Thomas Martin (pathologist)
Thomas John Martin | |
|---|---|
| Born | Thomas John "Jack" Martin January 24, 1937 |
| Education | University of Melbourne[1][3] Degrees: |
| Alma mater | University of Melbourne |
| Known for | Discovery of parathyroid hormone-related protein (PTHrP) |
| Scientific career | |
| Fields | |
| Institutions |
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Thomas John "Jack" Martin is an Australian pathologist, emeritus professor of medicine, physician and academic at University of Melbourne,[1][3] and researcher who, in 1987, by leading a former team of researchers at the same university, discovered a proteinaceous hormone called parathyroid hormone-related protein (PTHrP).[4][5] In September 2005, further research was conducted by the team of Dengshun Miao[6] and David Goltzman at the Calcium Research Laboratory and Department of Medicine, Royal Victoria Hospital of the McGill University Health Centre, and others.[6]
Martin is a member of Natalie A. Sims' laboratory[7] at Saint Vincent's Institute of Medical Research.[8] He works in the institute's Division of Medicine, Dentistry and Health Sciences, and his primary interest is cell biology of bones.[9]
Research career
[edit]Martin was the director of St Vincent's Institute from 1988 to 2002.[10] In September 2005, Martin found that PTHrP produced by osteoblasts is a physiological regulator of bone formation.[11]
In July 2022, Martin and his team at Natalie A. Sims' lab, after much research on mice, found that deletion of the gene that codes for a receptor protein called granulocyte colony-stimulating factor receptor (G-CSF) increases physiological dysfunction of cortical bones of mice having hyperactivated STAT3 proteins in their bone cells.[12] Cortical bone maturation depends on SOCS3-mediated suppression of interleukin-6 cytokine-induced STAT3 phosphorylation in bone cells, which form the cellular network embedded in bone matrix. They concluded that G-CSFR signaling could indirectly limit bone resorption and angiogenesis, and thereby has a major role in replacing condensed trabecular bone with lamellar bone during cortical bone formation.[12]
Awards and honours
[edit]| Year | Award |
|---|---|
| 1969 | Fellow of the Royal Australasian College of Physicians (FRACP)[1] |
| 1971 | Selwyn Smith Prize for medical research[1] |
| 1974 | Eric Susman Prize received from the Royal Australasian College of Physicians[1] |
| 1990 | Lemberg Medal received from the Australian Biochemical Society[1] |
| 1992 |
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- In August 2022, an award "TJ Martin Medal" was named in Martin's honour.[10] The medal was awarded to gastroenterologist Chamara Basnayake at St Vincent's Hospital for his research into the multidisciplinary treatment of functional gastrointestinal disorders.[10]
References
[edit]- ^ a b c d e f g h i j k l m n o p q r s Centre for Transformative Innovation, Swinburne University of Technology. "Martin, Thomas John (Jack)". Encyclopedia of Australian Science and Innovation. Archived from the original on January 1, 2023. Retrieved October 30, 2022.
- ^ "Prof T.J. (Jack) Martin". Saint Vincent's Institute. Archived from the original on October 30, 2022. Retrieved October 30, 2022.
- ^ a b Fioritti, Nathan (November 22, 2016). "Professor Emeritus Thomas John Martin AO". Faculty of Medicine, Dentistry and Health Sciences. Archived from the original on October 29, 2022. Retrieved October 30, 2022.
- ^ Martin TJ, Moseley JM, Gillespie MT (1991). "Parathyroid hormone-related protein: biochemistry and molecular biology". Critical Reviews in Biochemistry and Molecular Biology. 26 (3–4): 377–395. doi:10.3109/10409239109114073. PMID 1935171. Archived from the original on October 17, 2022. Retrieved October 29, 2022.
- ^ US patent 5460978A, Martin TJ, Moseley JM, Kemp BE, Wettenhall RE, "Protein active in humoral hypercalcemia of malignancy-PthrP", issued October 24, 1995, assigned to University of Melbourne
- ^ a b Miao, D.; He, B.; Jiang, Y.; Kobayashi, T.; Sorocéanu, M. A.; Zhao, J.; et al. (September 2005). "Osteoblast-derived PTHrP is a potent endogenous bone anabolic agent that modifies the therapeutic efficacy of administered PTH 1-34". The Journal of Clinical Investigation. 115 (9): 2402–2411. doi:10.1172/JCI24918. PMC 1193882. PMID 16138191.
- ^ Sims, Natalie A. "Natalie A Sims's Lab". ResearchGate.
- ^ Martin, Thomas J. "Thomas Martin - Saint Vincent's Institute". ResearchGate. Archived from the original on August 11, 2022. Retrieved October 29, 2022.
- ^ "Prof Thomas Martin". Find an Expert - University of Melbourne. Archived from the original on November 4, 2022. Retrieved October 29, 2022.
- ^ a b c "2022 TJ Martin Medal Award Winner". ACMD. Archived from the original on October 30, 2022. Retrieved October 30, 2022.
- ^ Martin TJ (September 2005). "Osteoblast-derived PTHrP is a physiological regulator of bone formation". The Journal of Clinical Investigation. 115 (9): 2322–2324. doi:10.1172/JCI26239. PMC 1193889. PMID 16138187.
- ^ a b Isojima, Tsuyoshi; Walker, Emma C; Poulton, Ingrid J; McGregor, Narelle E; Wicks, Ian P; Gooi, Jonathan H; Martin, T John; Sims, Natalie A (July 20, 2022). "G-CSF Receptor Deletion Amplifies Cortical Bone Dysfunction in Mice With STAT3 Hyperactivation in Osteocytes". Journal of Bone and Mineral Research. 37 (10): 1876–1890. doi:10.1002/jbmr.4654. ISSN 0884-0431.