancer". Frontiers in Oncology. 11. doi:10.3389/fonc.2021.670138. ISSN 2234-943X.
{{cite journal}}
: CS1 maint: unflagged free DOI (link) - ^ Pei, Yu-Fang; Hu, Wen-Zhu; Yang, Xiao-Lin; Wei, Xin-Tong; Feng, Gui-Juan; Zhang, Hong; Shen, Hui; Tian, Qing; Deng, Hong-Wen; Zhang, Lei (2019-11-23). "Two functional variants at 6p21.1 were associated with lean mass". Skeletal Muscle. 9 (1). doi:10.1186/s13395-019-0212-3. ISSN 2044-5040.
{{cite journal}}
: CS1 maint: unflagged free DOI (link)