Travoprost

Travoprost

Clinical data
Pregnancy category	C US
Routes of administration	Topical (eye drops)
ATC code	S01EE04 (WHO)
Legal status
Legal status	Rx only (US)
Identifiers
IUPAC name propan-2-yl 7-[3,5-dihydroxy-2-[3-hydroxy-4-[3-(trifluoromethyl) phenoxy]-but-1-enyl]-cyclopentyl]hept-5-enoate
CAS Number	157283-68-6
PubChem CID	656627
DrugBank	APRD01271
CompTox Dashboard (EPA)	DTXSID80896948
ECHA InfoCard	100.207.141
Chemical and physical data
Formula	C26H35F3O6
Molar mass	500.548 g/mol g·mol−1
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Travoprost ophthalmic solution is a topical medication used for controlling the progression of glaucoma or ocular hypertension, by reducing intraocular pressure. It is a prostaglandin analogue that works by increasing the outflow of aqueous fluid from the eyes. It is also known by the brand name of Travatan and Travatan Z, manufactured by Alcon Inc. Travoprost is a synthetic prostaglandin F 2α analogue. Its chemical name is isopropyl (Z)-7- [(1 R ,2 R ,3 R ,5 S )-3,5-dihydroxy-2-[(1 E ,3 R )-3-hydroxy-4-[(α,α,α-trifluoro- m -tolyl)oxy]-1- butenyl]cyclopentyl]-5-heptenoate.

Side effects

Possible side effects of this medication are:

• May cause blurred vision;
• May cause eyelid redness;
• May permanently darken eyelashes;
• May cause eye discomfort;
• May eventually cause permanent darkening of the iris to brown (heterochromia);
• May cause a temporary burning sensation during use.
• May cause thickening of the eyelashes.
• May Cause inflamation of the Prostate gland, restricting urine flow (BPH).

References

TravatanZ® (manufacturer’s website)

• http://www.nlm.nih.gov/medlineplus/druginfo/meds/a602027.html