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COVID‑19 vaccine candidates in Phase I–III trials[1][2][3]
()
Vaccine candidates,
developers, and sponsors
Country of origin Type (technology) Current phase (participants)
design
Completed phase[a] (participants)
Immune response
Pending authorization
Sanofi–GSK COVID-19 vaccine (VAT00008, Vidprevtyn)
Sanofi Pasteur, GSK
France, United Kingdom Subunit (SARS-CoV-2 S adjuvanted recombinant protein) Phase III (37,430)[4][5]
A Parallel-group, Phase III, Multi-stage, Modified Double-blind, Multi-armed Study to Assess the Efficacy, Safety, and Immunogenicity of Two SARS-CoV-2 Adjuvanted Recombinant Protein Vaccines (Monovalent and Bivalent) for Prevention Against COVID-19 in Adults 18 Years of Age and Older.
May 2021 – Mar 2023, Colombia, Dominican Republic, Ghana, Honduras, India (3,000), Japan, Kenya,[6] Mexico,[7] Nigeria, Pakistan, Sri Lanka, Uganda, United States
Phase I–II (1,160)
Phase I-IIa (440): Immunogenicity and Safety of SARS-CoV-2 Recombinant Protein Vaccine Formulations (With or Without Adjuvant) in Healthy Adults 18 Years of Age and Older.[8]
Phase IIb (720): Immunogenicity and Safety of SARS-CoV-2 Recombinant Protein Vaccine With AS03 Adjuvant in Adults 18 Years of Age and Older.[9]
Sep 2020 – Apr 2022, United States
Emergency (5)
Nanocovax[16]
Nanogen Pharmaceutical Biotechnology JSC
Vietnam Subunit (SARS‑CoV‑2 recombinant spike protein with aluminum adjuvant)[17][18] Phase III (13,000)[19][20]
Adaptive, multicenter, randomized, double-blind, placebo-controlled
Jun 2021 – Jul 2022, Vietnam
Phase I–II (620)[21]
Phase I (60): Open label, dose escalation.
Phase II (560): Randomization, double-blind, multicenter, placebo-controlled.
Dec 2020 – Jun 2021, Vietnam
Emergency (1)
UB-612
United Biomedical,Inc, Vaxxinity, DASA
Brazil, Taiwan, United States Subunit (Multitope peptide based S1-RBD-protein based vaccine) Phase III (18,320)[23][24]
Phase IIb/III (7,320): Randomized, Multicenter, Double-Blind, Placebo Controlled, Dose-Response.
Phase III (11,000)
Jan 2021 – Mar 2023, Taiwan (phase 2b/3), India (phase 3)[25]
Phase I–II (3,910)[26]
Phase 1 (60): Open-label study
Phase IIa (3,850): Placebo-controlled, Randomized, Observer-blind Study.
Sep 2020 – Jan 2021, Taiwan
Emergency (1)
SCB-2019[28][29]
Clover Biopharmaceuticals,[30][31] Dynavax Technologies,[32] CEPI
China Subunit (spike protein trimeric subunit with combined CpG 1018 and aluminium adjuvant) Phase III (30,300)
Phase II/III (30,000): Randomized, double-blind, controlled.
Phase III (300): Double-blind, randomized, controlled.[33]
Mar 2021 – Oct 2022, Belgium, Brazil, Colombia, Dominican Republic, Germany, Nepal, Panama, the Philippines, Poland, South Africa, Ukraine
Phase I–II (950)
Phase I (150): Randomized, Double-blind, Placebo-controlled, First-in-human.
Phase II (800): Multi-center, Double-blind, Randomized, Controlled.[34]
Jun 2020 – Oct 2021, Australia (phase 1), China (phase 2)
Emergency (1)
S-268019
Shionogi
Japan Subunit Phase III (54,915)[35][36]
Phase II/III: Open-label.
Phase III: Randomized, observer-blind, placebo-controlled cross-over.
Oct 2021 – Dec 2022, Japan (3,100), Vietnam
Phase I–II (300)[37]
Randomized, double-blind, placebo-controlled, parallel-group.
Dec 2020 – Aug 2021, Japan
West China Hospital COVID-19 vaccine
Jiangsu Province Centers for Disease Control and Prevention, West China Hospital (WestVac Biopharma), Sichuan University
China Subunit (recombinant with Sf9 cell) Phase III (40,000)[38]
Multicenter, randomized, double-blind, placebo-controlled.
Jun 2021 – Feb 2022, Indonesia, Kenya, Malaysia,[39] Mexico, Nepal, the Philippines (5,000)[40]
Phase I–II (5,128)[41][42][43]
Phase I (168): Single-center, Randomized, Placebo-controlled, Double-blind.
Phase IIa (960):Single-center, Randomized, Double-Blinded, Placebo-Controlled.
Phase IIb (4,000):Single-center, Randomized, Double-Blinded, Placebo-Controlled.
Aug 2020 – May 2021, China
DelNS1-2019-nCoV-RBD-OPT (DelNS1-nCoV-RBD LAIV)
Beijing Wantai Biological Pharmacy, University of Hong Kong, Xiamen University
China, Hong Kong Replicating viral vector (flu-based-RBD[clarification needed]) Phase III (40,000)[44]
Multi-center, Randomized, Double-blind, Placebo controlled.
Oct 2021 – Apr 2022, the Philippines
Phase I–II (895)[45][46]
Phase I (60+115=175)
Phase II (720)
Sep 2020 – Sep 2022, China (60), Hong Kong (115)
Versamune-CoV-2FC [pt]
Farmacore Biotechnology, PDS Biotechnology Corporation, Faculty of Medicine of Ribeirão Preto
Brazil, United States Subunit Phase III (30,000)[47]
Double-blind, randomized controlled.
Aug–Dec 2021, Brazil
Phase I–II (360)[48][49][50]
Double-blind, randomized controlled.
Mar–Aug 2021, Brazil
Walvax COVID-19 vaccine (ARCoV)[51]
PLA Academy of Military Science, Walvax Biotech,[52] Suzhou Abogen Biosciences
China RNA Phase III (28,000)[53]
Multi-center, Randomized, Double-blind, Placebo-controlled
May–Nov 2021, China,[54] Colombia, Indonesia, Malaysia, Mexico, Nepal, Pakistan, the Philippines, Turkey
Phase I–II (908)
Phase I (168)
Phase II (420)
Phase I/II (320)[55]
Jun 2020 – Oct 2021, China[56]
V-01
Livzon Mabpharm, Inc.
China Subunit (SARS-CoV-2 recombinant fusion protein) Phase III (22,500)[57]
Global, multi-center, randomized, double-blind, placebo-controlled.
Aug 2021–Mar 2023, the Philippines
Phase I (1,060)[58][59]
Phase I (180): Single-center, randomized, double-blind and placebo-controlled.
Phase II (880): Randomized, double-blind, and placebo-controlled.
Feb–May 2021, China
ARCT-154 (VBC-COV19-154 in Vietnam)[60][61][62]
Arcturus Therapeutics, Vinbiocare
United States, Vietnam RNA Phase III (20,600)
Phase IIIa (600): Randomized, double-blinded, placebo controlled.
Phase IIIb (20,000): Randomized, double-blinded, placebo controlled.[63][64]
Oct-Dec 2021, Vietnam
Phase I–II (400)
Phase I (100): Randomized, double-blinded, placebo controlled.
Phase II (300): Randomized, double-blinded, placebo controlled.
Aug-Oct 2021, Vietnam[65]
ReCOV
Jiangsu Rec-Biotechnology Co Ltd
China Subunit (Recombinant two-component spike and RBD protein (CHO cell)) Phase II–III (20,301)[66]
Multi-center, randomized, double-blind, placebo-controlled.
Dec 2021–Dec 2022, China, New Zealand, the Philippines
Phase I (160)[67]
First-in-human, randomized, double-blind, placebo-controlled, dose-finding.
Jun–Dec 2021, New Zealand
BriLife (IIBR-100)[68]
The Israel Institute for Biological Research
Israel Vesicular stomatitis vector (recombinant) Phase III (20,000)[69]
Randomized, multi-center, placebo-controlled.
Sept – Dec 2021, Israel
Phase I–II (1,040)[70]
Randomized, multi-center, placebo-controlled, dose-escalation.
Oct 2020 – May 2021, Israel
Zhongyianke Biotech–Liaoning Maokangyuan Biotech COVID-19 vaccine
Zhongyianke Biotech, Liaoning Maokangyuan Biotech, Academy of Military Medical Sciences
China Subunit (Recombinant) Phase III (14,600)[71]
International multicenter, randomized, double-blind, placebo-controlled.
Sep 2021–?, China
Phase I–II (696)[72]
Phase I (216): Randomized, placebo-controlled, double-blind.
Phase II (480): Single-center, randomized, double blinded, placebo controlled.[73]
Oct 2020 – Jul 2021, China
GX-19 (GX-19N)[74][75][76]
Genexine consortium,[77][78] International Vaccine Institute
South Korea DNA Phase II–III (14,000)[79]
Randomized, double-blinded, placebo-controlled.
Oct 2021 – Oct 2022, Indonesia, Seoul
Phase I–II (410)
Phase I-II (170+210+30): Multi-center, some open-labeled, some double-blinded, single arm, randomized, placebo-controlled
Jun 2020 – Jul 2021, Seoul
GRAd-COV2[80][81]
ReiThera, Lazzaro Spallanzani National Institute for Infectious Diseases
Italy Adenovirus vector (modified gorilla adenovirus vector, GRAd) Phase III (10,300)[82][83]
Randomized, stratified, observer-blind, placebo-controlled.
Mar–Oct 2021, Italy
Phase I (90)[84]
Subjects (two groups: 18–55 and 65–85 years old) randomly receiving one of three escalating doses of GRAd-COV2 or a placebo, then monitored over a 24-week period. 93% of subjects who received GRAd-COV2 developed anti-bodies.
Aug–Dec 2020, Rome
Inovio COVID-19 Vaccine (INO-4800)[85][86]
Inovio, CEPI, Korea National Institute of Health, International Vaccine Institute
South Korea, United States DNA vaccine (plasmid delivered by electroporation) Phase III (7,517)
Randomized, placebo-controlled, multi-center.[87]
Nov 2020 – Jan 2023, Brazil, Colombia, Mexico, the Philippines, United States[b]
Phase I–II (920)
Phase Ia (120): Open-label trial.
Phase Ib-IIa (160): Dose-Ranging Trial.[88]
Phase II (640): Randomized, double-blinded, placebo-controlled, dose-finding.[89]
April 2020 – Feb 2022, China (phase II), South Korea (phase Ib-IIa), United States
DS-5670[90]
Daiichi Sankyo[91]
Japan RNA Phase II–III (5,028)[92]
Randomized, Active-comparator, Observer-blind.
Dec 2021 – Jul 2023, Japan
Phase I–II (152)[93]
A Phase 1/2 Study to Assess the Safety, Immunogenicity and Recommended Dose of DS-5670a (COVID-19 Vaccine) in Japanese Healthy Adults and Elderly Subjects.
Mar 2021 – Jul 2022, Japan
GBP510
SK Bioscience Co. Ltd., GSK
South Korea, United Kingdom Subunit (Recombinant protein nanoparticle with adjuvanted with AS03) Phase III (4,000)[94]
Randomized, active-controlled, observer-blind, parallel-group, multi-center.[95]
Aug 2021-Mar 2022, South Korea
Phase I–II (580)[96][97]
Phase I-II (260-320): Placebo-controlled, randomized, observer-blinded, dose-finding.
Jan–Aug 2021, South Korea
HGC019[98]
Gennova Biopharmaceuticals, HDT Biotech Corporation[99]
India, United States RNA Phase II–III (4,400)[100]
A prospective, multicentre, randomized, active-controlled (with COVISHIELD), observer-blind study to evaluate safety, tolerability and immunogenicity in healthy adults.
Phase II (400)
Phase III (4,000)
Sep 2021 – Sep 2022, India
Phase I–II (620)[101][102][103]
Randomized, phase I/II, placebo-controlled, dose-ranging, parallel-group, crossover, multi-centre study to evaluate the safety, tolerability and immunogenicity in healthy adult subjects.
Phase I (120) open-label study in healthy 18-70 year-olds.
Phase II (500) observer-blind study in healthy 18-75 year-olds.
Apr 2021 – Oct 2021, India
KD-414
KM Biologics Co
Japan Inactivated SARS‑CoV‑2 Phase II–III (2,000)[104]
Multicenter, open-label, non-randomized.
Oct 2021 – Mar 2023, Japan
Phase I–II (210)[105]
Randomized, double blind, placebo control, parallel group.[106]
Mar 2021 – Dec 2022, Japan
LYB001
Yantai Patronus Biotech Co., Ltd[107]
China Virus-like particle[108] Phase II–III (1,900)[109]
Phase II: Randomized, double blinded, placebo-controlled
Phase III: Single-armed, open-label expanded.
Jan 2022 – Mar 2023, Laos
Phase I (100)[110]
Randomized, double blinded, placebo-controlled.
Dec 2021 – Feb 2022, Laos
AKS-452
Akston Biosciences, University Medical Center Groningen
Netherlands Subunit Phase II–III (1,600)[111]
Randomized, double-blinded, placebo-controlled, parallel-group, multi-centre, adaptive, seamless bridging.
Oct 2021–Dec 2022, India
Phase I–II (112)[112]
Non-randomized, Single-center, open-label, combinatorial.
Apr–Sep 2021, Netherlands
AG0302-COVID‑19[113][114]
AnGes Inc.,[115] AMED
Japan DNA vaccine (plasmid) Phase II–III (500)
Randomized, double-blind, placebo controlled[116]
Nov 2020 – Apr 2021, Japan
Phase I–II (30)
Randomized/non-randomized, single-center, two doses
Jun–Nov 2020, Osaka
202-CoV
Shanghai Zerun Biotechnology Co., Ltd., Walvax Biotech
China Subunit (Spike protein (CHO cell) 202-CoV with CpG / alum adjuvant) Phase II (1,056)[117]
Randomized, Double-blinded, Placebo-controlled.
July–Dec 2021, China
Phase I (144)[118]
Randomized, double-blinded, placebo-controlled.
July–Dec 2021, China
Vaxart COVID-19 vaccine
Vaxart
United States Viral vector Phase II (896)[119]
Double-Blind, Multi-Center, Randomized, Placebo-Controlled, Dose-Ranging.
Oct 2021 – Mar 2022, United States
Phase I (83)[120][121]
Phase Ia (35): Double-blind, randomized, placebo-controlled, first-in-Human.
Phase Ib (48): Multicenter, randomized, double-blind, placebo-controlled.
Sep 2020 – Aug 2021, United States
PTX-COVID19-B[122]
Providence Therapeutics
Canada RNA Phase II (890)[123]
Randomized, double-dummy, observer-blind.
Aug 2021–Feb 2022, Canada
Phase I (60)[122]
First-in-Human, Observer-Blinded, Randomized, Placebo Controlled.[124]
Jan–May 2021, Canada
Unnamed
Ningbo Rong’an Biological Pharmaceutical Co., Ltd.
China Inactivated SARS‑CoV‑2 Phase II (600)[125]
Randomized, double-blind, placebo-controlled.
Oct 2021 – Mar 2022, China
Phase I (150)[126]
Randomized, double-blind, placebo-controlled.
Aug – Oct 2021, China
Unnamed
Tsinghua University, Tianjin Medical University,[127] Walvax Biotech
China Viral vector Phase II (360)[128]
Jul–Nov 2021, China
Phase I (60)[129]
May–Jun 2021, China
INNA-051
Ena Respiratory
Australia Viral vector Phase II (423)[130]
Randomized, double-blind, placebo-controlled.
Mar  – Dec 2022, Australia
Phase I (124)[131]
Randomised, double blind, placebo-controlled.
Jun – Oct 2021, Australia
mRNA-1283
Moderna
United States RNA Phase II (420)[132]
Randomized, stratified, observer-blind.
Dec 2021 – Jan 2023, United States
Phase I (106)[133]
Randomized, observer-blind, dose-ranging study.
Mar 2021 – Apr 2022, United States
Unnamed
Ihsan Gursel, Scientific and Technological Research Council of Turkey
Turkey Virus-like particle Phase II (330)[134]
Randomized, parallel dose assigned, double blind, multi center.
Jun – Sep 2021, Turkey
Phase I (36)[135]
double-blinded, randomised, placebo controlled.
Mar – May 2021, Turkey
COH04S1
GeoVax, City of Hope Medical Center
United States Viral vector Phase II (240)[136]
Multi-center, observer-blinded, EUA vaccine-controlled, randomized.
Aug 2021 – Jun 2023, California
Phase I (129)[137]
Dose Escalation Study.
Dec 2020 – Nov 2022, California
ABNCoV2
Bavarian Nordic.[138] Radboud University Nijmegen
Denmark, Netherlands Virus-like particle Phase II (210)[139][140]
Single center, sequential dose-escalation, open labelled trial.
Aug–Dec 2021, Germany
Phase I (42)[141]
Single center, sequential dose-escalation, open labelled trial.
Mar–Dec 2021, Netherlands
SCB-2020S
Clover Biopharmaceuticals[142]
China Subunit Phase I–II (150)[143]
Randomized, controlled, observer-blind.
Aug 2021 – Apr 2022, Australia
Preclinical
SCTV01C
Sinocelltech
China Subunit Phase I–II (1,712)[144][145][146]
540+420+752=1,712: multicenter, randomized, double-blinded trial.
Aug 2021 – Jun 2023, China
Preclinical
NDV-HXP-S (ButanVac, COVIVAC, HXP-GPOVac, Patria)
Icahn School of Medicine at Mount Sinai, Institute of Vaccines and Medical Biologicals,[147] Butantan Institute, Laboratorio Avimex, National Council of Science and Technology, Mahidol University, University of Texas at Austin
Brazil, Mexico, Thailand, United States, Vietnam Newcastle disease virus (NDV) vector (expressing the spike protein of SARS-CoV-2, with or without the adjuvant CpG 1018)/Inactivated SARS‑CoV‑2 Phase I–II (12,750)
Randomized, placebo-controlled, observer-blind.
Mar 2021 – May 2022; Brazil (5,394), Mexico (Phase I: 90, Phase II: 396),[148] Thailand (460),[149] United States (Phase I: 35),[150] Vietnam (495)[151][152]
Preclinical
Stemirna COVID-19 vaccine
Stemirna Therapeutics Co. Ltd.
China RNA Phase I–II (880)[153][154]
Phase I (240): Randomized, double-blind, placebo-controlled.
Phase I/II (640): Open-label.
Mar 2021–Feb 2022, China (phase I), Lao (phase I/II)
Preclinical
ARCT-021[155][156]
Arcturus Therapeutics, Duke–NUS Medical School
United States, Singapore RNA Phase I–II (798)
Phase I/II (92): Randomized, double-blinded, placebo controlled
Phase II (600): Randomized, observer-blind, placebo-controlled, multiregional, multicenter trial in healthy adults to evaluate the safety, reactogenicity, and immunogenicity.[157]
Phase IIa (106): Open label extension trial to assess the safety and long-term immunogenicity by giving single-dose vaccine to the participants from the parent study that received placebo or were seronegative at screening.[158]
Aug 2020 – Apr 2022, Singapore, United States (phase IIa)
Preclinical
Unnamed
PT Bio Farma
Indonesia Subunit Phase I–II (780)[159]
Observer-Blind, Randomized, Controlled.
Oct 2021 – Jan 2022, Indonesia
Preclinical
VBI-2902[160]
Variation Biotechnologies
United States Virus-like particle Phase I (141)[161]
Randomized, observer-blind, dose-escalation, placebo-controlled
Mar 2021 – Nov 2022, Canada
Preclinical
ICC Vaccine[162]
Novavax
United States Subunit Phase I–II (640)[163]
Randomized, observer-blinded.
Sep 2021 – Mar 2022, Australia
Preclinical
EuCorVac-19[164]
EuBiologics Co
South Korea Subunit (spike protein using the recombinant protein technology and with an adjuvant) Phase I–II (280)
Dose-exploration, randomized, observer-blind, placebo-controlled
Feb 2021 – Mar 2022, the Philippines (phase II), South Korea (phase I/II)
Preclinical
PHH-1V
Hipra[165]
Spain Subunit Phase I–II (286)[166][167]
Phase I/IIa (30): Randomized, controlled, observer-blinded, dose-escalation.
Phase IIb (256): Randomized, controlled, observer-blinded.
Aug–Dec 2021, Spain (phase I/IIa), Vietnam (phase IIb)
Preclinical
RBD SARS-CoV-2 HBsAg VLP
SpyBiotech
United Kingdom Virus-like particle Phase I–II (280)[168]
Randomized, placebo-controlled, multi-center.
Aug 2020 – ?, Australia
Preclinical
AV-COVID-19
AIVITA Biomedical, Inc., Ministry of Health (Indonesia)
United States, Indonesia Dendritic cell vaccine (autologous dendritic cells previously loaded ex vivo with SARS-CoV-2 spike protein, with or without GM-CSF) Phase I–II (202)[169][170]
Adaptive.
Dec 2020 – Feb 2022, Indonesia (phase I), United States (phase I/II)
Preclinical
COVID-eVax
Takis Biotech
Italy DNA Phase I–II (160)[171]
Multicenter, open label.
Phase I: First-in-human, dose escalation.
Phase II: single arm or two arms, randomized, dose expansion.
Feb–Sep 2021, Italy
Preclinical
BBV154[172]
Bharat Biotech[173]
India Adenovirus vector (intranasal) Phase I–II (375)[172][174]
Phase I (175): Randomized, double-blinded, multicenter.
Phase II (200): Randomized, double blind, multicenter.[175]
Mar 2021–?, India
Preclinical
VB10.2129 and VB10.2210
Nykode Therapeutics[176][177]
Norway DNA Phase I–II (160)[178][179]
Open Label, Dose Escalation.
Oct 2021–Jun 2022, Norway
Preclinical
ChulaCov19
Chulalongkorn University
Thailand RNA Phase I–II (72)[180]
Phase 1 (72): single-center, dose-escalation, first in human study in 2 age groups: 18-55 years-old and 56-75 years-old.
Phase 2: Multi-center, observer-blinded, placebo-controlled study to assess the safety, reactogenicity, and immunogenicity in healthy adults between 18-75 years old.
May-September 2021, Thailand
Preclinical
COVID‑19/aAPC[181]
Shenzhen Genoimmune Medical Institute[182]
China Lentiviral vector (with minigene modifying aAPCs) Phase I (100)[181]
Single group, open-label study to evaluate safety and immunity.
Feb 2020 – Jul 2023, Shenzhen
Preclinical
LV-SMENP-DC[183]
Shenzhen Genoimmune Medical Institute[182]
China Lentiviral vector (with minigene modifying DCs) Phase I–II (100)[183]
Single-group, open label, multi-center study to evaluate safety and efficacy.
Mar 2020 – Jul 2023, Shenzhen
Preclinical
ImmunityBio COVID-19 vaccine (hAd5)
ImmunityBio
United States Viral vector Phase I–II (540)[184][185][186][187][188]
Phase 1/2 Study of the Safety, Reactogenicity, and Immunogenicity of a Subcutaneously- and Orally- Administered Supplemental Spike & Nucleocapsid-targeted COVID-19 Vaccine to Enhance T Cell Based Immunogenicity in Participants Who Have Already Received Prime + Boost Vaccines Authorized For Emergency Use.
Oct 2020  – Sep 2021, South Africa, United States
Preclinical
COVAC[189]
VIDO (University of Saskatchewan)
Canada Subunit (spike protein + SWE adjuvant) Phase I (120)[189]
Randomized, observer-blind, dose-escalation.[190][191]
Feb 2021 – Apr 2023, Brazil Halifax
Preclinical
COVI-VAC (CDX-005)[192]
Codagenix Inc.
United States Attenuated Phase I (48)[193]
First-in-human, randomised, double-blind, placebo-controlled, dose-escalation
Dec 2020 – Jun 2021, United Kingdom
Preclinical
CoV2 SAM (LNP)
GSK
United Kingdom RNA Phase I (40)[194]
Open-label, dose escalation, non-randomized
Feb–Jun 2021, United States
Preclinical
COVIGEN[195]
Bionet Asia, Technovalia, University of Sydney
Australia, Thailand DNA Phase I (150)[196]
Double-blind, dose-ranging, randomised, placebo-controlled.
Feb 2021 – Jun 2022, Australia, Thailand
Preclinical
MV-014-212[197]
Meissa Vaccine Inc.
United States Attenuated Phase I (130)[198]
Randomized, double-blinded, multicenter.
Mar 2021 – Oct 2022, United States
Preclinical
KBP-201
Kentucky Bioprocessing
United States Subunit Phase I–II (180)[199]
First-in-human, observer-blinded, randomized, placebo-controlled, parallel group
Dec 2020 – May 2022, United States
Preclinical
AdCLD-CoV19
Cellid Co
South Korea Viral vector Phase I–II (150)[200]
Phase I: Dose Escalation, Single Center, Open.
Phase IIa: Multicenter, Randomized, Open.
Dec 2020 – Jul 2021, South Korea
Preclinical
AdimrSC-2f
Adimmune Corporation
Taiwan Subunit (Recombinant RBD +/− Aluminium) Phase I–II (310)[201][202]
Phase I (70): Randomized, single center, open-label, dose-finding.
Phase I/II (240): Placebo-controlled, randomized, double-blind, dose-finding.
Aug 2020–Sep 2022, Indonesia (phase I/II), Taiwan (phase I)
Preclinical
GLS-5310
GeneOne Life Science Inc.
South Korea DNA Phase I–II (345)[203]
Multicenter, Randomized, Combined Phase I Dose-escalation and Phase IIa Double-blind.
Dec 2020 – Jul 2022, South Korea
Preclinical
Covigenix VAX-001
Entos Pharmaceuticals Inc.
Canada DNA Phase I–II (72)[204]
Placebo-controlled, randomized, observer-blind, dose ranging adaptive.
Mar–Aug 2021, Canada
Preclinical
NBP2001
SK Bioscience Co. Ltd.
South Korea Subunit (Recombinant protein with adjuvanted with alum) Phase I (50)[205]
Placebo-controlled, Randomized, Observer-blinded, Dose-escalation.
Dec 2020 – Apr 2021, South Korea
Preclinical
CoVAC-1
University of Tübingen
Germany Subunit (Peptide) Phase I–II (104)[206][207]
Phase I (36): Placebo-controlled, Randomized, Observer-blinded, Dose-escalation.
Phase I/II (68): B-pVAC-SARS-CoV-2: Phase I/II Multicenter Safety and Immunogenicity Trial of Multi-peptide Vaccination to Prevent COVID-19 Infection in Adults With Bcell/ Antibody Deficiency.
Nov 2020 – Feb 2022, Germany
Preclinical
bacTRL-Spike
Symvivo
Canada DNA Phase I (24)[208]
Randomized, observer-blind, placebo-controlled.
Nov 2020 – Feb 2022, Australia
Preclinical
ChAdV68-S (SAM-LNP-S)
NIAID, Gritstone Oncology
United States Viral vector Phase I (150)[209]
Open-label, dose and age escalation, parallel design.
Mar 2021 – Sep 2022, United States
Preclinical
SpFN COVID-19 vaccine
WRAIR's Emerging Infectious Diseases Branch (EIDB)
United States Subunit Phase I (72)[210]
Randomized, double-blind, placebo-controlled.
Apr 2021 – Oct 2022, United States
Preclinical
MVA-SARS-2-S (MVA-SARS-2-ST)
University Medical Center Hamburg-Eppendorf
Germany Viral vector Phase I–II (270)[211][212]
Phase I (30): Open, Single-center.
Phase Ib/IIa (240): Multi-center, Randomized Controlled.
Oct 2020 – Mar 2022, Germany
Preclinical
Koçak-19 Inaktif Adjuvanlı COVID-19 vaccine
Kocak Farma
Turkey Inactivated SARS‑CoV‑2 Phase I (38)[213]
Phase 1 Study for the Determination of Safety and Immunogenicity of Different Strengths of Koçak-19 Inaktif Adjuvanlı COVID-19 Vaccine, Given Twice Intramuscularly to Healthy Volunteers, in a Placebo Controlled Study Design.
Mar–Jun 2021, Turkey
Preclinical
CoV2-OGEN1
Syneos Health, US Specialty Formulations
United States Subunit Phase I (45)[214]
First-In-Human
Jun–Dec 2021, New Zealand
Preclinical
CoVepiT
OSE Immunotherapeutics
France Subunit Phase I (48)[215][216]
Randomized, open label.
Apr–Sept 2021, France
Preclinical
HDT-301[217] (QTP104)
HDT Biotech Corporation, Senai Cimatec, Quartis[218]
Brazil, South Korea, United States RNA Phase I (189)[219][220]
Phase I (90+63+36): Randomized, open-label, dose-escalation.
Aug 2021–Jul 2023, Brazil, South Korea, United States
Preclinical
SC-Ad6-1
Tetherex Pharmaceuticals
United States Viral vector Phase I (40)[221]
First-In-Human, Open-label, Single Ascending Dose and Multidose.
Jun–Dec 2021, Australia
Preclinical
Unnamed
Osman ERGANIS, Scientific and Technological Research Council of Turkey
Turkey Inactivated SARS‑CoV‑2 Phase I (50)[222]
Phase I Study Evaluating the Safety and Efficacy of the Protective Adjuvanted Inactivated Vaccine Developed Against SARS-CoV-2 in Healthy Participants, Administered as Two Injections Subcutaneously in Two Different Dosages.
Apr–Oct 2021, Turkey
Preclinical
EXG-5003
Elixirgen Therapeutics, Fujita Health University
Japan, United States RNA Phase I–II (60)[223]
First in Human, randomized, placebo-controlled.
Apr 2021 – Jan 2023, Japan
Preclinical
IVX-411
Icosavax, Seqirus Inc.
United States Virus-like particle Phase I–II (168)[224][225]
Phase I/II (84): Randomized, observer-blinded, placebo-controlled.
Jun 2021–2022, Australia
Preclinical
QazCoVac-P[226]
Research Institute for Biological Safety Problems
Kazakhstan Subunit Phase I–II (244)[227]
Phase I: Randomized, blind, placebo-controlled.
Phase II: Randomized, open phase.
Jun – Dec 2021, Kazakhstan
Preclinical
LNP-nCOV saRNA-02
MRC/UVRI & LSHTM Uganda Research Unit
Uganda RNA Phase I (42)[228]
A Clinical Trial to Assess the Safety and Immunogenicity of LNP-nCOV saRNA-02, a Self-amplifying Ribonucleic Acid (saRNA) Vaccine, in SARS-CoV-2 Seronegative and Seropositive Uganda Population.
Sep 2021 – Jun 2022, Uganda
Preclinical
Baiya SARS-CoV-2 Vax 1[229]
Baiya Phytopharm Co Ltd.
Thailand Plant-based Subunit (RBD-Fc + adjuvant) Phase I (96)[230]
Randomized, open-label, dose-finding.
Sep–Dec 2021, Thailand
Preclinical
CVXGA1
CyanVac LLC
United States Viral vector Phase I (80)[231]
Open-label
July–Dec 2021, United States
Preclinical
Unnamed
St. Petersburg Scientific Research Institute of Vaccines and Sera of Russia at the Federal Medical Biological Agency
Russia Subunit (Recombinant) Phase I–II (200)[232][233]
Jul–Aug 2021, Russia
Preclinical
LVRNA009
Liverna Therapeutics Inc.
China RNA Phase I (24)[234]
July–Nov 2021, China
Preclinical
ARCT-165
Arcturus Therapeutics
United States RNA Phase I–II (72)[235]
Randomized, observer-blind.
Aug 2021–Mar 2023, Singapore, United States
Preclinical
BCD-250
Biocad
Russia Viral vector Phase I–II (160)[236]
Randomized, double-blind, placebo-controlled, adaptive, seamless phase I/II.
Aug 2021–Aug 2022, Russia
Preclinical
COVID-19-EDV
EnGeneIC
Australia Viral vector Phase I (18)[237]
Open label, non-randomised, dose escalation.
Aug 2021–Jan 2022, Australia
Preclinical
COVIDITY
Scancell
United Kingdom DNA[238] Phase I (40)[239]
Open-label, two-arm.
Sep 2021–Apr 2022, South Africa
Preclinical
SII Vaccine
Novavax
United States Subunit Phase I–II (240)[240]
randomized, observer-blinded, open-label.
Oct–Nov 2021, Australia
Preclinical
EG-COVID
Eyegene
South Korea mRNA Phase I–II (120)[241][242][243]
Phase I/IIa: Multi-center, Open-label.
Feb 2022–May 2023, South Korea
Preclinical
PIKA COVID-19 vaccine
Yisheng Biopharma
China Subunit Phase I (45)[244]
Open-label, dose-escalation.
Sep–Nov 2021, New Zealand
Preclinical
Ad5-triCoV/Mac
McMaster University, Canadian Institutes of Health Research (CIHR)
Canada Viral vector Phase I (30)[245]
Open-label.
Nov 2021–Jun 2023, Canada
Preclinical
Unnamed
University of Hong Kong, Immuno Cure 3 Limited
Hong Kong DNA Phase I (30)[246]
Randomized, double-blinded, placebo-controlled, dose-escalation.
Nov 2021–Jun 2022, Hong Kong
Preclinical
MigVax-101
Oravax Medical[247][248][249]
Israel Virus-like particle Phase I
Oct 2021–?, South Africa
Preclinical
IN-B009
HK inno.N[250]
South Korea Subunit (Recombinant protein) Phase I (40)[251]
Open-label, dose-escalation.
Sep 2021–Feb 2023, South Korea
Preclinical
naNO-COVID
Emergex Vaccines
United Kingdom Subunit Phase I (26)[252]
Double-blind, randomized, vehicle-controlled, dose-finding.
Nov 2021–Sep 2022, Switzerland
Preclinical
Betuvax-CoV-2
Human Stem Cells Institute
Russia Subunit Phase I–II (170)[253][254]
Sep 2021–?, Russia
Preclinical
Covi Vax[255]
National Research Centre
Egypt Inactivated SARS‑CoV‑2 Phase I (72)[256]
Randomized, open-labeled
Nov 2021–Feb 2023, Egypt
Preclinical
VLPCOV-01
VLP Therapeutics
United States mRNA Phase I (45)[257]
Randomized, placebo-controlled, parallel group, first-in-human.
Aug 2021–Jan 2023, Japan
Preclinical
GRT-R910
Gritstone Oncology
United States mRNA Phase I (120)[258]
A Phase 1 Trial to Evaluate the Safety, Immunogenicity, and Reactogenicity of a Self-Amplifying mRNA Prophylactic Vaccine Boost Against SARS-CoV-2 in Previously Vaccinated Healthy Elderly Adults.
Sep 2021–Nov 2022, United Kingdom
Preclinical
Unnamed
DreamTec Limited
Hong Kong Subunit Phase I (30)[259]
Development of a COVID19 Oral Vaccine Consisting of Bacillus Subtilis Spores Expressing and Displaying the Receptor Binding Domain of Spike Protein of SARS-COV2.
Apr–Dec 2021, Hong Kong
Preclinical
Almansour-001
Imam Abdulrahman Bin Faisal University, ICON plc
Ireland, Saudi Arabia DNA Phase I (30)[260]
Single center, randomized, observer blind, dosage finding.
Feb–Jul 2022, Ireland, Saudi Arabia
Preclinical
Unnamed
North's Academy of Medical Science Medical biology institute
North Korea Subunit (spike protein with Angiotensin-converting enzyme 2) Phase I–II (?)[261]
Jul 2020, North Korea
Preclinical
Vabiotech COVID-19 vaccine
Vaccine and Biological Production Company No. 1 (Vabiotech)
Vietnam Subunit Preclinical
Awaited for the conduct on Phase I trial.[262]
?
INO-4802
Inovio
United States DNA Preclinical
Awaited for the conduct on Phase I/II trials.[263]
?
Bangavax (Bancovid)[264][265]
Globe Biotech Ltd. of Bangladesh
Bangladesh RNA Preclinical
Awaiting for approval from Bangladesh government to conduct the first clinical trial.[266]
?
Unnamed
Indian Immunologicals, Griffith University[267]
Australia, India Attenuated Preclinical ?
EPV-CoV-19[268]
EpiVax
United States Subunit (T cell epitope-based protein) Preclinical ?
Unnamed
Intravacc[269]
Netherlands Subunit Preclinical ?
CureVac–GSK COVID-19 vaccine[270]
CureVac, GSK
Germany, United Kingdom RNA Preclinical ?
DYAI-100[271] Sorrento Therapeutics, Dyadic International, Inc.[272] United States Subunit Preclinical ?
Unnamed[273]
Ministry of Health (Malaysia), Malaysia Institute of Medical Research Malaysia, Universiti Putra Malaysia
Malaysia RNA Preclinical ?
CureVac COVID-19 vaccine (CVnCoV)
CureVac, CEPI
Germany RNA (unmodified RNA)[274] Terminated (44,433)[275][276][277][278][279]
Phase 2b/3 (39,693): Multicenter efficacy and safety trial in adults.
Phase 3 (2,360+180+1,200+1,000=4,740): Randomized, placebo-controlled, multicenter, some observer-blinded, some open-labeled.
Nov 2020 – Jun 2022, Argentina, Belgium, Colombia, Dominican Republic, France, Germany, Mexico, Netherlands, Panama, Peru, Spain[280]
Phase I–II (944)[281][282]
Phase I (284): Partially blind, controlled, dose-escalation to evaluate safety, reactogenicity and immunogenicity.
Phase IIa (660):Partially observer-blind, multicenter, controlled, dose-confirmation.
Jun 2020 – Oct 2021, Belgium (phase I), Germany (phase I), Panama (phase IIa), Peru (phase IIa)
Emergency (2)
CORVax12
OncoSec Medical, Providence Health & Services
United States DNA Terminated (36)[285]
Open-label, non-randomized, parallel assignment study to evaluate the safety of prime & boost doses with/without the combination of electroporated IL-12p70 plasmid in 2 age groups: 18-50 years-old and > 50 years-old.
Dec 2020 – Jul 2021, United States
Preclinical
Sanofi–Translate Bio COVID-19 vaccine (MRT5500)[286]
Sanofi Pasteur and Translate Bio
France, United States RNA Terminated (415)[287]
Interventional, randomized, parallel-group, sequential study consisting of a sentinel cohort followed by the full enrollment cohort. The sentinel cohort is an open-label, step-wise, dose-ranging study to evaluate the safety of 3 dose levels with 2 vaccinations. The full enrollment cohort is a quadruple-blinded study of safety and immunogenicity in 2 age groups, with half receiving a single injection, and the other half receiving 2 injections.
Mar 2021 – Sep 2021, Honduras, United States, Australia
Preclinical
AdCOVID
Altimmune Inc.
United States Viral vector Terminated (180)[288][289]
Double-blind, randomized, placebo-controlled, first-in-Human.
Feb 2021 – Feb 2022, United States
Preclinical
LNP-nCoVsaRNA[290]
MRC clinical trials unit at Imperial College London
United Kingdom RNA Terminated (105)
Randomized trial, with dose escalation study (15) and expanded safety study (at least 200)
Jun 2020 – Jul 2021, United Kingdom
?
TMV-083
Institut Pasteur
France Viral vector Terminated (90)[291]
Randomized, Placebo-controlled.
Aug 2020 – Jun 2021, Belgium, France
?
SARS-CoV-2 Sclamp/V451[292][293][unreliable source?]
UQ, Syneos Health, CEPI, Seqirus
Australia Subunit (molecular clamp stabilized spike protein with MF59) Terminated (120)
Randomised, double-blind, placebo-controlled, dose-ranging.
False positive HIV test found among participants.
Jul–Oct 2020, Brisbane
?
V590[294] and V591/MV-SARS-CoV-2[295] Merck & Co. (Themis BIOscience), Institut Pasteur, University of Pittsburgh's Center for Vaccine Research (CVR), CEPI United States, France Vesicular stomatitis virus vector[296] / Measles virus vector[297][unreliable source?] Terminated
In phase I, immune responses were inferior to those seen following natural infection and those reported for other SARS-CoV-2/COVID-19 vaccines.[298]
  1. ^ Latest Phase with published results.
  2. ^ Phase I–IIa in South Korea in parallel with Phase II–III in the US

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