User:Goryanin
IGOR GORYANIN
[edit]Igor Goryanin holds a Henrik Kascer Chair in Computational Systems Biology at the University of Edinburgh, and leads the Computational Systems Biology group, School of Informatics. Igor is also Director for the Edinburgh Centre for Bioinformatics and Co-director for the Centre for Systems Biology at Edinburgh.
IGOR GORYANIN’S MAJOR RESEARCH INTERESTS AND PROJECTS
[edit]- Systems biology: Reconstruction, modelling and analysis of biological networks based on functional genomics data and literature.
- Systems Biology Informatics Infrastructure development
- Life science Informatics: Data mining and data integration of biological and pharmaceutical-related databases.
- Software and algorithms for modelling and stimulation, visualization and optimisation of complex systems
- Bioenergy research: Optimisation of bio-fuel cell devices, which uses the ability of some micro-organisms and enzymes to convert organic matter into electricity directly. (link to MFC webpage)
- Systems Oncology: Application of modelling and analysis of pathways in human tissues in order to predict response to anti-cancer treatment and to develop personalised therapies, distance learning and diagnostics in cancer. (link to systems oncology page).
CAREER
[edit]Igor graduated (MSc) in 1985 as an applied mathematician from the Computer Science Department, [Moscow Engineering Physical Institute] (MEPHI), where he was developing numerical methods and algorithms for analysis of stiff ordinary differential equations. Igor Goryanin spent more then twelve years working in the Institute of Biophysics, Russian Academy of Science and obtained his PhD in 1995 at the same Institute. During this time he developed DbSolve (LINK ask Oleg), a software for mathematical stimulation and analysis of the cellular metabolism and regulation (Igor is an author for DbSolve). From 1989-1995 he was also CEO and co-founder of Biobank Inc., Russia.
In 1995-1997 Igor worked as a Visiting Computer Scientist at the Mathematics & Computer Science Division, [Argonne National Laboratories].
He joined GlaxoSmithKline (formerly known as GlaxoWellcome)in 1997, working firstly as Senior Bioinformatics Analyst/Scientist (1997-1999), a Senior Research Bioinformatics Scientist, Group Leader, Project manager (1999-2001) and later as a Head of Cell Simulations and Pathway Modelling (2001-2005). During his time at GlaxoSmithKline, Igor was working on application of modelling and informatics techniques to the pharmaceutical research and development and drugs manufacturing industry. The whole cell modelling of organisms approach developed by Igor has been successfully used to improve drug R&D and manufacturing process in production plants. i.e. designing anti-microbial assays and anti-microbial drug targets identification, rational organism design, rational biomarker design and target prioritisation, reconstructing cellular networks for cancers, metabolic and lipid disorders.
In 2005 Goryanin moved to Edinburgh to take the position of a Henrik Kascer Chair in Computational Systems Biology. In 2006 Igor developed one of the first [Masters courses in Computational Systems Biology] in the UK, currently taught at the University of Edinburgh.
Igor is co-founder of the International E. coli alliance (IECA). Goryanin and his group are currently involved in several high profile international collaborations:
- SBML - The Systems Biology Markup Language (SBML) is a computer-readable format for representing models of biochemical reaction networks. SBML is applicable to metabolic networks, cell-signalling pathways, regulatory networks, and many others.
- SBGN Systems Biology Graphical Notation aims to help standardize a graphical notation for computational models in systems biology.
- BioSim , Network of Excellence established by the European Commission under its 6th Framework Programme. The main objective of the Network is to demonstrate how the use of modern simulation techniques can lead to a more rational drug development process, improved treatment procedures, and a reduction in the need for animal experiments.
- RiboSYS project, funded under FP6, uses systems biology approaches to model pre-messenger RNA and pre-ribosomal RNA metabolism in Saccharomyces cerevisiae and so aid the understanding of these complex cellular pathways.
- EC-MOAN , the project funded under FP6 aims to develop an integrated model of the stress response system of E. coli, including key metabolic, genetic and signalling modules.
- International RTK consortium - The Receptor Tyrosine Kinase (RTK) Networks Consortium is an organization to facilitate and co-ordinate international efforts for the continued understanding of RTK signalling pathways and its relationship to human pathologies.
- Riken Genomic Research Centre (Japan) – collaboration in breast cancer treatment and personalised treatment.
- Systems Biology Institute in Tokyo - disease treatment and drug discovery research.
- Institute for Systems Biology SpB (Russia) – kinetic modelling for complex biological systems(with applications for the drug discovery).
RECENT PUBLICATIONS (2006 -2007)
[edit]J.Wolf , S. Dronov , F.Tobin , I. Goryanin (2007) “The impact of the regulatory design on the response of epidermal growth factor receptor mediated signal transduction towards oncogenic mutations”. FEBS Journal, 274 (21) : 5505-17.
Hongwu Ma, Anatoly Sorokin, Alexander Mazein, Alex Selkov, Evgeni Selkov, Oleg Demin, Igor Goryanin (2007) “The Edinburgh human metabolic network reconstruction and its functional analysis”, Molecular Systems Biology, 3:135.
Goryanin I. (2006) Cellular Modelling of Biochemical Processes in Microorganisms” In “Microbial Proteomics: Functional Biology of Whole Organism” Editors Ian Humphrey-Smith and Michael Hecker, John Wiley & Sons.
S.L. Moodie, A.A. Sorokin, I. Goryanin, and P. Ghazal (2006) “Graphical Notation to describe the Logical Interactions of Biological Pathways”, Journal of Integrative Bioinformatics, 3(2): p. 36.
Metelkin, Е., Goryanin, I, Demin, О.(2006) “Mathematical Modeling of Mitochondrial Adenine Nucleotide Translocase”, Biophysical Journal, 15; 90 (2): 423-32.
Sorokin A., Paliy K., Selkov A., Demin O., Dronov S., Ghazal P. and Goryanin I. (2006) “The Pathway editor: A tool for managing complex biological networks”, IBM Journal research & Development. 6 :561 – 575.
Goryanin I, Lebedeva GV, Mogilevskaya EA, Metelkin EA, Demin OV. (2006) ”Cellular kinetic modeling of the microbial metabolism”. Methods Biochem Anal.:49:437-88.
Sinha Y, Kolupaev A, Demin O, Earnshaw D, Tobin F, West J, Martin JD, Qiu C, Liu WS, DeWolf WE Jr, Tew D, Goryanin I, (2006) “The kinetic model of the shikimate pathway as a tool to optimize enzyme assays for high-throughput screening”. Biotechnol. Bioeng. Nov : 95(4): 560-73.
Mogilevskaya E., Demin O., Goryanin I., (2006) “Kinetic Model of Mitochondrial Krebs Cycle: Unravelling the Mechanism of Salicylate Hepatotoxic Effects”, Journal of Biological Physics, 27, 245-271.
BOOKS AND BOOK CHAPTERS
[edit]"Goryanin I and Demin O “Kinetic Modelling in Systems Biology” Chapman & Hall/CRC, 2008, in press.
"Modelling and Simulations of biological pathways: pharmaceutical applications," Editors Martyn Ford, David Livingstone, John Dearden, Ha Van de Waterbbemd, Blackwell Publishing, 2003.
"Applications of whole cell and large pathway mathematical models in the pharmaceutical industry" Metabolic Engineering in the Post-Genomic Era, Editors B. Kholodenko and H. Westerhoff, Horizon Bioscience, UK, 2003.