User:Benjah-bmm27/degree/3/SM

Bioinorganic Chemistry, SM

• Porphyrins
  • Haem

Metalloproteins

• Metalloproteins
• Iron-sulfur proteins
• Haemoproteins
  • Protoporphyrin IX
  • Myoglobin
  • Haemoglobin
  • Cytochromes
    • Cytochrome P450
    • Cytochrome c
• Copper proteins
  • Plastocyanin
  • Ceruloplasmin

See also

• Bioorganometallic chemistry
• Dioxygen complex

The roles of metals in biology

Proteins: transport and storage (Fe, Cu)

• Oxygen transport
  • Myoglobin (Fe)
  • Haemoglobin (Fe)
  • Haemocyanin (Cu)

• Electron transport
  • Cytochrome c
  • Ferredoxins (FeS redox centre)
  • Copper blues

• Metal storage
  • Ferritin
  • Transferrin
  • Ceruloplasmin

Enzymes: catalysis

• Redox (Fe, Cu, Mo)
• Nitrogenase (Fe, Mo, V) — converts N₂ to NH₃ at room temperature and atmospheric pressure
• Hydrogenase (Fe, Ni) — converts H₂ to H⁻
• Superoxide dismutase (Fe, Cu, Mn) — converts a by-product of many biochemical reactions, superoxide, O₂⁻ to OH⁻ and H₂O

Transport/storage

• Siderophores (Fe) — peptide-based macrocycles secreted by bacteria into the environment to scavenge Fe and bring it back to the cell
• Electrolytes: Na, K
• Lewis acids: Mg, Zn
• Skeletal (bone, teeth): Ca

Haem metalloproteins in electron transfer — cytochrome c

• Cytochrome c
  • PDB 3CYT

Haem metalloproteins in enzyme catalysis — cytochrome P450

• Cytochrome P450
  • PDB-101 Structural View of Biology – Cytochrome p450
  • PDB 1W0E – Human Cytochrome P450 3A4
  • Cytochrome P450 bound to its substrate, camphor: PDB 3L63