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  • With partnerships across the globe, and long-term research and development goals, Dr. Wirth is helping lead the charge against the malaria parasite
  • Additionally, Dr. Wirth was named a Fellow of the American Association for the Advancement of Science (AAAS) in 2019, for her work with the human malaria parasite, Plasmodium falciparum.[1]
  • Wirth's contributions to research on the malaria parasite have been very beneficial in the process of understanding the molecular mechanisms in protozoan parasites. Her lab's end goal is to find a specific intervention for parasites, by analyzing the genes impacting the severity of parasites and their drug resistance. [2]
  • The issue of drug resistance in these parasites is very prevalent, due to the fact that the drug resistant parasites are found worldwide. This poses an additional threat to third-world countries where new medicine and healthcare are hard to come by.[2]
  • One of the biggest discoveries her lab has made recently is that the expression of a P-glycoprotein type molecule encoded by a resistance gene may play a large role in drug resistance. Protozoan parasites with an overexpression of these genes often correlate to higher drug resistance. Dr. Wirth's lab is currently testing this hypothesis to further our medical expertise when combatting these parasites.[2]
  • Her work has made a large impact on the fight against globally infectious diseases, both scientifically and educationally. With the help of Dr. Wirth's Lab at Harvard, a new study was published in 2019 showing a vaccine that targets the malaria germ cells on red blood cells could help prevent further spread of malaria.[3] The World Health Organization (WHO) is recommending the production and rollout of a vaccine that protects against the malaria parasite (Plasmodium falciparum).[4]
  • Born in Racine, Wisconsin and went to University of Wisconsin, Madison for her undergraduate degree in Zoology and Chemistry. She received her Ph.D. in 1978 from Massachusetts Institute of Technology in Cell Biology and Biochemistry.[2]
  • Other awards include:
  • ""Fighting Global Infectious Disease" by Dr. Dyann Wirth". 14 October 2015.{{cite web}}: CS1 maint: url-status (link)
  • "Science Bulletins: Malaria—Natural Selection and New Medicine". 17 August 2012.{{cite web}}: CS1 maint: url-status (link)

Publications

[edit]
  • Malaria: Biology in the Era of Eradication (2017)[7]
  • Host-mediated Selection Impacts the Diversity of Plasmodium falciparum Antigens within Infections[8]
  • Dramatic Changes in Malaria Population Genetic Complexity in Dielmo and Ndiop, Senegal, Revealed Using Genomic Surveillance[9]
  • Mapping the Malaria Parasite Druggable Genome by Using in vitro Evolution and Chemogenomics[10]
  • Modeling the genetic relatedness of Plasmodium falciparum Parasites Following Meiotic Recombination and Cotransmission[11]
  • Global Action for Training in Malaria Elimination[12]
  • malERA: An Updated Research Agenda for Basic Science and Enabling Technologies in Malaria Elimination and Eradication[13]
  • Genetic Diversity and Protective Efficacy of the RTS,S/AS01 Malaria Vaccine[14]
  • Modeling Malaria Genomics Reveals Transmission Decline and Rebound in Senegal[15]
  • COIL: A Methodology for Evaluating Malarial Complexity of Infection Using Likelihood from Single Nucleotide Polymorphism Data[16]
  • Sequence identification of cytochrome b in Plasmodium gallinaceum[17]

References

[edit]
  1. ^ "ASPPH | Harvard: Stephen Marks, Dyann Wirth Named AAAS Fellows". www.aspph.org. December 5, 2019. Retrieved 2021-11-24.{{cite web}}: CS1 maint: url-status (link)
  2. ^ a b c d Boston, 677 Huntington Avenue; Ma 02115 +1495‑1000. "Dyann Wirth's Faculty Website". Dyann Wirth's Faculty Website. Retrieved 2021-11-29.{{cite web}}: CS1 maint: numeric names: authors list (link)
  3. ^ Boston, 677 Huntington Avenue; Ma 02115 +1495‑1000 (2019-06-06). "New method to block malaria transmission identified". News. Retrieved 2021-11-29.{{cite web}}: CS1 maint: numeric names: authors list (link)
  4. ^ Boston, 677 Huntington Avenue; Ma 02115 +1495‑1000 (2021-10-08). "WHO's historic recommendation for malaria vaccine spurs hope". News. Retrieved 2021-11-29.{{cite web}}: CS1 maint: numeric names: authors list (link)
  5. ^ a b c d e f g h Boston, 677 Huntington Avenue; Ma 02115 +1495‑1000 (2015-05-08). "Honors and Awards". Dyann Wirth's Faculty Website. Retrieved 2021-11-29.{{cite web}}: CS1 maint: numeric names: authors list (link)
  6. ^ "ASTMH - Bailey K. Ashford Medal". www.astmh.org. Retrieved 2021-11-29.
  7. ^ Castro, Marcia C. (2017). "Malaria Transmission and Prospects for Malaria Eradication: The Role of the Environment". Cold Spring Harbor Perspectives in Medicine. 7 (10): a025601. doi:10.1101/cshperspect.a025601. ISSN 2157-1422. PMC 5629986. PMID 28490534.{{cite journal}}: CS1 maint: PMC format (link)
  8. ^ Early, Angela M.; Lievens, Marc; MacInnis, Bronwyn L.; Ockenhouse, Christian F.; Volkman, Sarah K.; Adjei, Samuel; Agbenyega, Tsiri; Ansong, Daniel; Gondi, Stacey; Greenwood, Brian; Hamel, Mary (2018-04-11). "Host-mediated selection impacts the diversity of Plasmodium falciparum antigens within infections". Nature Communications. 9 (1): 1381. doi:10.1038/s41467-018-03807-7. ISSN 2041-1723. PMC 5895824. PMID 29643376.{{cite journal}}: CS1 maint: PMC format (link)
  9. ^ Bei, Amy K; Niang, Makhtar; Deme, Awa B; Daniels, Rachel F; Sarr, Fatoumata D; Sokhna, Cheikh; Talla, Cheikh; Faye, Joseph; Diagne, Nafissatou; Doucoure, Souleymane; Mboup, Souleymane (2018-01-30). "Dramatic Changes in Malaria Population Genetic Complexity in Dielmo and Ndiop, Senegal, Revealed Using Genomic Surveillance". The Journal of Infectious Diseases. 217 (4): 622–627. doi:10.1093/infdis/jix580. ISSN 0022-1899. PMC 6279132. PMID 29325146.{{cite journal}}: CS1 maint: PMC format (link)
  10. ^ Cowell, Annie N.; Istvan, Eva S.; Lukens, Amanda K.; Gomez-Lorenzo, Maria G.; Vanaerschot, Manu; Sakata-Kato, Tomoyo; Flannery, Erika L.; Magistrado, Pamela; Owen, Edward; Abraham, Matthew; LaMonte, Gregory (2018-01-12). "Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics". Science. 359 (6372): 191–199. doi:10.1126/science.aan4472. PMC 5925756. PMID 29326268.{{cite journal}}: CS1 maint: PMC format (link)
  11. ^ Wong, Wesley; Wenger, Edward A.; Hartl, Daniel L.; Wirth, Dyann F. (2018-01-09). "Modeling the genetic relatedness of Plasmodium falciparum parasites following meiotic recombination and cotransmission". PLOS Computational Biology. 14 (1): e1005923. doi:10.1371/journal.pcbi.1005923. ISSN 1553-7358. PMC 5777656. PMID 29315306.{{cite journal}}: CS1 maint: PMC format (link) CS1 maint: unflagged free DOI (link)
  12. ^ Wirth, Dyann F.; Casamitjana, Núria; Tanner, Marcel; Reich, Michael R. (2018-01-25). "Global action for training in malaria elimination". Malaria Journal. 17 (1): 51. doi:10.1186/s12936-018-2199-3. ISSN 1475-2875. PMC 5785838. PMID 29370810.{{cite journal}}: CS1 maint: PMC format (link) CS1 maint: unflagged free DOI (link)
  13. ^ Technologies, The malERA Refresh Consultative Panel on Basic Science and Enabling (2017-11-30). "malERA: An updated research agenda for basic science and enabling technologies in malaria elimination and eradication". PLOS Medicine. 14 (11): e1002451. doi:10.1371/journal.pmed.1002451. ISSN 1549-1676. PMC 5708601. PMID 29190277.{{cite journal}}: CS1 maint: PMC format (link) CS1 maint: unflagged free DOI (link)
  14. ^ Neafsey, Daniel E.; Juraska, Michal; Bedford, Trevor; Benkeser, David; Valim, Clarissa; Griggs, Allison; Lievens, Marc; Abdulla, Salim; Adjei, Samuel; Agbenyega, Tsiri; Agnandji, Selidji T. (2015-11-19). "Genetic Diversity and Protective Efficacy of the RTS,S/AS01 Malaria Vaccine". New England Journal of Medicine. 373 (21): 2025–2037. doi:10.1056/NEJMoa1505819. ISSN 0028-4793. PMC 4762279. PMID 26488565.{{cite journal}}: CS1 maint: PMC format (link)
  15. ^ Daniels, Rachel F.; Schaffner, Stephen F.; Wenger, Edward A.; Proctor, Joshua L.; Chang, Hsiao-Han; Wong, Wesley; Baro, Nicholas; Ndiaye, Daouda; Fall, Fatou Ba; Ndiop, Medoune; Ba, Mady (2015-06-02). "Modeling malaria genomics reveals transmission decline and rebound in Senegal". Proceedings of the National Academy of Sciences. 112 (22): 7067–7072. doi:10.1073/pnas.1505691112. ISSN 0027-8424. PMC 4460456. PMID 25941365.{{cite journal}}: CS1 maint: PMC format (link)
  16. ^ Galinsky, Kevin; Valim, Clarissa; Salmier, Arielle; de Thoisy, Benoit; Musset, Lise; Legrand, Eric; Faust, Aubrey; Baniecki, Mary Lynn; Ndiaye, Daouda; Daniels, Rachel F.; Hartl, Daniel L. (2015-01-19). "COIL: a methodology for evaluating malarial complexity of infection using likelihood from single nucleotide polymorphism data". Malaria Journal. 14 (1): 4. doi:10.1186/1475-2875-14-4. ISSN 1475-2875. PMC 4417311. PMID 25599890.{{cite journal}}: CS1 maint: PMC format (link) CS1 maint: unflagged free DOI (link)
  17. ^ Aldritt, S M; Joseph, J T; Wirth, D F (1989). "Sequence identification of cytochrome b in Plasmodium gallinaceum". Molecular and Cellular Biology. 9 (9): 3614–3620. doi:10.1128/mcb.9.9.3614. ISSN 0270-7306. PMC 362421. PMID 2779560.{{cite journal}}: CS1 maint: PMC format (link)
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