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Transcription factor DP

From Wikipedia, the free encyclopedia
DP
structure of the rb c-terminal domain bound to an e2f1-dp1 heterodimer
Identifiers
SymbolDP
PfamPF08781
InterProIPR014889
PROSITEPDOC00359
MEROPSS9
SCOP21c5e / SCOPe / SUPFAM
CAZyGT1
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

In molecular biology, transcription factor DP (Dimerization Partner) is a family of proteins which function as transcription factors. DP forms a heterodimer with E2F and regulates genes involved in cell cycle progression. The transcriptional activity of E2F is inhibited by the retinoblastoma protein which binds to the E2F-DP heterodimer [1] and negatively regulates the G1-S transition.

See also

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References

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  1. ^ Rubin SM, Gall AL, Zheng N, Pavletich NP (December 2005). "Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release". Cell. 123 (6): 1093–106. doi:10.1016/j.cell.2005.09.044. PMID 16360038. S2CID 6158027.
This article incorporates text from the public domain Pfam and InterPro: IPR014889