Tripartite motif containing 34

TRIM34
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2EGP
Identifiers
Aliases	TRIM34, IFP1, RNF21, tripartite motif containing 34
External IDs	OMIM: 605684; HomoloGene: 136478; GeneCards: TRIM34; OMA:TRIM34 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	5,644,398 bp
RNA expression pattern
	Top expressed in
	monocyte; ; lymph node; ; blood; ; spleen; ; placenta; ; granulocyte; ; appendix; ; right adrenal gland; ; right adrenal cortex; ; rectum;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	zinc ion binding; metal ion binding; molecular function;
Cellular component	cytoplasm; cytosol; intracellular anatomical structure;
Biological process	protein trimerization; positive regulation of DNA-binding transcription factor activity; defense response to virus; interferon-gamma-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	53840
	n/a
	ENSG00000258659
	n/a
	Q9BYJ4
	n/a
	NM_130390; NM_001003827; NM_021616; NM_130389
	n/a
	NP_001003827; NP_067629; NP_569074
	n/a
	Wikidata
View/Edit Human

Tripartite motif containing 34 is a protein that, in humans, is encoded by the TRIM34 gene.^[3]

Function

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. Expression of this gene is up-regulated by interferon. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from the upstream TRIM6 gene has also been observed, which results in a fusion product from these neighboring family members.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000258659 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Tripartite motif containing 34". Retrieved 2016-09-01.

Function

References

Further reading