User:Fk924/EEA1
EEA1 is a RAB5A effector protein which binds via an N-terminal zinc finger domain and is required for fusion of early and late endosomes and for sorting at the early endosome level.
EEA1 plays a role in endocytosis and is recruited by Rab5-GTP to endosomal membranes[1]. EEA1 may be regulated through monoubiquination, affecting endosome fusion and trafficking[2]. Ubiquitin selective segregase p97 may regulate EEA1's tethering ability, affecting its endosome trafficking and morphplogy.
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[edit]- ^ Stefan, Christopher; Audhya, Anjon; Emr, Scott D. (2010-01-01), Bradshaw, Ralph A.; Dennis, Edward A. (eds.), "Chapter 138 - FYVE Domains in Membrane Trafficking and Cell Signaling", Handbook of Cell Signaling (Second Edition), San Diego: Academic Press, pp. 1111–1121, ISBN 978-0-12-374145-5, retrieved 2023-05-16
- ^ Ramanathan, Harish N.; Zhang, Guofeng; Ye, Yihong (2013-05-23). "Monoubiquitination of EEA1 regulates endosome fusion and trafficking". Cell & Bioscience. 3 (1): 24. doi:10.1186/2045-3701-3-24. ISSN 2045-3701. PMC 3673817. PMID 23701900.
{{cite journal}}: CS1 maint: unflagged free DOI (link)