Jump to content

Template:Side effects of estramustine phosphate (FDA)

From Wikipedia, the free encyclopedia
Side effects of estramustine phosphate (FDA)
Side effect Estramustine phosphate (oral
11.5–15.9 mg/kg/day) (n = 93) (%)
Diethylstilbestrol (oral
3.0 mg/day) (n = 93) (%)
Cardiovascular and respiratory
Cardiac arrest 0 2
Cerebrovascular accident (stroke) 2 0
Myocardial infarction (heart attack) 3 1
Thrombophlebitis 3 7
Pulmonary embolism 2 5
Congestive heart failure 3 2
Edema (swelling) 19 17
Dyspnea (shortness of breath) 11 3
Leg cramps 8 11
Upper respiratory discharge 1 1
Hoarseness 1 0
Gastrointestinal
Nausea 15 8
Diarrhea 12 11
Minor gastrointestinal upset 11 6
Anorexia (appetite loss) 4 3
Flatulence 2 0
Vomiting 1 1
Gastrointestinal bleeding 1 0
Burning throat 1 0
Thirst 1 0
Integumentary
Rash 1 4
Pruritus (itching) 2 2
Dry skin 2 0
Pigment changes 0 3
Easy bruising 3 0
Flushing 1 0
Night sweats 0 1
Peeling of fingertip skin 1 0
Thinning hair 1 1
Breast changes
Breast tenderness 66 64
Breast enlargement (gynecomastia or male breast development)
  Mild 60 54
  Moderate 10 16
  Marked 0 5
Miscellaneous
Lethargy alone 4 3
Depression 0 2
Emotional lability 2 0
Insomnia 3 0
Headache 1 1
Anxiety 1 0
Chest pain 1 1
Hot flashes 0 1
Eye pain 0 1
Lacrimation (eye tears) 1 1
Tinnitus 0 1
Laboratory abnormalities
Hematologic (blood)
Leukopenia (low white blood cells) 4 2
Thrombopenia (low platelets) 1 2
Hepatic (liver)
Bilirubin alone 1 5
Bilirubin and LDHTooltip lactate dehydrogenase 0 1
Bilirubin and ASTTooltip aspartate transaminase 2 1
Bilirubin, LDH, and SGOT 2 0
LDH and/or SGOT 31 28
Miscellaneous
Transient hypercalcemia (high calcium) 0 1
Sources: [1]

References

[edit]
  1. ^ "Emcyt estramustine phosphate sodium capsules" (PDF). FDA. Retrieved 14 March 2022.