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The most common type of dementia is Alzheimer’s disease, which is a progressive neurodegenerative disease that slowly destroys memory and thinking skills. An estimated 7 million Americans have Alzheimer’s --- 73% are 75 years of age and older, with 2/3rds being women. The causes of Alzheimer’s are age-related, genetics, environmental causes, eating habits, lack of sleep, alcohol, smoking, and lack of exercise. Pharmacological interventions such as acetylcholinesterase and N-methyl-D-aspirate are used to delay the progression of the disease while AI and neuroimaging technologies in exercise interventions are used to decrease the condition.

    An article titled, “Exercise Intervention for Alzheimer’s Disease: Unraveling Neurobiological Mechanisms and Assessing Effects” written by Jianchang Ren and Haili Xiao provided a table that includes the intensity, frequency, and outcomes of various exercises conducted by others to determine the effects of exercising for people with Alzheimer’s Disease. Moderate exercise on a treadmill twice a week for 30 minutes, totaling 16 weeks, shows improvements in functional capacity <ref>(Arcouverde, C 2014). Another trial would be moderate exercise while cycling for 3 months, 3 times a week for 40 minutes which shows cognitive function improvement (Yang, S.Y. 2015). Lastly, low-intensity walking for 10 weeks, 3 times a week for 30 minutes showed improvement in communication performance Ren, Jianchang; Haili, Xiao (December 2023). "Exercise Intervention for Alzheimer's Disease: Unraveling Neurobiological Mechanisms and Assessing Effects". 13 (12): 2285. {{cite journal}}: Cite journal requires |journal= (help).

    Another article, “Effects of low- and high-intensity physical exercise on physical and cognitive functions in older persons with dementia: a randomized controlled trial” written by L.M.J. Sanders and E.J.A. Scherder is a randomized control trial determining the effects of exercise on cognitive and physical functions in patients that have dementia. During the trial, Sanders and Scherder conducted a 24-week aerobic and strength training program, 12 weeks of low-strength, and 12 weeks of high-intensity phases. There were two groups --- exercise group and attention-matched control participants who participated in these trial runs 3 times a week. The exercise group walked and did lower limb strength training while the attention-matched control participants performed flexibility exercises and recreational activities. Each session was assessed by physical endurance, gait speed, mobility, balance, leg strength and cognitive verbal memory, visual memory, executive function, inhibitory function, inhibitory control, and psychomotor speed. The trial resulted in 60% mean attendance with no significant effects between the two groups tested and exercising did not have an effect on physical or cognitive function for Alzheimer’s carriers. sanders, mj (march 2020). ""Effects of Low- and High-Intensity Physical Exercise on Physical and Cognitive Function in Older Persons with Dementia: A Randomized Controlled Trial." Alzheimer's Research & Therapy". 12 (1): 1–15. {{cite journal}}: Check date values in: |date= (help); Cite journal requires |journal= (help)

    Lastly, “Dementia Risk and Dynamic Response to Exercise” written by Eric D. Vidoni, Casey S. John and others is a non-randomized trial that examines the effect of aerobic exercise on brain blood flow and blood neurotrophic factors associated with exercise response and brain function in older adults with or without Alzheimer’s Disease. A total of 69 older adults completed a single 15-minute moderate-intensity aerobic exercise in which the trial lasted from October 2019 through October 2021. The primary outcome measure of the study was in the Cerebral flow in the Cortical grey matter in which an MRI arterial spin labeling was used. Additionally, the secondary outcome was based on changes in blood neurotrophin concentrations of insulin-like factors-1 (IGF-1), vascular endothelial growth factor (VEGF), and brain-derived neurotrophic (BDNF). The results after the trial were conducted determined that both Alzheimer’s carriers and non-carriers showed similar outcomes effects from exercising which increased cerebral blood flow and neurotrophic response Vidoni, Eric (july 2022). "Dementia risk and dynamic response to exercise: A non-randomized clinical trial". 17 (7): 1–14. {{cite journal}}: Check date values in: |date= (help); Cite journal requires |journal= (help).

    Dementia and Alzheimer’s Diseases are incurable, however, some medications slow down the progression of these diseases. Additionally, studies have shown that exercising significantly and positively affects cognitive and physical health. Exercising has shown that it can lower the risk of developing Alzheimer’s, improve memory, reasoning, and processing speed, boost mood and reduce symptoms of depression which are often associated with Alzheimer's, and modify Amyloid B (a protein that’s a key factor in Alzheimer’s Disease) inflammation, synthesis, and release neurotrophins, lastly, exercising increase cerebral blood flow.