User:Banerjee12/S-Nitrosylation
The reverse of S-nitrosylation is denitrosylation, principally an enzymically controlled process. Multiple enzymes have been described to date, which fall into two main classes mediating denitrosylation of protein and low molecular weight SNOs, respectively. S-Nitrosoglutathione reductase (GSNOR) is exemplary of the low molecular weight class; it accelerates the decomposition of S-nitrosoglutathione (GSNO) and of SNO-proteins in equilibrium with GSNO. The enzyme is highly conserved from bacteria to humans.[1] Thioredoxin (Trx)-related proteins, including Trx1 and 2 in mammals, catalyze the direct denitrosylation of S-nitrosoproteins[2][3][4] (in addition to their role in transnitrosylation[5]). Aberrant S-nitrosylation (and denitrosylation) has been implicated in multiple diseases, including heart disease,[6] cancer and asthma[7][8][9] as well as neurological disorders, including stroke,[10] chronic degenerative diseases (e.g., Parkinson's and Alzheimer's disease)[11][12][13][14], amyotrophic lateral sclerosis (ALS)[15], different psychiatric diseases (depression, schizophrenia, bipolar disorder), renal disease, lung disease (chronic pulmonary obstruction, lung cancer), and aging.[16]
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- ^ Stoyanovsky DA, Tyurina YY, Tyurin VA, Anand D, Mandavia DN, Gius D, Ivanova J, Pitt B, Billiar TR, Kagan VE. J. Am. Chem. Soc. 127:15815-23 (2005)
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- ^ Wu, Changgong; Liu, Tong; Wang, Yan; Yan, Lin; Cui, Chuanlong; Beuve, Annie; Li, Hong (2018). "Biotin Switch Processing and Mass Spectrometry Analysis of S-Nitrosated Thioredoxin and Its Transnitrosation Targets". Methods in Molecular Biology. Vol. 1747. Springer New York. pp. 253–266. doi:10.1007/978-1-4939-7695-9_20. ISBN 9781493976942. PMC 7136013. PMID 29600465.
- ^ Beuve, A; Wu, C; Cui, C; Liu, T; Jain, MR; Huang, C; Yan, L; Kholodovych, V; Li, H (14 April 2016). "Identification of novel S-nitrosation sites in soluble guanylyl cyclase, the nitric oxide receptor". Journal of Proteomics. 138: 40–7. doi:10.1016/j.jprot.2016.02.009. PMC 5066868. PMID 26917471.
- ^ Aranda E, López-Pedrera C, De La Haba-Rodriguez JR, Rodriguez-Ariza A. Curr. Mol. Med. 12(1):50-67 (2012)
- ^ Switzer CH, Glynn SA, Cheng RY, Ridnour LA, Green JE, Ambs S, Wink DA. Mol Cancer Res.Sep;10(9):1203-15.(2012)
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- ^ Uehara T, Nakamura T, Yao D, Shi Z-Q, Gu Z, Masliah E, Nomura Y, Lipton SA. Nature 2441(7092):513-7 (2006)
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- ^ Cho D-H, Nakamura T, Fang J, Cieplak P, Godzik A, Gu Z, Lipton SA. Science 324(5923):102-5 (2009)
- ^ Schonhoff CM, Matsuoka M, Tummala H, Johnson MA, Estevéz AG, Wu R, Kamaid A, Ricart KC, Hashimoto Y, Gaston B, Macdonald TL, Xu Z, Mannick JB. Proc. Natl. Acad. Sci. U S A 103(7):2404-9 (2006)
- ^ Jomova, Klaudia; Raptova, Renata; Alomar, Suliman Y.; Alwasel, Saleh H.; Nepovimova, Eugenie; Kuca, Kamil; Valko, Marian (2023-10). "Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging". Archives of Toxicology. 97 (10): 2499–2574. doi:10.1007/s00204-023-03562-9. ISSN 0340-5761.
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