USP40

USP40
Identifiers
Aliases	USP40, ubiquitin specific peptidase 40
External IDs	OMIM: 610570; MGI: 2443184; HomoloGene: 32400; GeneCards: USP40; OMA:USP40 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q37.1 Start 233,475,520 bp End 233,566,782 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 D Start 87,945,119 bp End 88,008,551 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of thyroid gland left lobe of thyroid gland right uterine tube right adrenal cortex Achilles tendon C1 segment sural nerve left ovary skin of abdomen left adrenal gland Top expressed in hand genital tubercle tail of embryo ventricular zone spermatocyte lens Rostral migratory stream fossa condyle transitional epithelium of urinary bladder More reference expression data BioGPS More reference expression data
Gene ontology Molecular function thiol-dependent deubiquitinase peptidase activity cysteine-type peptidase activity hydrolase activity cysteine-type endopeptidase activity Cellular component cytoplasm nucleus cytosol Biological process protein deubiquitination ubiquitin-dependent protein catabolic process proteolysis regulation of protein stability Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55230 227334 Ensembl ENSG00000085982 ENSMUSG00000005501 UniProt Q9NVE5 Q8BWR4 RefSeq (mRNA) NM_018218 NM_001365479 NM_001033291 NM_001198573 RefSeq (protein) NP_060688 NP_001352408 NP_001369224 NP_001369225 NP_001369226 NP_001369227 NP_001369228 NP_001369229 NP_001369230 NP_001369231 NP_001369232 NP_001028463 NP_001185502 Location (UCSC) Chr 2: 233.48 – 233.57 Mb Chr 1: 87.95 – 88.01 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Ubiquitin carboxyl-terminal hydrolase 40 is an enzyme that in humans is encoded by the USP40 gene.

Further reading

• Bass BL (2002). "RNA editing by adenosine deaminases that act on RNA". Annu. Rev. Biochem. 71 (1): 817–46. doi:10.1146/annurev.biochem.71.110601.135501. PMC 1823043. PMID 12045112.
• Chen X, Zhang Y, Douglas L, Zhou P (2002). "UV-damaged DNA-binding proteins are targets of CUL-4A-mediated ubiquitination and degradation". J. Biol. Chem. 276 (51): 48175–82. doi:10.1074/jbc.M106808200. PMID 11673459.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Quesada V, Díaz-Perales A, Gutiérrez-Fernández A, et al. (2004). "Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases". Biochem. Biophys. Res. Commun. 314 (1): 54–62. doi:10.1016/j.bbrc.2003.12.050. PMID 14715245.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
• Li Y, Schrodi S, Rowland C, et al. (2006). "Genetic evidence for ubiquitin-specific proteases USP24 and USP40 as candidate genes for late-onset Parkinson disease". Hum. Mutat. 27 (10): 1017–23. doi:10.1002/humu.20382. PMID 16917932. S2CID 43881832.