Template:Plasma estrogen levels after a single dose of conjugated estrogens by different routes
| Route | Dose | Time | E2 (↑Δ) | E1 (↑Δ) | Ratio | Ref |
|---|---|---|---|---|---|---|
| Oral |
0.3 mg 0.625 mg 1.25 mg 1.25 mg 2.5 mg |
6 hours 6 hours 6 hours 1 hour 6 hours |
+20 pg/mL +50 pg/mL +70 pg/mL +35–58 pg/mL +160 pg/mL |
ND ND ND 110 pg/mL ND |
ND ND ND 0.32–0.52 ND |
[1] [1] [1] [2] [1] |
| Vaginal (cream) |
0.3 mg 0.625 mg 0.625 mg 1.25 mg 1.25 mg 2.5 mg |
ND ND ND 2 hours ND ND |
+4 pg/mL +13–29 pg/mL +17 pg/mL +25 pg/mL +27 pg/mL +32 pg/mL |
+20 pg/mL +29–55 pg/mL +45 pg/mL +50 pg/mL +110 pg/mL +40 pg/mL |
0.2 0.24–1.0 0.38 0.5 0.25 0.8 |
[3] [4] [3] [5] [3] [3] |
| Intravenousa | 20 mg | 5 min 30 min 60 min 120 min |
800 pg/mL 3000 pg/mL 3500 pg/mL 3100 pg/mL |
4500 pg/mL 24000 pg/mL 19000 pg/mL 10500 pg/mL |
1:5.3 1:8.1 1:5.5 1:3.4 |
[6] [6] [6] [6] |
| Notes: a = Absolute levels, not change. Sources: [7] | ||||||
References
[edit]- ^ a b c d Utian WH, Katz M, Davey DA, Carr PJ (October 1978). "Effect of premenopausal castration and incremental dosages of conjugated equine estrogens on plasma follicle-stimulating hormone, luteinizing hormone, and estradiol". Am. J. Obstet. Gynecol. 132 (3): 297–302. PMID 212949.
- ^ Whittaker PG, Morgan MR, Dean PD, Cameron EH, Lind T (January 1980). "Serum equilin, oestrone, and oestradiol levels in postmenopausal women receiving conjugated equine oestrogens ('Premarin')". Lancet. 1 (8158): 14–6. doi:10.1016/s0140-6736(80)90552-8. PMID 6101354.
- ^ a b c d Mandel FP, Geola FL, Meldrum DR, Lu JH, Eggena P, Sambhi MP, Hershman JM, Judd HL (July 1983). "Biological effects of various doses of vaginally administered conjugated equine estrogens in postmenopausal women". J. Clin. Endocrinol. Metab. 57 (1): 133–9. doi:10.1210/jcem-57-1-133. PMID 6304131.
- ^ Hage, J. C., & Jaszmann, L. B. (1983). A Study of the Effects of Premarin Cream in the Post-Menopausal Woman. Current Therapeutic Research-Clinical and Experimental, 33(6), 925-929.
- ^ Rigg LA, Hermann H, Yen SS (January 1978). "Absorption of estrogens from vaginal creams". N. Engl. J. Med. 298 (4): 195–7. doi:10.1056/NEJM197801262980406. PMID 201842.
- ^ a b c d Honjo H, Kitawaki J, Itoh M, Yasuda J, Iwasaku K, Urabe M, Naitoh K, Yamamoto T, Okada H, Ohkubo T (1987). "Serum and urinary estrone sulfate during the menstrual cycle, measured by a direct radioimmunoassay, and fate of exogenously injected estrone sulfate". Horm Res. 27 (2): 61–8. doi:10.1159/000180788. PMID 3653846.
- ^ Nichols KC, Schenkel L, Benson H (1984). "17 beta-estradiol for postmenopausal estrogen replacement therapy". Obstet Gynecol Surv. 39 (4): 230–45. doi:10.1097/00006254-198404000-00022. PMID 6717863.