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U1A polyadenylation inhibition element (PIE)

From Wikipedia, the free encyclopedia
U1A polyadenylation inhibition element (PIE)
Identifiers
SymbolU1A_PIE
RfamRF00460
Other data
RNA typeCis-reg
Domain(s)Eukaryota
SOSO:0005836
PDB structuresPDBe

The U1A polyadenylation inhibition element (PIE) is an RNA element which is responsible for the regulation of the length of the polyA tail of the U1A protein pre-mRNA. The PIE is located in the U1A mRNA 3' UTR. PIE adopts a U-shaped structure, with binding sites for a single U1A protein at each bend and when complexed with the two proteins it blocks activity of poly(A) polymerase (PAP), and inhibits its activity.[1][2]

References

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  1. ^ Clerte C, Hall KB (October 2004). "Global and local dynamics of the U1A polyadenylation inhibition element (PIE) RNA and PIE RNA-U1A complexes". Biochemistry. 43 (42): 13404–13415. doi:10.1021/bi049117g. PMID 15491147.
  2. ^ Varani L, Gunderson SI, Mattaj IW, Kay LE, Neuhaus D, Varani G (April 2000). "The NMR structure of the 38 kDa U1A protein - PIE RNA complex reveals the basis of cooperativity in regulation of polyadenylation by human U1A protein". Nature Structural Biology. 7 (4): 329–335. doi:10.1038/74101. PMID 10742179. S2CID 13432764.
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