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UK Biobank
UK Biobank Co-ordinating and Assessment Centre
Mission statement"Improving the prevention, diagnosis and treatment of a wide range of serious and life-threatening illnesses – including cancer, heart diseases, stroke, diabetes, arthritis, osteoporosis, eye disorders, depression and forms of dementia."
Commercial?No
LocationStockport, Greater Manchester, UK
FounderRory Collins
Established2002 (2002)
Websitewww.ukbiobank.ac.uk

UK Biobank is a long-term prospective biobank study in the United Kingdom (UK)[1] that houses de-identified[2] biological samples and health-related data[3] on half a million people. Volunteer participants aged 40-69 were recruited between 2006-2010[1] from across Great Britain and consented to share their health data and to be followed for at least 30 years thereafter with the aim to enable scientific discoveries into the prevention, diagnosis, and treatment[3] of disease.

UK Biobank holds more than 10,000 variables of data on many of their 500,000 participants to inform research including biological samples, physical measurements, body and brain imaging data, bone density data, activity tracking and lifestyle questionnaire data.[3][4] Participants continue to provide more data over time. They have over 15 million biological samples stored, which can be requested for use by researchers, and their online database holds over 30 petabytes of data.[5][6][7] Their human genome sequencing database, proteomic database, and human imaging project are the largest in the world.[8][9] The project is enabling scientists to study the onset of diseases such as cancers, heart disease, and age-related conditions in the early stages of their development.[10][11][12] Nature has referred to UK Biobank as an "unprecedented open access database."[13]

Since 2012[14], 30,000 researchers from over 90 countries[15] have registered to use UK Biobank. As of November 2023 there have been over 9,000[16] peer-reviewed publications using UK Biobank data, including over 3,000 in 2023.[17]

Based in Stockport, Greater Manchester, it is incorporated as a limited company[18] and registered charity[19] in England and Wales, and registered as a charity[20] in Scotland.[21][22][23]

In August 2022, UK Biobank celebrated its 20th anniversary.[24] UK Biobank is funded by the Medical Research Council (MRC), the Wellcome Trust, UK government and charitable sources, and philanthropic donations.[25][12]

History and development

[edit]

UK Biobank was conceived in the early 2000s,[26] with Professor Sir Rory Collins appointed as the Principal Investigator and Chief Executive of UK Biobank in 2005.[27] An incremental approach was adopted to developing the study procedures and technology, using systems designed and developed by the Clinical Trial Service Unit. This consisted of a series of pilot studies of increasing complexity and sophistication with interludes for assessment of results and additional scientific input. In-house trials were conducted during 2005, and a fully integrated clinic was run at Altrincham, Greater Manchester throughout Spring 2006 where 3,800 individuals were assessed. On 22 August 2006 it was announced that the main programme would recruit men and women aged between 40 and 69 based from up to 35 regional centres.[28] BBC’s Medical Editor Fergus Walsh was among the volunteer group.[29]

Following the initial pilot stage in the 2005-6 period, the main study began in April 2007 and by the end of that year 50,000 people had taken part. Recruitment reached 100,000 in April 2008, 200,000 in October 2008, 300,000 in May 2009, 400,000 in November 2009 and passed the 500,000 target in July 2010. Participant enrollment was declared complete in August 2010.[30] The volunteers were largely healthy, wealthy and white European. Rather than recruiting more participants into the biobank, the organisation is helping other institutions establish and run similar initiatives.[31] However recruitment proved more efficient than hoped and only 22 centres had been opened when the recruitment target of 500,000 was reached in 2010.

In May 2023, UKRI announced that UK Biobank was set to receive £127.6m to move to a purpose-built facility at Bruntwood SciTech’s Manchester Science Park.[32]

In October 2023, a number of funders including Eric Schmidt and Ken Griffin announced further funding for the next five years.[33][34]

Design

[edit]

Prospective participants were invited to visit an assessment centre, at which they completed an automated questionnaire and were interviewed about lifestyle, medical history and nutritional habits; basic variables such as weight, height, blood pressure etc. were measured; and blood and urine samples were taken. These samples were preserved so that it was possible to later extract DNA and measure other biologically important substances. During the whole duration of the study it was intended that all disease events, drug prescriptions and deaths of the participants are recorded in a database, taking advantage of the centralized UK National Health Service.[35][36]

During the initial physical examination, basic feedback was provided to the participant regarding their weight, height, BMI, blood pressure, lung vital capacity, bone density and intra-ocular pressure; however if any other medical problems were detected, neither the participant nor their physician would be notified. Problems detected later, such as genetic risk factors, were not conveyed to either participant or physician ("to ensure that volunteers are not penalised by insurance companies, for example, which may require customers to disclose the results of any genetic tests.").[37]

From 2012, researchers were able to apply to use the database (though they are not given accessto the volunteers, who will remain strictly anonymous). A typical study using the database might compare a sample of participants who developed a particular disease, such as cancer, heart disease, diabetes or Alzheimer's disease, with a sample of those that did not, in an attempt to measure the benefits, risk contribution and interaction of specific genes, lifestyles, and medications.

In 2017 researchers were able to access genetic data in the resource for the first time, specifically genotyping data for the whole cohort.[38][39] By 2017 Biobank participants had approximately 1.3 million hospitalisations, 40,000 cancer incidents with 14,000 of them having died.[40]

Initial information collected

[edit]

The study was initially launched with a visit consisting of the following:[40]

Once the visit-based assessment method was proven, the range of investigations was extended to include:[40]

Access to UK Biobank data

[edit]

The UK Biobank dataset was opened to applications from researchers in March 2012.[41] The resource is available to scientists from the UK and outside, whether they work in the public or private sector, for industry, academia or a charity, subject to verification that the research is health-related and in the public interest. Researchers must register to be approved to use UK Biobank data.[42] Researchers are required to publish their results in an open source publication site or in an academic journal and return their findings to the UK Biobank.[40]

In 2021, UK Biobank launched its cloud-based Research Analysis Platform (UKB-RAP), providing information technology infrastructure to store and analyse UK Biobank's large dataset regardless of the researcher's own technological capabilities.[43] By 2023 the platform had over 5,000 users.[44] The platform is hosted by Amazon Web Services, which also pledged $1.5 million in research credits for early career researchers and researchers from low and low-middle income countries to reduce limitations when collating, storing and securely accessing data.[45]

By 2023 30,000 researchers had registered to use the resource and over 9,000 peer-reviewed articles based on UK Biobank data had been published.[46]

Data additions

[edit]

Since the completion of recruitment several new types of data have been added:

  • During 2011-12 participants who supplied an email address were asked to assist by completing web-based dietary questionnaires, with the aim of combining a series of daily 'snapshots' to form a picture of overall nutrition. 176,012 of the participants responded at least once and 27,535 completed four questionnaires over a 16-month period.[40]
  • During 2012–13 25,000 participants at the Stockport centre were asked to attend the assessment centre to repeat the initial measurements. It was intended to repeat these assessments every few years.[40]
  • In 2013 to 2015, Axivity AX3 tri-axial wrist physical activity monitors were distributed to 100,000 participants, which recorded week-long triaxial acceleration at 100 Hz.[47][48] This data was centrally processed, and listed on the Data Showcase.[49][50]
  • In 2014 and 2015 120,000 participants completed a questionnaire on cognitive functions. Four of the tests were repeats of the initial assessment and two tests (symbol digit substitution and trail making) were new.[40]
  • A new type of assessment centre opened in 2014 to collect imaging data. The visits extended the initial dataset to include magnetic resonance imaging (MRI) scans of brain[51][52][53][54] heart and abdomen, as well as neck-to-knee volumetric MRI scans, whole body dual-energy X-ray absorptiometry (DXA) scan of bones and joints, ultrasound measurements of the carotid arteries and resting 12-lead electrocardiogram (ECG). Initial data on 5,000 participants was released at the end of 2015 and by January 2024 over 25,000 participants had been scanned. It is planned to scan 100,000 participants, and to do additional repeat scans on 60,000 of these 2–3 years later.[40][55]
  • In 2015 and 2016, 117,500 participants completed questionnaires on occupational history and related medical information.[40]
  • In 2016 and 2017 137,400 participants completed questionnaires on mental health events including subjective well-being estimates, psychotic experiences, self-harm behaviours, traumatic events and cannabis and alcohol use.[40]
  • A set of additional assays on the blood and urinary samples were being conducted in 2016 and 2017[40] with blood results expected to be released in Q4/2018.
  • A genomic assay of 820,967 SNPs was conducted on the participants blood samples. Data from an initial 150,000 participants were released in 2015, the remainder in July 2017,[56][39] and the first results in October 2018.[57][58]
  • Information from UK registries of death (from 2006) and cancer (Scotland from 1957, England and Wales from 1995) were linked to the main Biobank dataset on an ongoing basis.[40]
  • Data from NHS hospital inpatient records (England from 1996, Scotland from 1997 and Wales from 1998) were linked to the main dataset on an ongoing basis.[40]
  • In 2019 exome sequence data from 50,000 persons was released, with 470,000 being available in 2023.[59]
  • In 2020 20,000 volunteers agreed to collect and send a monthly blood sample for analysis of SARS-CoV-2 antibodies. They included existing Biobank participants and their children and adult grandchildren living in separate households.[60]
  • In 2021 NMR metabolomic data on approximately 121,000 persons was released.[61]
  • In June 2021 a subset of volunteers who had acknowledged that they had already received at least their first Covid-19 vaccine dose, were asked to participate in a study to determine if their Covid-19 antibodies were as a result of their vaccination or from a prior infection.
  • In 2023, UK Biobank released the whole genome sequencing data of all 500,000 participants, the largest number of whole genome sequences ever released for medical research.[62][63] The release was supported by UKRI, Wellcome, industry partners including Amgen, AstraZeneca, GSK, and Johnson & Johnson, with sequencing conducted by deCODE Genetics and the Wellcome Sanger Institute.[64]

Findings

[edit]

Proteomic data

[edit]

Using samples from UK Biobank, the largest ever study examining the links between genetic variants and proteins in the blood was released in 2023, identifying over 14,000 associations[65] between common genetic variants and proteins circulating in the bloodstream. This proteomic dataset within UK Biobank has since been used to identify the protein signatures of the earliest stages of dementia, which could be used to develop blood tests[66] to diagnose dementia and Alzheimer’s up to fifteen years before diagnosis and, in another study, potentially predict cancer up to seven years before diagnosis.

Polygenic risk scores

[edit]

UK Biobank has led to the development of the polygenic risk score[67] concept, using UK Biobank data to pinpoint individuals who may be at a high risk of developing common diseases including cardiovascular disease and lung cancer[68][69] and to identify “functionally important variants” across the genome.[70] UK Biobank data has also been used in combination with PrimateAI-3D, an AI algorithm trained on common genetic variants found in the genomes of 233 primate species, to identify potentially harmful mutations in humans.[71]

Activity monitoring data to predict Parkinson's

[edit]

The physical activity data of 100,000 participants from UK Biobank was collected from smartwatches over a seven-day period. This data has been used to find that smartwatch data could be used to help predict Parkinson’s disease up to seven years[72] prior to symptoms appearing.[73]

Mental health

[edit]

A 2023 review found that participants with sense of meaning and purpose in life have a decreased risk of dementia.[74]

Road noise

[edit]

A 2022 review of UK Biobank data found that road traffic noise exposure increases risk of CVD mortality, stroke and all-cause mortality.[75]

Effects of diet

[edit]

Reviews of UK Biobank data have found that pescatarians and vegetarians have a lower risk of colorectal and prostate cancer compared to red meat eaters.[76] Consumption of processed meat increases risk of breast cancer.[77] They have also found that men with higher total and central adiposity have an increased risk of prostate cancer death.[78]

COVID-19 repeat imaging study

[edit]

UK Biobank collected repeat imaging scans on approximately 2,000 participants who had been infected with SARS-CoV-2 (the COVID-19 virus) and compared the images to those obtained before the pandemic to investigate the longer-term effects of COVID-19 on internal organs.[79] This was the first longitudinal study of this size on COVID-19 whereby participants were scanned before they contracted the disease. One resulting piece of research investigated data from 785 participants of UK Biobank (aged 51–81 years) imaged twice using magnetic resonance imaging, including 401 cases who tested positive for infection with SARS-CoV-2 between their two scans. This research showed that even mild infection with the virus that causes COVID-19 results in physical changed to the brain. A reduction in brain areas related to smell processing was found.[80]

Type 1 Diabetes incidence rates

[edit]

In 2017 research from University of Exeter using UK Biobank data found that, rather than being a disease of children and young adults, the incidence rate of Type 1 diabetes remains equal up to age 60. In the findings 58% of type 1 diabetes cases were diagnosed prior to 30 years and 42% were diagnosed in adults between the ages of 31-60.[81]

Ethics and governance

[edit]

The UK Biobank project operates within the terms of an Ethics and Governance Framework.[82][83][84] The Framework describes a series of standards to which UK Biobank will operate during the creation, maintenance and use of the resource and it elaborates on the commitments that are involved to those participating in the project, researchers and the public more broadly. The independent UK Biobank Ethics and Governance Council provides advice to the project and monitors its conformity with the Framework.[85] The Council also advises more generally on the interests of research participants and the general public in relation to the project.[citation needed]

The UK Biobank Board is accountable to the members of the company (the Medical Research Council and The Wellcome Trust) and acts as company directors and as charity trustees. It is chaired by Lord Kakkar,[86] who succeeded Sir Michael Rawlins in January 2020.

Opinion

[edit]

The project has been generally praised for its ambitious scope and unique potential. A scientific review panel concluded, the "UK Biobank has the potential, in ways that are not currently available elsewhere, to support a wide range of research".[30] Colin Blakemore, chief executive of the MRC, predicted it "will provide scientists with extraordinary information"[28] and "grow into a unique resource for future generations."[30]

There was some early criticism, however. GeneWatch UK, a pressure group that claims to promote the responsible use of genetic information, asserted that the complexity of the programme could result in the finding of "false links between genes and disease",[30] and expressed concern that the genetic information from patients could be patented for commercial purposes. The UK Biobank's chief executive described such a risk as "extremely low, if it exists at all."[28]

Some literature has raised concerns that the UK Biobank is not representative of the diversity of the UK population or is not applicable to diverse populations.[87][88]

In 2023 the UK’s Secretary of State for Science, Innovation and Technology Michelle Donelan described UK Biobank as “mak[ing] an unparalleled contribution to science across the whole world, by putting invaluable information at researchers’ fingertips. It is without question a jewel in the crown of UK science, and an envy of the world”.[89]

See also

[edit]

References

[edit]
  1. ^ a b Bahcall, Orli G. (22 October 2018). "UK Biobank — a new era in genomic medicine". Nature Reviews Genetics. pp. 737–737. doi:10.1038/s41576-018-0065-3.
  2. ^ Watts, Geoff (30 March 2012). "UK Biobank opens its data vaults to researchers". BMJ. 344: e2459. doi:10.1136/bmj.e2459. ISSN 1756-1833.
  3. ^ a b c Sample, Ian (30 November 2023). "UK Biobank and the masses of medical data that became key to genetic research". The Guardian.
  4. ^ Smith, Julia Llewellyn (12 September 2023). "How people like you are contributing to the cure for cancer".
  5. ^ Smith, Julia Llewellyn (12 September 2023). "How people like you are contributing to the cure for cancer".
  6. ^ Whipple, Tom (16 February 2024). "UK Biobank: We're in the prime of our life — because everyone is dying".
  7. ^ Hirschler, Ben (30 March 2012). "Mid-life Britain opens doors for disease research". Reuters.
  8. ^ Walsh, Fergus (18 May 2023). "Ageing body scans to aid understanding of why diseases occur". BBC News.
  9. ^ Callaway, Ewen (30 November 2023). "World's biggest set of human genome sequences opens to scientists". Nature. doi:10.1038/d41586-023-03763-3.
  10. ^ Walsh, Fergus (18 May 2023). "Ageing body scans to aid understanding of why diseases occur". BBC News.
  11. ^ "UK Biobank's reimaging colossus". Nature Biotechnology. 8 November 2022. doi:10.1038/s41587-022-01575-w.
  12. ^ a b Whipple, Tom (16 February 2024). "UK Biobank: We're in the prime of our life — because everyone is dying".
  13. ^ "UK Biobank". Nature. 11 October 2018.
  14. ^ "UK Biobank data on 500,000 people paves way to precision medicine". Nature. 10 October 2018. doi:10.1038/d41586-018-06950-9.
  15. ^ Walsh, Fergus (18 May 2023). "Ageing body scans to aid understanding of why diseases occur". BBC News.
  16. ^ Offord, Catherine (29 November 2023). "UK Biobank releases half a million whole-genome sequences for biomedical research". Science.
  17. ^ Law, Tara (2 May 2024). "Rory Collins". TIME.
  18. ^ Registration number 4978912
  19. ^ "Burchrusks/sandbox, registered charity no. 1101332". Charity Commission for England and Wales.
  20. ^ "Burchrusks/sandbox, Registered Charity no. SC039230". Office of the Scottish Charity Regulator.
  21. ^ Sudlow, Cathie; Gallacher, John; Allen, Naomi; Beral, Valerie; Burton, Paul; Danesh, John; Downey, Paul; Elliott, Paul; Green, Jane; Landray, Martin; Liu, Bette; Matthews, Paul; Ong, Giok; Pell, Jill; Silman, Alan; Young, Alan; Sprosen, Tim; Peakman, Tim; Collins, Rory (2015). "UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age". PLOS Medicine. 12 (3): e1001779. doi:10.1371/journal.pmed.1001779. PMC 4380465. PMID 25826379.
  22. ^ Allen, N. E.; Sudlow, C.; Peakman, T.; Collins, R. (2014). "UK Biobank Data: Come and Get It". Science Translational Medicine. 6 (224): 224ed4. doi:10.1126/scitranslmed.3008601. PMID 24553384. S2CID 206684216.
  23. ^ Collins, Rory (2012). "What makes UK Biobank special?". The Lancet. 379 (9822): 1173–1174. doi:10.1016/S0140-6736(12)60404-8. PMID 22463865. S2CID 205965558.
  24. ^ Mullard, Asher (11 August 2022). "The UK Biobank at 20". Nature Reviews Drug Discovery. doi:10.1038/d41573-022-00137-8.
  25. ^ "How 500,000 Britons are critical to assessing global disease risk". www.ft.com. Financial Times. 22 August 2018.
  26. ^ Sample, Ian (30 November 2023). "UK Biobank and the masses of medical data that became key to genetic research". The Guardian.
  27. ^ Coghlan, Andy (30 March 2012). "Biobank promises to pinpoint the cause of disease". New Scientist. New Scientist.
  28. ^ a b c Sarah Hall: £61m medical experiment begins The Guardian
  29. ^ Walsh, Fergus (18 May 2023). "Ageing body scans to aid understanding of why diseases occur". BBC News.
  30. ^ a b c d Biobank set for national roll out. BBC News, 21 August 2006
  31. ^ "How 500,000 Britons are critical to assessing global disease risk". Financial Times. 22 August 2018. Retrieved 1 October 2018.
  32. ^ Hatmaker, Julia (25 May 2023). "UK Biobank confirms move to Manchester Science Park". Place North West.
  33. ^ "UK Biobank to scale though £32m philanthropic partnership". BusinessCloud. 31 October 2023.
  34. ^ Peel, Michael; Agnew, Harriet (29 October 2023). "Ken Griffin and Eric Schmidt invest $10mn each in UK genetics database". www.ft.com. Financial Times.
  35. ^ Draft protocol for the UK Biobank Archived 2006-02-14 at the Wayback Machine, 14 February 2002
  36. ^ Reviewers' comments on Draft protocol, and responses
  37. ^ Andy Coghlan: One million people, one medical gamble. New Scientist, 20 January 2006
  38. ^ Regalado, Antonio (15 November 2017). "UK Biobank supercharges medicine with gene data on 500,000 Brits". MIT Technology Review. Retrieved 25 June 2018.
  39. ^ a b Zhang, Sarah (6 November 2017). "What Happens When You Put 500,000 People's DNA Online". The Atlantic. Retrieved 7 November 2017.
  40. ^ a b c d e f g h i j k l m Littlejohns, Thomas J.; Sudlow, Cathie; Allen, Naomi E.; Collins, Rory (2017). "UK Biobank: opportunities for cardiovascular research". European Heart Journal. 40 (14): 1158–1166. doi:10.1093/eurheartj/ehx254. PMC 6451771. PMID 28531320.
  41. ^ (30 March 2012) UK biobank opens to researchers BBC News, Health, Retrieved 30 March 2015
  42. ^ Conroy, M.; Sellors, J.; Effingham, M.; Littlejohns, T. J.; Boultwood, C.; Gillions, L.; Sudlow, C. L. M.; Collins, R.; Allen, N. E. (8 July 2019). "The advantages of UK Biobank's open‐access strategy for health research". Journal of Internal Medicine. pp. 389–397. doi:10.1111/joim.12955.
  43. ^ Chipman, Andrea (30 November 2023). "UK Biobank unveils new data, launching new era for treatments and cures". Digital Health.
  44. ^ "DNAnexus-enabled UK Biobank Research Analysis Platform Surpasses 5,000 Users in Two Years". Informatics from Technology Networks. 2 October 2023.
  45. ^ Albert, Helen (17 November 2021). "Genomic Data From 200,000 UK Biobank Participants Available to Researchers". Inside Precision Medicine.
  46. ^ Offord, Catherine (29 November 2023). "UK Biobank releases half a million whole-genome sequences for biomedical research". Science.
  47. ^ (2015) UK Biobank; Large Scale Data Collection Axivity company web page, Retrieved 30 March 2015
  48. ^ "AX3 3-axis logging accelerometer". Open Movement. 8 December 2020. Retrieved 8 December 2020.
  49. ^ Doherty, Aiden; et al. (1 February 2017). "Large Scale Population Assessment of Physical Activity Using Wrist Worn Accelerometers: The UK Biobank Study". PLOS ONE. 12 (2): e0169649. Bibcode:2017PLoSO..1269649D. doi:10.1371/journal.pone.0169649. PMC 5287488. PMID 28146576.
  50. ^ "Showcase: Physical activity measurement". UK Biobank Data. Retrieved 16 March 2022.
  51. ^ Miller, K.L. (2016). "Multimodal population brain imaging in the UK Biobank prospective epidemiological study". Nature Neuroscience. 19 (11): 1523–1536. doi:10.1038/nn.4393. PMC 5086094. PMID 27643430.
  52. ^ Alfaro-Almagro, F. (2016). "Image processing and Quality Control for the first 10,000 brain imaging datasets from UK Biobank". NeuroImage. 19: 1523–1536. doi:10.1016/j.neuroimage.2017.10.034. PMC 5770339. PMID 29079522.
  53. ^ Alfaro Almagro, F. (25 April 2017). "Image Processing and Quality Control for the first 10,000 Brain Imaging Datasets from UK Biobank". bioRxiv 10.1101/130385.
  54. ^ Smith SM, Douaud G, Chen W, Hanayik T, Alfaro-Almagro F, Sharp K; et al. (2021). "An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank". Nat Neurosci. 24 (5): 737–745. doi:10.1038/s41593-021-00826-4. PMC 7610742. PMID 33875891.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  55. ^ Foster, Paul J.; Atan, Denize; Khawaja, Anthony; Lotery, Andrew; MacGillivray, Tom; Owen, Christopher G.; Patel, Praveen J.; Petzold, Axel; Rudnicka, Alicja; Sun, Zihan; Sheard, Simon; Allen, Naomi; Consortium, UK Biobank and UK Biobank Eye and Vision (2023). "Cohort profile: Cohort profile: rationale and methods of UK Biobank repeat imaging study eye measures to study dementia". BMJ Open. 13 (6). doi:10.1136/bmjopen-2022-069258. PMID 37355273.
  56. ^ Welsh, Samantha; Peakman, Tim; Sheard, Simon; Almond, Rachael (1 January 2017). "Comparison of DNA quantification methodology used in the DNA extraction protocol for the UK Biobank cohort". BMC Genomics. 18 (1): 26. doi:10.1186/s12864-016-3391-x. ISSN 1471-2164. PMC 5217214. PMID 28056765.
  57. ^ Clare, B. (2018). "The UK Biobank resource with deep phenotyping and genomic data". Nature. 562 (7726): 203–209. Bibcode:2018Natur.562..203B. doi:10.1038/s41586-018-0579-z. PMC 6786975. PMID 30305743.
  58. ^ Elliott, L.T. (2018). "Genome-wide association studies of brain imaging phenotypes in UK Biobank". Nature. 562 (7726): 210–216. Bibcode:2018Natur.562..210E. doi:10.1038/s41586-018-0571-7. PMC 6786974. PMID 30305740.
  59. ^ Curtis, David (13 November 2023). "Analysis of Rare Variants in 470,000 Exome-Sequenced UK Biobank Participants Implicates Novel Genes Affecting Risk of Hypertension". Pulse. 11 (1): 9. doi:10.1159/000535157. PMID 38090255.
  60. ^ "UK Biobank reveals substantial variation in rates of previous COVID-19 infection across the UK". www.ukbiobank.ac.uk. UK Biobank. 30 July 2020. Retrieved 18 August 2020.
  61. ^ Ritchie, Scott C.; Surendran, Praveen; Karthikeyan, Savita; Lambert, Samuel A.; Bolton, Thomas; Pennells, Lisa; Danesh, John; Di Angelantonio, Emanuele; Butterworth, Adam S.; Inouye, Michael (2023). "Quality control and removal of technical variation of NMR metabolic biomarker data in ~120,000 UK Biobank participants". Scientific Data. 10 (1): 64. Bibcode:2023NatSD..10...64R. doi:10.1038/s41597-023-01949-y. Retrieved 12 September 2023.
  62. ^ Sample, Ian (30 November 2023). "Genetic data on 500,000 volunteers in UK to be released for scientific study". The Guardian. The Guardian.
  63. ^ Curtis, David (13 November 2023). "Analysis of Rare Variants in 470,000 Exome-Sequenced UK Biobank Participants Implicates Novel Genes Affecting Risk of Hypertensionmplicates Novel Genes Affecting Risk of Hypertension". Karger. pp. 9–16. doi:10.1159/000535157.
  64. ^ Joseph, Andrew (29 November 2023). "With latest tranche, U.K. Biobank has genome sequences from 500,000 people available for research available for research". STAT.
  65. ^ Sun, Benjamin B.; Chiou, Joshua; Traylor, Matthew; Benner, Christian; Hsu, Yi-Hsiang; Richardson, Tom G.; Surendran, Praveen; Mahajan, Anubha; Robins, Chloe; Vasquez-Grinnell, Steven G.; Hou, Liping; Kvikstad, Erika M.; Burren, Oliver S.; Davitte, Jonathan; Ferber, Kyle L.; Gillies, Christopher E.; Hedman, Åsa K.; Hu, Sile; Lin, Tinchi; Mikkilineni, Rajesh; Pendergrass, Rion K.; Pickering, Corran; Prins, Bram; Baird, Denis; Chen, Chia-Yen; Ward, Lucas D.; Deaton, Aimee M.; Welsh, Samantha; Willis, Carissa M.; Lehner, Nick; Arnold, Matthias; Wörheide, Maria A.; Suhre, Karsten; Kastenmüller, Gabi; Sethi, Anurag; Cule, Madeleine; Raj, Anil; Kang, Hyun Ming; Burkitt-Gray, Lucy; Melamud, Eugene; Black, Mary Helen; Fauman, Eric B.; Howson, Joanna M. M.; Kang, Hyun Min; McCarthy, Mark I.; Nioi, Paul; Petrovski, Slavé; Scott, Robert A.; Smith, Erin N.; Szalma, Sándor; Waterworth, Dawn M.; Mitnaul, Lyndon J.; Szustakowski, Joseph D.; Gibson, Bradford W.; Miller, Melissa R.; Whelan, Christopher D. (4 October 2023). "Plasma proteomic associations with genetics and health in the UK Biobank". Nature. pp. 329–338. doi:10.1038/s41586-023-06592-6.
  66. ^ Sample, Ian (12 February 2024). "Early blood test to predict dementia is step closer as biological markers identified". The Guardian.
  67. ^ Jung, Hyein; Jung, Hae-Un; Baek, Eun Ju; Kwon, Shin Young; Kang, Ji-One; Lim, Ji Eun; Oh, Bermseok (13 February 2024). "Integration of risk factor polygenic risk score with disease polygenic risk score for disease prediction". Nature.com. Nature. doi:10.1038/s42003-024-05874-7.
  68. ^ Massey, Nina (10 August 2023). "Raised blood sugar levels 'linked to increased risk of cardiovascular disease'". The Independent.
  69. ^ Newton, Storm (3 October 2023). "Computer modelling 'could simplify lung cancer screening'". The Independent.
  70. ^ Mullard, Asher (11 August 2022). "The UK Biobank at 20". Nature Reviews Drug Discovery. doi:10.1038/d41573-022-00137-8.
  71. ^ Cookson, Clive (1 June 2023). "'Primate AI algorithm' predicts genetic health risks". www.ft.com. Financial Times.
  72. ^ "Smart watches could detect Parkinson's before symptoms appear". www.ukri.org. 3 July 2023.
  73. ^ Rackham, Annabel (3 July 2023). "Smartwatches may provide early Parkinson's diagnosis". BBC News.
  74. ^ Sutin, Angelina; Luchetti, Martina; Aschwanden, Damaris; Stephan, Yannick; Sesker, Amanda; Terracciano, Antonio (23 October 2022). "Sense of meaning and purpose in life and risk of incident dementia: New data and meta-analysis". PubMed Central.
  75. ^ Hao, Guang; Zuo, Lei; Weng, Xueqiong; Fei, Qiaoyuan; Zhang, Zugui; Chen, Li; Wang, Zengwu; Jing, Chunxia (September 2022). "Associations of road traffic noise with cardiovascular diseases and mortality: Longitudinal results from UK Biobank and meta-analysis". Environmental Research.
  76. ^ Parra-Soto, Solange; Ahumada, Danay; Petermann-Rocha, Fanny; Boonpoor, Jirapitcha; Gallegos, Jose Lara; Anderson, Jana; Sharp, Linda; Malcomson, Fiona C.; Livingstone, Katherine M.; Mathers, John C.; Pell, Jill P.; Ho, Frederick K.; Celis-Morales, Carlos (24 February 2022). "Association of meat, vegetarian, pescatarian and fish-poultry diets with risk of 19 cancer sites and all cancer: findings from the UK Biobank prospective cohort study and meta-analysis". BMC Medicine. p. 79. doi:10.1186/s12916-022-02257-9.{{cite web}}: CS1 maint: unflagged free DOI (link)
  77. ^ Anderson, Jana J.; Darwis, Narisa D. M.; Mackay, Daniel F.; Celis-Morales, Carlos A.; Lyall, Donald M.; Sattar, Naveed; Gill, Jason M. R.; Pell, Jill P. (February 2018). "Red and processed meat consumption and breast cancer: UK Biobank cohort study and meta-analysis". European Journal of Cancer. pp. 73–82. doi:10.1016/j.ejca.2017.11.022.
  78. ^ Perez-Cornago, Aurora; Dunneram, Yashvee; Watts, Eleanor L.; Key, Timothy J.; Travis, Ruth C. (5 May 2022). "Adiposity and risk of prostate cancer death: a prospective analysis in UK Biobank and meta-analysis of published studies". BMC Medicine. doi:10.1186/s12916-022-02336-x.{{cite web}}: CS1 maint: unflagged free DOI (link)
  79. ^ Feng, Qi; Lacey, Ben; Bešević, Jelena; Omiyale, Wemimo; Conroy, Megan; Starkey, Fenella; Calvin, Catherine; Callen, Howard; Bramley, Laura; Welsh, Samantha; Young, Allen; Effingham, Mark; Young, Alan; Collins, Rory; Holliday, Jo; Allen, Naomi (29 August 2023). "UK biobank: Enhanced assessment of the epidemiology and long-term impact of coronavirus disease-2019". Cambridge University Press. doi:10.1017/pcm.2023.18.
  80. ^ Douaud, Gwenaëlle; Lee, Soojin; Alfaro-Almagro, Fidel; Arthofer, Christoph; Wang, Chaoyue; McCarthy, Paul; Lange, Frederik; Andersson, Jesper L. R.; Griffanti, Ludovica; Duff, Eugene; Jbabdi, Saad; Taschler, Bernd; Keating, Peter; Winkler, Anderson M.; Collins, Rory; Matthews, Paul M.; Allen, Naomi; Miller, Karla L.; Nichols, Thomas E.; Smith, Stephen M. (April 2022). "SARS-CoV-2 is associated with changes in brain structure in UK Biobank". Nature. pp. 697–707. doi:10.1038/s41586-022-04569-5.
  81. ^ Tucker, Miriam E. (4 December 2017). "Needle in a Haystack: Type 1 Diabetes Arises Equally in Adulthood". Medscape.
  82. ^ UK Biobank Ethics and Governance Framework Archived 2008-12-27 at the Wayback Machine. UK Biobank, October 2007
  83. ^ Ethics and Governance Framework for UK Biobank published for comment. Wellcome Trust, 22 September 2003
  84. ^ Rules for UK Biobank revealed. BBC News, 24 September 2003
  85. ^ Ethics and Governance Council formed to oversee UK Biobank Wellcome Trust, 1 November 2004
  86. ^ "Our Board". UK Biobank. Retrieved 2 December 2020.
  87. ^ "Lack Of Diversity In Genetic Databases Hampers Research". NPR.org. Retrieved 3 April 2020.
  88. ^ Agrawal, Raag; Prabakaran, Sudhakaran (5 March 2020). "Big data in digital healthcare: lessons learnt and recommendations for general practice". Heredity. 124 (4): 525–534. doi:10.1038/s41437-020-0303-2. ISSN 0018-067X. PMC 7080757. PMID 32139886.
  89. ^ Chapman, Stephen (9 February 2024). "£21million Government bonus for UK Biobank - Prolific North".
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