Template:Side effects of high-dose cyproterone acetate

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Side effects of high-dose cyproterone acetate
Frequency	System Organ Class	Side effect
Very common (≥10%)	General disorders and administration site conditions	Headache Tiredness
	Psychiatric disorders	Decreased libido (men) Erectile dysfunction (men) Reduced ejaculate volume (men)
	Reproductive system and breast disorders	Reversible inhibition of spermatogenesis (men) Inhibition of ovulation and reversible infertility (women)
	Hepatobiliary disorders	Elevated liver enzymes
Common (≥1% and <10%)	Metabolism and nutrition disorders	Weight gain or loss (can be associated with fluid retention)
	Psychiatric disorders	Depressed mood Restlessness
	Reproductive system and breast disorders	Gynecomastia (men) Breast pain/tenderness Irregular menstruation
	General disorders and administration site conditions	Fatigue Hot flashes Sweating
	Respiratory, thoracic, and mediastinal disorders	Shortness of breath
	Gastrointestinal disorders	Nausea Gastrointestinal complaints
Uncommon (≥0.1% and <1%)	Psychiatric disorders	Decreased libido (women)
Uncommon (≥0.1% and <1%)	Skin and subcutaneous tissue disorders	Rash
Rare (≥0.01% and <0.1%)	Immune system disorders	Hypersensitivity reactions (rash, itching, shortness of breath)
Rare (≥0.01% and <0.1%)	Psychiatric disorders	Increased libido (women)
Very rare (<0.01%)	Neoplasms benign and malignant	Benign and malignant liver tumors
	Musculoskeletal and connective tissue disorders	Osteoporosis
	Cardiovascular disorders	Thromboembolic events Tachycardia
	Reproductive system and breast disorders	Galactorrhea
	General disorders and administration site conditions	Sleep disturbances
Unspecified	Unsorted	Anemia Meningioma Hyperprolactinemia Prolactinoma Intra-abdominal hemorrhage Breast tension Menstrual spotting Low Dysmenorrhea Vaginal discharge Skin discoloration Stretch marks Rare Liver toxicity (including jaundice, hepatitis, liver failure)
Notes: Side effects are for dosages of cyproterone acetate (Androcur) of 10 to 300 mg/day. Sources: ^[1]^[2]^[3]

[Androcur-Label-UK-1] ttps://www.medicines.org.uk/emc/files/pil.1120.pdf

[Androcur-Label-AU-2] ttp://www.bayerresources.com.au/resources/uploads/PI/file9701.pdf

[pmid15073785-3] Heinemann LA, Will-Shahab L, van Kesteren P, Gooren LJ (May 1997). "Safety of cyproterone acetate: report of active surveillance". Pharmacoepidemiol Drug Saf. 6 (3): 169–78. doi:10.1002/(SICI)1099-1557(199705)6:3<169::AID-PDS263>3.0.CO;2-3. PMID 15073785.

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[2]

[3]

Template:Side effects of high-dose cyproterone acetate

Usage

References