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Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer occurring in about 3 person per 1,000,000 members of the population.[1] It is also known as cutaneous APUDoma, primary neuroendocrine carcinoma of the skin, primary small cell carcinoma of the skin, and trabecular carcinoma of the skin.[2] Factors involved in the development of MCC include the Merkel cell polyomavirus (MCPyV or MCV), a weakened immune system, and exposure to ultraviolet radiation.[3] Merkel-cell carcinoma usually arises on the head, neck, and extremities, as well as in the perianal region and eyelid.[4] It is more common in people over 60 years old, Caucasian people, and males[5]. MCC is less common in children.[1][4]
Signs and symptoms
[edit]![](http://upload.wikimedia.org/wikipedia/commons/thumb/d/db/Merkel_cell_carcinoma_arm.jpg/220px-Merkel_cell_carcinoma_arm.jpg)
![](http://upload.wikimedia.org/wikipedia/commons/thumb/b/b5/Merkel_Cell_Carcinoma_buttock_45-year-old_woman.jpg/220px-Merkel_Cell_Carcinoma_buttock_45-year-old_woman.jpg)
Merkel cell carcinoma (MCC) usually presents as a firm nodule (up to 2 cm diameter) or mass (>2 cm diameter). These flesh-colored, red, or blue tumors typically vary in size from 0.5 cm (less than one-quarter of an inch) to more than 5 cm (2 inches) in diameter and may enlarge rapidly. Tumors can present as painless, tender or itchy, and other MCC manifestations as papules or plaques have also been reported[6]. Although MCC may arise almost anywhere on the body, it is most commonly found in sun-exposed areas such as the head, neck or extremities[7]. Five key diagnostic attributes of MCC were summarized in 2008 with the acronym AEIOU (Asymptomatic/lack of tenderness, Expanding rapidly, Immune suppression, Older than 50 years, and Ultraviolet-exposed site on a person with fair skin).[8] Ninety percent of MCCs have 3 or more of those features.[9] MCC is sometimes mistaken in appearance for other skin cancers, including basal cell carcinoma, squamous cell carcinoma, malignant melanoma, cutaneous lymphoma or a benign cyst.[10] Merkel cell carcinomas have been described in children; however, pediatric cases are very rare.[11]
Merkel-cell cancers tend to invade locally, infiltrating the underlying subcutaneous fat, fascia, and muscle. They typically metastasize early in their natural history, most often to the regional lymph nodes. MCCs also spread aggressively through the blood vessels to many organs, particularly to liver, lung, brain, and bone.[12]
Pathophysiology
[edit]Cell of Origin
[edit]Although MCC was initially named for the Merkel cell due to histologic and physiologic similarities between MCC and Merkel cells, the cellular progenitor of MCC has been a heavily debated question. Merkel cells are highly specialized cells that act as pressure receptors in the epidermis. The origin of Merkel cells themselves is debated and proposed to be derived from neural crest cells or epidermal progenitors.[13] MCC is similar to Merkel cells in its histological appearance (see below: Diagnosis) and shares many immunohistochemical markers with Merkel cells, including epidermal marker cytokeratin 20 and neuroendocrine markers synaptophysin and chromogranin A. Furthermore, the ion channel Piezo2 and transcription factor Atoh1, both specific to Merkel cells, are also expressed by MCC.[14] However, Merkel cells are post-mitotic cells with a low probability of cancerous transformation[13]. Additionally, they have not been shown to support Merkel-cell polyoma virus infection, which is believed to drive oncogenesis in approximately 80% of MCC[15].
Instead, it has been proposed the MCC may originate from a Merkel cell precursor, at which point it gains features similar to those of Merkel cells. One such precursor is the human fibroblast. Evidence for a fibroblast precursor includes its location in the dermis, which is thought to be the primary site of origin for MCC. Additionally, in vitro experiments have demonstrated that fibroblasts not only support MCV infection but can be induced into having a MCC phenotype by the expression of viral proteins [15][16].
However, others have argued that MCC likely derives from an epithelial precursor cell due to its frequent presence in mixed tumors including epithelial neoplasms such as squamous cell carcinoma. While epithelial cells are not typically found in the dermis, hair follicles include epithelial cells that have been shown to have oncogenic potential, and have therefore been proposed as a possible site for a MCC precursor[17][3].
Finally, the presence of B-cell surface markers on MCC in addition to the high correlation between MCC and B-cell lymphomatous cancers have also led to suggestions that MCC may share a progenitor with B-cells [14][18]. Because of the differences in physiology and prognosis between MCV+ and MCV- MCC (see below), however, some have suggested that these two subtypes of MCC may actually derive from different progenitor cells[19].
Merkel cell polyoma virus
[edit]The MCV is a small double-stranded DNA virus that is believed to contribute to the development of the majority of MCC[20]. About 80% of MCC tumors are infected with MCV, with the virus integrated into the host genome in a monoclonal pattern[20]. However, the majority of people with MCV infection do not develop MCC: MCV is a ubiquitous virus and infection commonly occurs during childhood but remains asymptomatic throughout an individual’s lifetime[16].
MCC was first believed to be associated with MCV when it was observed to occur at a much higher rate in HIV patients during the 1980s [21]. Since then, studies have demonstrated integration of the MCV genome into the genome of MCC tumor cells. Central to the our understanding of the pathogenicity of MCV are two viral proteins expressed in infected cells known as the large tumor antigen (LT) and small tumor antigen (sT)[22]. Normally, patients infected with MCV show low levels of antibodies to the LT protein, perhaps due to a nuclear localization domain in its C-terminal that limits its cellular dispersion. However, integration of the viral genome into the host genome can result in truncation of the LT protein proximal to this domain. This serves two oncogenic purposes: first, it prevents successful viral replication that would culminate in lysis of the infected cell. Second, it redistributes the LT protein to the cytoplasm, where it can interact with cytoplasmic signaling[23]. The N-terminal LXCXE motif of the LT protein has been shown to interact with known oncogene Rb and is conserved in other cancer-causing viruses[23]. Studies suggest that LT may also preserve cell proliferation signals such as c-Myc and cyclin E and cause DNA injury to the p53 tumor suppressor[15][16].
Meanwhile, sT has been shown to induce cell proliferation through hyper-phosphorylation of the translation initiator 4EBP1 as well as inhibition of a ubiquitin ligase complex responsible for degradation of cellular proliferation signals. sT also contains a region known as the LT stabilization domain (LSD), which potentiates the LT protein's oncogenic function. Unlike LT, MCC samples have been identified that express sT alone, and sT expression in fibroblasts has been shown to cause MCC phenotype development[15][16].
UV Light
[edit]About 20% of MCC tumors are MCV negative[7]. In contrast to MCV-induced MCC, these tumors tend to have much higher mutational burdens with mutational signatures characteristic of UV damage[15]. Genes frequently mutated in MCV-negative MCC include p53 and Rb, among others[22]. The link between MCC and UV exposure has been demonstrated through various epidemiological studies indicating a higher incidence of MCC in fair-skinned people in areas of high UV exposure, as well as among those receiving UV phototherapy[6]. The typical distribution of MCC in sun exposed regions and its co-occurrence with other skin cancers also indicate that UV exposure is a contributing factor to MCC development. It is unclear whether this is through direct mutational impact, immune down-regulation, or some combination of the two[6][24].
Immunosuppression
[edit]The incidence of MCC is increased in conditions with defective immune functions such as malignancy, HIV infection, and organ transplant patients, etc[25]. Conversely, patients with brisk immune response have been shown to have improved prognoses[26]. This is suspected to be due to the inability of the body to defend itself from infection by or reactivation of MVC[27]. The body of data indicating the importance of immune function in MCC pathogenesis has been exploited for the development of immunotherapies discussed below.
Diagnosis
[edit]![](http://upload.wikimedia.org/wikipedia/commons/thumb/3/3f/Micrographs_of_a_typical_merkel_cell_carcinoma.jpg/260px-Micrographs_of_a_typical_merkel_cell_carcinoma.jpg)
Diagnosis of MCC begins with a clinical examination of the skin and lymph nodes.[29] Following clinical examination, definitive diagnosis of Merkel cell carcinoma (MCC) requires examination of biopsy tissue to identify its histopathologic features.[29][30] An ideal biopsy specimen is either a punch biopsy or a full-thickness incisional biopsy of the skin including full-thickness dermis and subcutaneous fat. On light microscopy, MCC shows basaloid tumor nests with neuroendocrine features ("salt and pepper" chromatin, scarce cytoplasm, and brisk mitotic activity).[29][30] In addition to standard examination under light microscopy, immunohistochemistry (IHC) is also generally required to differentiate MCC from other small blue cell tumors such as small cell lung cancer, the small cell variant of melanoma, various cutaneous leukemic/lymphoid neoplasms, and Ewing's sarcoma. Neuroendocrine molecular markers such as synaptophysin or chromogranin A are characteristic of MCC and other neuroendocrine tumors, while other markers such as PAX5 or cytokeratin 20 can distinguish MCC from these tumors[3][7]. Longitudinal imaging may also help in ruling out a diagnosis of metastatic small cell lung cancer. Once an MCC diagnosis is made, a sentinel lymph node biopsy as well as other imaging is recommended as a part of the staging work-up needed to determine prognosis and subsequent treatment options. [29][30]
Prevention
[edit]Sunlight exposure is suspected to contribute to the development of Merkel cell carcinoma (MCC), as discussed above (see: Pathophysiology). The World Health Organization, American Academy of Dermatology, and Skin Cancer Foundation recommend the following measures to prevent excessive UV exposure and skin cancer:[31][32][33]
- Limiting sun exposure between the hours of 10am and 4pm, when UV rays are the strongest
- Seeking shade when UV rays are most intense
- Wearing sun-protective clothing including a wide brim hat, sunglasses, and tightly-woven, loose-fitting clothing
- Using sunscreen
- Avoiding tanning beds and artificial UV exposure
Preventative vaccines similar to those developed for HPV have been proposed in the past, but this method of prevention has generally been deemed prohibitively expensive given the rarity of MCC[23].
Therapy
[edit]Surgery
[edit]The primary approach to MCC treatment is surgical excision, with the goal of removing the entire lesion with negative resection margins. Complete excision is associated with significantly higher survival rates. Surgical margins should extend 1 to 2 cm beyond the border of the MCC and may include underlaying fascia and muscle if the MCC has invaded deeper than the dermis[34]. If the MCC lesion is located in an unfavorable location (e.g. the face), MOHS surgery may be preferable in order to ensure complete excision while sparing the maximal area possible[35]. Surgical excision should be coordinated with the sentinel lymph node biopsy (SNLB) in order to rule out metastasis[34]. Reconstruction may be needed if the surgical treatment requires extensive tissue removal; however, reconstruction should not occur until negative margins and a negative SLNB have been confirmed[36].
Radiation
[edit]Surgical excision followed by radiotherapy has historically been the primary modes of MCC treatment[26]. MCC has been shown to be very responsive to radiotherapy; however, the utility of radiotherapy is controversial. There is some evidence that radiotherapy can assist in controlling disease spread. For this reason, adjuvant radiotherapy is part of the current American guidelines[37]. However, some studies have suggested that radiotherapy has little success in improving long-term outcomes, leading to suggestions that radiotherapy be used primarily in palliative cases or cases where surgery is contraindicated[7][34].
Chemotherapy
[edit]Because of its significant adverse effects, traditional chemotherapy has been saved for late-stage highly metastasized cases of MCC. While some chemotherapeutic regiments have been shown to have transient effects, studies have not found any significant long-term effect on recurrence rate or life expectancy[15]. As of 2015, there were no FDA-approved standard chemotherapy regimens for MCC treatment[26]. The most recent American guidelines do not recommend adjuvant chemotherapy, citing a lack of evidence to suggest improved outcomes. Instead, consideration of the need for chemotherapy on a case-by-case basis is recommended[37].
Immunotherapy
[edit]Immunotherapies, namely inhibitors of the PD1-PDL1 checkpoint signaling pathway, are novel anticancer agents that have shown benefit in advanced-stage MCC or chemotherapy-resistant MCC.[35][26] The PD-1 pathway is responsible for regulating the balance between T-cell activation and over-activation leading to T-cell exhaustion or autoimmunity[38]. However, over-expression of PD-1 ligands (PDL1) have been observed in tumors as a method of evading immune attack[39]. PD-1 inhibition therefore enhances the body's immune response, enabling it to target cancer cells for destruction.[40] Due to their side effects, however, National Comprehensive Cancer Network guidelines recommend PD-1 inhibitors for people with disseminated rather than early-stage MCC.[41]
PD1/PDL1 pathway inhibitors approved or in clinical trials for use in MCC treatment include:
- In March 2017, the U.S. Food and Drug Administration granted accelerated approval to Avelumab, a PDL1 inhibitor, to treat adults and children above 12 years with metastatic MCC.[42]
- In December 2018, the U.S. Food and Drug Administration granted accelerated approval to Pembrolizumab (KEYTRUDA®, Merck & Co. Inc.) for all ages (adults and pediatrics) with recurrent locally advanced or metastatic Merkel cell carcinoma[43]
- Nivolumab (brand name Opdivo, Bristol-Myers Squibb) is in phase III/IV clinical trials[22][44]
- Ipilimumab (brand name Yervoy, Bristol-Myers Squibb) is in phase II clinical trials for use in adults with metastatic MCC. [45][44]
Studies to date have shown a clinical response rate between 50-65% for MCC treated with PD-1 pathway inhibitors. Suggestions for further immunotherapy research areas have included therapeutic vaccines or epigenetic modification of HLA-receptors. [22][23][26][35]
Prognosis
[edit]According to the American Joint Committee on Cancer (AJCC), the natural course of MCC is “variable and depends heavily on the stage at diagnosis".[46] Staging of MCC is classified according to the TNM staging system, a notation system that describes the stage of cancer according to the size of the primary tumor (T), the degree of spread to regional lymph nodes (N), and the presence of distant metastasis (M).[46] A combination of T, N, and M stages dictate the final clinical stage group (0, I, IIA, IIB, IIIA, IIIB, IV).[47] Advanced stage (i.e. increased size of the tumor, spreading of the tumor into surrounding and/or distant tissue, and involvement of lymph nodes) is associated with lower survival rates.[7]
The National Cancer Data Base has survival rates collected from nearly 3000 MCC patients from year 1996–2000 with 5-year survival rates listed as follows:[48] Stage IA: 80%. Stage IB: 60%. Stage IIA: 60%. Stage IIB: 50%. Stage IIC: 50%. Stage IIIA: 45%. Stage IIIB: 25%. Stage IV: 20%. 5 yr survival may be 51% among people with localized disease, 35% for those with nodal disease, and 14% with metastases to a distant site.[49]
Several other features may also affect prognosis independent of tumor stage. They include MCV viral status, histological features, and immune status. Regarding viral status, MCV large tumor antigen (LT antigen) and retinoblastoma protein (RB protein) expression correlate with more favorable prognosis, while p63 expression correlates with a poorer prognosis.[50][51] Histological features such as intratumoral CD8+ T lymphocyte infiltration may be associated with a favorable prognosis, while lymphovascular infiltrative pattern may be associated with a poorer prognosis.[52][53] Immune status, especially T cell immunosuppression (e.g., organ transplant, HIV infection, certain malignancy) predicts poorer prognosis and higher mortality.[54]
The antibody titer in the blood to the Merkel cell polyomavirus oncoprotein can be used as a treatment response biomarker in people that have detectable antibodies at the time of diagnosis.[55][56]
Epidemiology
[edit]Merkel cell carcinoma occurs most often in Caucasians between 60 and 80 years of age. Its incidence is about twice as high in males as in females[57]. It is a rare type of skin cancer, with a 2013 incidence of only 0.7 per 100,000 persons in the U.S.[58] As of 2005, roughly 2,500 new cases of MCC are diagnosed each year in the United States,[58] as compared to around 60,000 new cases of malignant melanoma and over 1 million new cases of nonmelanoma skin cancer.[59] Similar to melanoma, the incidence of MCC in the US is increasing rapidly.[60] Worldwide, MCC is most commonly found in regions with increased sun exposure. Australia is the country with the highest incidence of MCC[57] but has a lower incidence of MCV-positive MCC than observed in other countries. [61]
Since 2006, it has been known that other primary cancers increase the risk of MCC significantly, especially in those with the prior multiple myeloma, chronic lymphocytic leukemia, and malignant melanoma.[62] Immunosuppression including HIV infection or immunosuppressant therapy following organ transplant or for autoimmune disease can also increase the odds of developing MCC.[63]
History
[edit]Friedrich Sigmund Merkel (1845-1919) was a German anatomist and histopathologist who first described the Tastzellen (touch cells) in the skin in 1875.[64] In 1878 the term Merkel cell was coined by the anatomist Robert Bonnet (1851–1921).
Merkel-cell carcinoma was first described in 1972 by Cyril Toker.[65] He reported five cases of 'trabecular carcinoma of the skin'.
Famous individuals afflicted
[edit]- Avigdor Arikha – Paris-based painter and art historian
- David Brudnoy – Boston talk radio host
- Al Copeland – New Orleans entrepreneur, powerboat racer
- Al Davis – Principal owner of the Oakland Raiders of the National Football League
- Ed Derwinski – U.S. Representative from Illinois and 1st Secretary of Veterans Affairs
- Leonard Hirshan – Showbusiness agent and manager.
- Max Perutz – Nobel Prize–winning chemist
- Lindsay Thompson – Former Premier of Victoria, Australia
- Joe Zawinul – Jazz-fusion keyboardist and composer[66]
- John Fitch – Race car driver and road safety pioneer
- Carl Mundy – 30th Commandant of the United States Marine Corps
- Geoffrey Penwill Parsons – Pianist
- Maria Bueno - Tennis player[67]
References
[edit]- ^ a b "Merkel-cell carcinima". Dynamed. Retrieved 2019-11-11.
{{cite web}}
: CS1 maint: url-status (link) - ^ Dermatology. Bolognia, Jean., Jorizzo, Joseph L., Rapini, Ronald P. (2nd ed.). St. Louis, MO: Mosby/Elsevier. 2008. ISBN 978-1-4160-2999-1. OCLC 212399895.
{{cite book}}
: CS1 maint: others (link) - ^ a b c Kervarrec, Thibault; Samimi, Mahtab; Guyétant, Serge; Sarma, Bhavishya; Chéret, Jérémy; Blanchard, Emmanuelle; Berthon, Patricia; Schrama, David; Houben, Roland; Touzé, Antoine (10 June 2019). "Histogenesis of Merkel Cell Carcinoma: A Comprehensive Review". Frontiers in Oncology. 9. doi:10.3389/fonc.2019.00451. PMC 6579919. PMID 31245285.
{{cite journal}}
: CS1 maint: unflagged free DOI (link) - ^ a b Patterson, James W. (James Willis), 1946- (2014-12-07). Weedon's skin pathology. Hosler, Gregory A. (Fourth ed.). [Edinburgh?]. ISBN 978-0-7020-6200-1. OCLC 900724639.
{{cite book}}
: CS1 maint: location missing publisher (link) CS1 maint: multiple names: authors list (link) CS1 maint: numeric names: authors list (link) - ^ Pulitzer, Melissa (2017-06). "Merkel Cell Carcinoma". Surgical Pathology Clinics. 10 (2): 399–408. doi:10.1016/j.path.2017.01.013. PMC 5443625. PMID 28477888.
{{cite journal}}
: Check date values in:|date=
(help)CS1 maint: PMC format (link) - ^ a b c Coggshall, Kathleen; Tello, Tiffany L.; North, Jeffrey P.; Yu, Siegrid S. (2018-03). "Merkel cell carcinoma: An update and review". Journal of the American Academy of Dermatology. 78 (3): 433–442. doi:10.1016/j.jaad.2017.12.001. ISSN 0190-9622.
{{cite journal}}
: Check date values in:|date=
(help) - ^ a b c d e Emge, Drew A.; Cardones, Adela R. (2019-10). "Updates on Merkel Cell Carcinoma". Dermatologic Clinics. 37 (4): 489–503. doi:10.1016/j.det.2019.06.002. ISSN 0733-8635.
{{cite journal}}
: Check date values in:|date=
(help) - ^ Heath M, Jaimes N, Lemos B, Mostaghimi A, Wang LC, Peñas PF, Nghiem P (March 2008). "Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features". Journal of the American Academy of Dermatology. 58 (3): 375–81. doi:10.1016/j.jaad.2007.11.020. PMC 2335370. PMID 18280333.
- ^ Voelker, Rebecca (3 July 2018). "Why Merkel Cell Cancer Is Garnering More Attention". JAMA. 320 (1): 18. doi:10.1001/jama.2018.7042. PMID 29898204.
- ^ Schrama D, Ugurel S, Becker JC (March 2012). "Merkel cell carcinoma: recent insights and new treatment options". Current Opinion in Oncology. 24 (2): 141–9. doi:10.1097/CCO.0b013e32834fc9fe. PMID 22234254.
- ^ Paulson KG, Nghiem P (June 2019). "One in a hundred million: Merkel cell carcinoma in pediatric and young adult patients is rare but more likely to present at advanced stages based on US registry data". Journal of the American Academy of Dermatology. 80 (6): 1758–1760. doi:10.1016/j.jaad.2018.08.021. PMC 6487227. PMID 30165170.
- ^ "Merkel Cell Carcinoma Treatment". National Cancer Institute. 2006-02-21. Retrieved 2018-03-04.
- ^ a b Cook, Deborah L.; Frieling, Gretchen W. (2016-04). "Merkel cell carcinoma: a review and update on current concepts". Diagnostic Histopathology. 22 (4): 127–133. doi:10.1016/j.mpdhp.2016.04.002. ISSN 1756-2317.
{{cite journal}}
: Check date values in:|date=
(help) - ^ a b Kervarrec, Thibault; Samimi, Mahtab; Guyétant, Serge; Sarma, Bhavishya; Chéret, Jérémy; Blanchard, Emmanuelle; Berthon, Patricia; Schrama, David; Houben, Roland; Touzé, Antoine (2019-06-10). "Histogenesis of Merkel Cell Carcinoma: A Comprehensive Review". Frontiers in Oncology. 9: 451. doi:10.3389/fonc.2019.00451. ISSN 2234-943X. PMC 6579919. PMID 31245285.
{{cite journal}}
: CS1 maint: PMC format (link) CS1 maint: unflagged free DOI (link) - ^ a b c d e f MacDonald, Margo; You, Jianxin (2017), "Merkel Cell Polyomavirus: A New DNA Virus Associated with Human Cancer", Advances in Experimental Medicine and Biology, Springer Singapore, pp. 35–56, ISBN 978-981-10-5764-9, retrieved 2020-05-11
- ^ a b c d DeCaprio, James A. (2017-10-19). "Merkel cell polyomavirus and Merkel cell carcinoma". Philosophical Transactions of the Royal Society B: Biological Sciences. 372 (1732): 20160276. doi:10.1098/rstb.2016.0276. ISSN 0962-8436. PMC 5597743. PMID 28893943.
{{cite journal}}
: CS1 maint: PMC format (link) - ^ Walsh, Noreen M.G. (2001-07). "Primary neuroendocrine (Merkel cell) carcinoma of the skin: Morphologic diversity and implications thereof". Human Pathology. 32 (7): 680–689. doi:10.1053/hupa.2001.25904.
{{cite journal}}
: Check date values in:|date=
(help) - ^ Tadmor, T.; Aviv, A.; Polliack, A. (2011-02). "Merkel cell carcinoma, chronic lymphocytic leukemia and other lymphoproliferative disorders: an old bond with possible new viral ties". Annals of Oncology. 22 (2): 250–256. doi:10.1093/annonc/mdq308. ISSN 0923-7534.
{{cite journal}}
: Check date values in:|date=
(help) - ^ Sunshine, J. C.; Jahchan, N. S.; Sage, J.; Choi, J. (2018-03). "Are there multiple cells of origin of Merkel cell carcinoma?". Oncogene. 37 (11): 1409–1416. doi:10.1038/s41388-017-0073-3. ISSN 0950-9232.
{{cite journal}}
: Check date values in:|date=
(help) - ^ a b Amber, Kyle; McLeod, Michael P.; Nouri, Keyvan (2013-02). "The Merkel Cell Polyomavirus and Its Involvement in Merkel Cell Carcinoma:". Dermatologic Surgery. 39 (2): 232–238. doi:10.1111/dsu.12079. ISSN 1076-0512.
{{cite journal}}
: Check date values in:|date=
(help) - ^ Engels, Eric A; Frisch, Morten; Goedert, James J; Biggar, Robert J; Miller, Robert W (2002-02). "Merkel cell carcinoma and HIV infection". The Lancet. 359 (9305): 497–498. doi:10.1016/S0140-6736(02)07668-7.
{{cite journal}}
: Check date values in:|date=
(help) - ^ a b c d Becker, Jürgen C.; Stang, Andreas; Hausen, Axel zur; Fischer, Nicole; DeCaprio, James A.; Tothill, Richard W.; Lyngaa, Rikke; Hansen, Ulla Kring; Ritter, Cathrin; Nghiem, Paul; Bichakjian, Christopher K. (2018-03). "Epidemiology, biology and therapy of Merkel cell carcinoma: conclusions from the EU project IMMOMEC". Cancer Immunology, Immunotherapy. 67 (3): 341–351. doi:10.1007/s00262-017-2099-3. ISSN 0340-7004. PMC 6015651. PMID 29188306.
{{cite journal}}
: Check date values in:|date=
(help)CS1 maint: PMC format (link) - ^ a b c d Tabachnick-Cherny, Shira; Pulliam, Thomas; Church, Candice; Koelle, David M.; Nghiem, Paul (2020-03-27). "Polyomavirus-driven Merkel cell carcinoma: Prospects for therapeutic vaccine development". Molecular Carcinogenesis. doi:10.1002/mc.23190.
- ^ Schrama, David; Ugurel, Selma; Becker, Jürgen C. (2012-03). "Merkel cell carcinoma: recent insights and new treatment options". Current Opinion in Oncology. 24 (2): 141–149. doi:10.1097/CCO.0b013e32834fc9fe. ISSN 1040-8746.
{{cite journal}}
: Check date values in:|date=
(help) - ^ Tello, Tiffany L.; Coggshall, Kathleen; Yom, Sue S.; Yu, Siegrid S. (2018-03). "Merkel cell carcinoma: An update and review". Journal of the American Academy of Dermatology. 78 (3): 445–454. doi:10.1016/j.jaad.2017.12.004. ISSN 0190-9622.
{{cite journal}}
: Check date values in:|date=
(help) - ^ a b c d e Harms, Paul W.; Harms, Kelly L.; Moore, Patrick S.; DeCaprio, James A.; Nghiem, Paul; Wong, Michael K. K.; Brownell, Isaac; International Workshop on Merkel Cell Carcinoma Research (IWMCC) Working, Group. (4 October 2018). "The biology and treatment of Merkel cell carcinoma: current understanding and research priorities". Nature Reviews Clinical Oncology. 15 (12): 763–776. doi:10.1038/s41571-018-0103-2. PMC 6319370. PMID 30287935.
- ^ de Visser, Karin E.; Eichten, Alexandra; Coussens, Lisa M. (2006-01). "Paradoxical roles of the immune system during cancer development". Nature Reviews Cancer. 6 (1): 24–37. doi:10.1038/nrc1782. ISSN 1474-175X.
{{cite journal}}
: Check date values in:|date=
(help) - ^ Originally copied from: Nguyen AH, Tahseen AI, Vaudreuil AM, Caponetti GC, Huerter CJ (2017). "Clinical features and treatment of vulvar Merkel cell carcinoma: a systematic review". Gynecologic Oncology Research and Practice. 4 (1): 2. doi:10.1186/s40661-017-0037-x. PMC 5264489. PMID 28138393.
{{cite journal}}
: CS1 maint: unflagged free DOI (link) - "Fig 2- available via license: Creative Commons Attribution 4.0 International" - ^ a b c d Amaral, Teresa; Leiter, Ulrike; Garbe, Claus (16 September 2017). "Merkel cell carcinoma: Epidemiology, pathogenesis, diagnosis and therapy". Reviews in Endocrine and Metabolic Disorders. 18 (4): 517–532. doi:10.1007/s11154-017-9433-0. PMID 28916903.
- ^ a b c Coggshall, Kathleen; Tello, Tiffany L.; North, Jeffrey P.; Yu, Siegrid S. (March 2018). "Merkel cell carcinoma: An update and review". Journal of the American Academy of Dermatology. 78 (3): 433–442. doi:10.1016/j.jaad.2017.12.001. PMID 29229574.
- ^ "Sun protection". World Health Organization. Retrieved 2018-03-28.
- ^ "Prevention Guidelines - SkinCancer.org". www.skincancer.org. Retrieved 2018-03-28.
- ^ "Prevent skin cancer | American Academy of Dermatology". www.aad.org. Retrieved 2018-03-28.
- ^ a b c Lebbe, Celeste; Becker, Jürgen C.; Grob, Jean-Jacques; Malvehy, Josep; del Marmol, Veronique; Pehamberger, Hubert; Peris, Ketty; Saiag, Philippe; Middleton, Mark R.; Bastholt, Lars; Testori, Alessandro (2015-11). "Diagnosis and treatment of Merkel Cell Carcinoma. European consensus-based interdisciplinary guideline". European Journal of Cancer. 51 (16): 2396–2403. doi:10.1016/j.ejca.2015.06.131. ISSN 0959-8049.
{{cite journal}}
: Check date values in:|date=
(help) - ^ a b c Becker, Jürgen C.; Stang, Andreas; DeCaprio, James A.; Cerroni, Lorenzo; Lebbé, Celeste; Veness, Michael; Nghiem, Paul (26 October 2017). "Merkel cell carcinoma". Nature Reviews Disease Primers. 3 (1). doi:10.1038/nrdp.2017.77. PMC 6054450. PMID 29072302.
- ^ Bichakjian, Christopher K.; Olencki, Thomas; Aasi, Sumaira Z.; Alam, Murad; Andersen, James S.; Blitzblau, Rachel; Bowen, Glen M.; Contreras, Carlo M.; Daniels, Gregory A.; Decker, Roy; Farma, Jeffrey M. (2018-06-01). "Merkel Cell Carcinoma, Version 1.2018, NCCN Clinical Practice Guidelines in Oncology". Journal of the National Comprehensive Cancer Network. 16 (6): 742–774. doi:10.6004/jnccn.2018.0055. ISSN 1540-1405.
- ^ a b Yu, Siegrid (2019-11-19). "Faculty Opinions recommendation of Merkel cell carcinoma, version 1.2018, NCCN clinical practice guidelines in oncology". Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature. Retrieved 2020-05-12.
- ^ Sharpe, Arlene H.; Pauken, Kristen E. (2017-11-13). "The diverse functions of the PD1 inhibitory pathway". Nature Reviews Immunology. 18 (3): 153–167. doi:10.1038/nri.2017.108. ISSN 1474-1733.
- ^ LaFleur, Martin W.; Muroyama, Yuki; Drake, Charles G.; Sharpe, Arlene H. (2018-01-15). "Inhibitors of the PD-1 Pathway in Tumor Therapy". The Journal of Immunology. 200 (2): 375–383. doi:10.4049/jimmunol.1701044. ISSN 0022-1767. PMC 5924692. PMID 29311378.
{{cite journal}}
: CS1 maint: PMC format (link) - ^ Topalian, Suzanne L.; Drake, Charles G.; Pardoll, Drew M. (April 2015). "Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy". Cancer Cell. 27 (4): 450–461. doi:10.1016/j.ccell.2015.03.001. PMC 4400238. PMID 25858804.
- ^ Voelker, Rebecca (3 July 2018). "Why Merkel Cell Cancer Is Garnering More Attention". JAMA. 320 (1): 18. doi:10.1001/jama.2018.7042. PMID 29898204.
- ^ FDA approves first treatment for rare form of skin cancer FDA News Release, March 23, 2017
- ^ [1] Archived 2013-08-19 at the Wayback Machine FDA News Release, December 19, 2018
- ^ a b "Immunotherapy for Merkel Cell Carcinoma | Merkel Cell Carcinoma". Retrieved 2020-05-14.
- ^ "Study of the Drug Ipilimumab for Metastatic Merkel Cell Carcinoma - Full Text View - ClinicalTrials.gov". clinicaltrials.gov. Retrieved 2020-05-14.
- ^ a b AJCC cancer staging manual. Amin, Mahul B.,, Edge, Stephen B.,, American Joint Committee on Cancer (Eighth ed.). Switzerland. 2018-03-30. ISBN 978-3-319-40617-6. OCLC 961218414.
{{cite book}}
: CS1 maint: location missing publisher (link) CS1 maint: others (link) - ^ "PDQ (Physician Data Query)". JNCI Journal of the National Cancer Institute. 105 (21): 1592–1593. 18 October 2013. doi:10.1093/jnci/djt327.
- ^ "Survival Rates for Merkel Cell Carcinoma, by Stage". www.cancer.org. Retrieved 2018-03-03.
- ^ Voelker, Rebecca (3 July 2018). "Why Merkel Cell Cancer Is Garnering More Attention". JAMA. 320 (1): 18. doi:10.1001/jama.2018.7042. PMID 29898204.
- ^ Sihto H, Kukko H, Koljonen V, Sankila R, Böhling T, Joensuu H (July 2011). "Merkel cell polyomavirus infection, large T antigen, retinoblastoma protein and outcome in Merkel cell carcinoma". Clinical Cancer Research. 17 (14): 4806–13. doi:10.1158/1078-0432.CCR-10-3363. PMID 21642382.
- ^ Stetsenko GY, Malekirad J, Paulson KG, Iyer JG, Thibodeau RM, Nagase K, et al. (December 2013). "p63 expression in Merkel cell carcinoma predicts poorer survival yet may have limited clinical utility". American Journal of Clinical Pathology. 140 (6): 838–44. doi:10.1309/AJCPE4PK6CTBNQJY. PMC 4074520. PMID 24225752.
- ^ Paulson KG, Iyer JG, Tegeder AR, Thibodeau R, Schelter J, Koba S, et al. (April 2011). "Transcriptome-wide studies of merkel cell carcinoma and validation of intratumoral CD8+ lymphocyte invasion as an independent predictor of survival". Journal of Clinical Oncology. 29 (12): 1539–46. doi:10.1200/JCO.2010.30.6308. PMC 3082974. PMID 21422430.
- ^ Andea AA, Coit DG, Amin B, Busam KJ (November 2008). "Merkel cell carcinoma: histologic features and prognosis". Cancer. 113 (9): 2549–58. doi:10.1002/cncr.23874. PMID 18798233.
- ^ Asgari MM, Sokil MM, Warton EM, Iyer J, Paulson KG, Nghiem P (July 2014). "Effect of host, tumor, diagnostic, and treatment variables on outcomes in a large cohort with Merkel cell carcinoma". JAMA Dermatology. 150 (7): 716–23. doi:10.1001/jamadermatol.2013.8116. PMC 4141075. PMID 24807619.
- ^ Paulson KG, Bhatia S (June 2018). "Advances in Immunotherapy for Metastatic Merkel Cell Carcinoma: A Clinician's Guide". Journal of the National Comprehensive Cancer Network. 16 (6): 782–790. doi:10.6004/jnccn.2018.7049. PMID 29891528.
- ^ Paulson KG, Lewis CW, Redman MW, Simonson WT, Lisberg A, Ritter D, et al. (April 2017). "Viral oncoprotein antibodies as a marker for recurrence of Merkel cell carcinoma: A prospective validation study". Cancer. 123 (8): 1464–1474. doi:10.1002/cncr.30475. PMC 5384867. PMID 27925665.
- ^ a b Schadendorf, Dirk; Lebbé, Céleste; zur Hausen, Axel; Avril, Marie-Françoise; Hariharan, Subramanian; Bharmal, Murtuza; Becker, Jürgen C. (2017-01). "Merkel cell carcinoma: Epidemiology, prognosis, therapy and unmet medical needs". European Journal of Cancer. 71: 53–69. doi:10.1016/j.ejca.2016.10.022. ISSN 0959-8049.
{{cite journal}}
: Check date values in:|date=
(help) - ^ a b Paulson KG, Park SY, Vandeven NA, Lachance K, Thomas H, Chapuis AG, et al. (March 2018). "Merkel cell carcinoma: Current US incidence and projected increases based on changing demographics". Journal of the American Academy of Dermatology. 78 (3): 457–463.e2. doi:10.1016/j.jaad.2017.10.028. PMC 5815902. PMID 29102486.
- ^ Hodgson NC (January 2005). "Merkel cell carcinoma: changing incidence trends". Journal of Surgical Oncology. 89 (1): 1–4. doi:10.1002/jso.20167. PMID 15611998.
- ^ Schrama D, Ugurel S, Becker JC (March 2012). "Merkel cell carcinoma: recent insights and new treatment options". Current Opinion in Oncology. 24 (2): 141–9. doi:10.1097/CCO.0b013e32834fc9fe. PMID 22234254.
- ^ "Merkel cell polyomavirus is more frequently present in North American than Australian Merkel cell carcinoma tumors". Retrieved 2020-05-14.
- ^ Howard RA, Dores GM, Curtis RE, Anderson WF, Travis LB (August 2006). "Merkel cell carcinoma and multiple primary cancers". Cancer Epidemiology, Biomarkers & Prevention. 15 (8): 1545–9. doi:10.1158/1055-9965.EPI-05-0895. PMID 16896047.
- ^ Rotondo, John Charles; Bononi, Ilaria; Puozzo, Andrea; Govoni, Marcello; Foschi, Valentina; Lanza, Giovanni; Gafà, Roberta; Gaboriaud, Pauline; Touzé, Françoise Antoine; Selvatici, Rita; Martini, Fernanda; Tognon, Mauro (15 July 2017). "Merkel Cell Carcinomas Arising in Autoimmune Disease Affected Patients Treated with Biologic Drugs, Including Anti-TNF". Clinical Cancer Research. 23 (14): 3929–3934. doi:10.1158/1078-0432.CCR-16-2899. PMID 28174236.
- ^ Merkel, F (1875). "Tastzellen und Tastkörperchen bei den Hausthieren und beim Menschen" [Probe cells and probe bodies in domestic animals and in humans]. Archiv für mikroskopische Anatomie (in German). 11 (1): 636–652. doi:10.1007/BF02933819.
- ^ Toker, Cyril (January 1972). "Trabecular carcinoma of the skin". Archives of Dermatology. 105 (1): 107–110. doi:10.1001/archderm.1972.01620040075020. PMID 5009611.
- ^ Keepnews, Peter (12 September 2007). "Joe Zawinul, 75, Jazz Fusion Pioneer, Dies". The New York Times.
- ^ Obituaries, The Daily Telegraph, London, UK, 11 June 2018, pg27