User:AlexLee90/sandbox/Practice Sandbox

This is my Practice page. This page is for practice. brain. It is a neurological disorder Click here to link

Introduction

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For pictures go to commons.wikimedia.org

Cerebral lobes

Cerebral lobes

testing

Magnetofection is done through the use of super paramagnetic iron oxide nanoparticles coated with polyethylenimine. Iron oxide nanoparticles are ideal for biomedical applications in the body due to their biodegradable, cationic, non-toxic, and FDA-approved nature. Under gene transfer conditions, the receptors of interest are coated with the nanoparticles. The receptors will then hone and travel to the target of interest. Once the particle docks, the DNA is delivered to the cell via pinocytosis or endocytosis. Upon delivery, the temperature is increased ever so slightly, lysing the iron oxide nanoparticle and releasing the DNA. Overall, the technique is useful for combatting slow vector accumulation and low vector concentration at target areas. The technique is also customizable to the physical and biochemical properties of the receptors by modifying the characteristics of the iron oxide nanoparticles.[12] [13]

History and Motivation

Epilepsy is a common chronic set of neurological disorders which are characterized by seizures and affect over 50 million people or 0.4% - 1% of the global population. Currently, there is a basic understanding of the pathophysiology and there exists treatments including medication, surgery, and dieting. While these treatments are effective for many people, there are still approximately 20% - 30% of patients who don't have access to medication or have developed a resistance to antiepileptic drugs. As such, many people are left without any treatment options providing an strong need for the development of innovative methods for treating epilepsy.

In recent studies, gene therapy has provided increasingly significant advances in the treatment of a wide range of diseases in animal and pre-clinical trials. Through the use of viral vector gene transfer with the purpose of delivering DNA to targets for treatment, multiple vectors have proven to be to be efficient. Among those are adenovirus and adeno-associated virus vector which have properties of high efficient transduction, ease of production in high volumes, a wide host range, and extended gene expression.

• basic overview of clinical progress in Gene Therapy in terms of Epilepsy.
• Given the ineffectiveness of current medications and treatments for 20-30% of the population, there has been an increased drive towards the development of alternative therapies such as Stem Cell and Gene based therapies.

External Links

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