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User:Bawanio/Difference between Cannabis indica and Cannabis sativa

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There are several key differences between Cannabis indica and Cannabis sativa. These include height and stature, internodal length, leaf size and structure, buds size and density, flowering time, odour, smoke and effects.[1] Indica plants tend to grow shorter and bushier than the sativa plants. Indica strains tend to have wide, short leaves with short wide blades, whereas sativa strains have long leaves with thin long blades. The buds of indica strains tend to be wide, dense and bulky, while sativa strains are likely to be long, sausage shaped flowers.[2]

During the 1970s, Cannabis indica strains from Afghanistan and Northern Pakistan particularly from the Hindu Kush mountain range were brought to the United States, where the first hybrids with Cannabis sativa plants from equatorial areas were developed, widely spreading marijuana cultivation throughout the States.[3]

The name indica originally referred to the geographical area in which the plant was grown, leading to widespread public taxonomic misconceptions.[4]

Human intervention has produced variation within the species and some authorities only recognize one species in the genus that has had divergent selective pressure to either produce plants with more fiber or plants with greater THC content.[5] Large variability exists within either species, and there is an expanding discussion whether the existing paradigm used to differentiate species adequately represents the variability found within the genus Cannabis.[6][7][8] There are five chemotaxonomic types of Cannabis: one with high levels of THC, one which is more fibrous and has higher levels of CBD, one that is an intermediate between the two, another one with high levels of cannabigerol (CBG), and the last one almost without cannabinoids.[9]

Cannabis strains with relatively high CBD:THC ratios are less likely to induce anxiety than vice versa.[10] This may be due to CBD's antagonistic effects at the cannabinoid receptors, compared to THC's partial agonist effect.[11] CBD is also a 5-HT1A receptor (serotonin) agonist, which may also contribute to an anxiolytic-content effect.[12] The effects of sativa are well known for its cerebral high, while indica is well known for its sedative effects which some prefer for night time use.[12] Both types are used as medical cannabis. Indica plants are normally shorter and stockier than sativas.[13] Indicas have broader, deeply serrated leaves and a compact and dense flower cluster.[citation needed]

Cannabinoids

On average, Cannabis indica has higher levels of THC compared to CBD, whereas Cannabis sativa has lower levels of THC to CBD.[14] However, huge variability exists within either species. A 2015 study shows the average THC content of the most popular herbal cannabis products in the Netherlands has decreased slightly since 2005.[15]

In the recent era of cannabis breeding higher-ratio CBD strains are being developed from Indica origins that may test out as 1:1 (CBD-THC balanced) or even as high as a 22:1 (CBD dominant).

There are three chemotaxonomic types of Cannabis: one with high levels of THC, one which is more fibrous and has higher levels of CBD, and one that is an intermediate between the two.[14][13]

Cannabis strains with CBD:THC ratios above 5:2 are likely to be more relaxing and produce less anxiety than vice versa. This may be due to CBD's antagonistic effects at the cannabinoid receptors, compared to THC's partial agonist effect.[citation needed][dubiousdiscuss] CBD is also a 5-HT1A receptor (serotonin) agonist, which may also contribute to an anxiolytic-content effect.[12] The effects of sativa are well known for its cerebral high. Users can expect a more vivid and uplifting high, while indica is well known for its sedative effects which some prefer for night time use. Indica possesses a more calming, soothing, and numbing experience in which can be used to relax or relieve pain. Both types are used as medical cannabis.

Plants with elevated levels of propyl cannabinoids, including tetrahydrocannabivarin (THCV), have been found in populations of Cannabis indica from India, Nepal, Thailand, Afghanistan, and Pakistan, as well as southern and western Africa. THCV levels up to 53.7% of total cannabinoids have been reported[14][16]

Terpenes

Sativa ancestry is associated with farnesene and bergamotene, while Indica ancestry is associated with myrcene, elemene, and sesquiterpene alcohols.[17][page needed][

  1. ^ "Indica vs Sativa – Differences". Freedom Seeds. Archived from the original on 2014-09-09. Retrieved 2014-09-09.
  2. ^ Ed, Rosenthal (2010). Marijuana Grower's Handbook (Ask ed.). Oakland, California: Quick American Publishing. p. 40. ISBN 978-0-932551-46-7.
  3. ^ Tom Flowers, Marijuana flower forcing, Quick American Archives, 1997, p.48
  4. ^ Nakamura, George (1973). "The forensic identification of marijuana: some questions and answers". Journal of Police Science and Administration: 102–112.
  5. ^ Suman Chandra; Hemant Lata; Mahmoud A. ElSohly (23 May 2017). Cannabis sativa L. - Botany and Biotechnology. Springer. pp. 54–. ISBN 978-3-319-54564-6.
  6. ^ Piomelli, Daniele; Russo, Ethan B. (2016-01-14). "The Cannabis sativa Versus Cannabis indica Debate: An Interview with Ethan Russo, MD". Cannabis and Cannabinoid Research. 1 (1): 44–46. doi:10.1089/can.2015.29003.ebr. PMC 5576603. PMID 28861479.
  7. ^ Aizpurua-ppOlaizola, Oier; Omar, Jone; Navarro, Patricia; Olivares, Maitane; Etxebarria, Nestor; Usobiaga, Aresatz (2014-10-23). "Identification and quantification of cannabinoids in Cannabis sativa L. plants by high performance liquid chromatography-mass spectrometry". Analytical and Bioanalytical Chemistry. 406 (29): 7549–7560. doi:10.1007/s00216-014-8177-x. ISSN 1618-2642. PMID 25338935. S2CID 206916401.
  8. ^ Hazekamp, A.; Fischedick, J. T. (2012-07-01). "Cannabis - from cultivar to chemovar". Drug Testing and Analysis. 4 (7–8): 660–667. doi:10.1002/dta.407. ISSN 1942-7611. PMID 22362625.
  9. ^ Mandolino, Giuseppe; Bagatta, Manuela; Carboni, Andrea; Ranalli, Paolo; Meijer, Etienne de (2003-03-01). "Qualitative and Quantitative Aspects of the Inheritance of Chemical Phenotype in Cannabis". Journal of Industrial Hemp. 8 (2): 51–72. doi:10.1300/J237v08n02_04. ISSN 1537-7881. S2CID 84817948.
  10. ^ Ethan B Russo; Virginia M Tyler (22 December 2015). Handbook of Psychotropic Herbs: A Scientific Analysis of Herbal Remedies for Psychiatric Conditions. Routledge. pp. 233–. ISBN 978-1-136-38607-7.
  11. ^ "Marijuana Chemicals Cannabinoids, Terpenes, Flavonoids (THC and CBD)". Howtogrowmarijuana.com. Retrieved 20 August 2021.{{cite web}}: CS1 maint: url-status (link)
  12. ^ a b c J.E. Joy; S. J. Watson Jr.; J.A. Benson Jr (1999). Marijuana and Medicine: Assessing The Science Base. Washington D.C: National Academy of Sciences Press. ISBN 978-0-585-05800-9.
  13. ^ a b Fischedick, Justin Thomas; Hazekamp, Arno; Erkelens, Tjalling; Choi, Young Hae; Verpoorte, Rob (December 2010). "Metabolic fingerprinting of Cannabis sativa L., cannabinoids and terpenoids for chemotaxonomic and drug standardization purposes". Phytochemistry. 71 (17–18): 2058–2073. doi:10.1016/j.phytochem.2010.10.001. PMID 21040939.
  14. ^ a b c Karl W. Hillig; Paul G. Mahlberg (2004). "A chemotaxonomic analysis of cannabinoid variation in Cannabis (Cannabaceae)". American Journal of Botany. 91 (6): 966–975. doi:10.3732/ajb.91.6.966. PMID 21653452.
  15. ^ Niesink RJ, Rigter S, Koeter MW, Brunt TM (2015). "Potency trends of Δ9-tetrahydrocannabinol, cannabidiol and cannabinol in cannabis in the Netherlands: 2005-15". Addiction. 110 (12): 1941–50. doi:10.1111/add.13082. PMID 26234170.
  16. ^ Turner, C.E.; Hadley, K.W.; Fetterman, P. (1973). "Constituents of Cannabis Sativa L., VI: Propyl Homologues in Samples of Known Geographical Origin". J. Pharm. Sci. 62 (10): 1739–1741. doi:10.1002/jps.2600621045. PMID 4752132.
  17. ^ "Programm of the 28th Annual Symposium of the International Cannainoid Research Society" (PDF). 2018-06-03. Retrieved 2021-07-12.