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Nobel laureates

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After User:Highfly3442's edit today we have Six people have been awarded Nobel Prizes for direct and indirect studies of vitamin B12: George Whipple, George Minot and William Murphy (1934), Alexander R. Todd (1957), Dorothy Hodgkin (1964) and Robert Woodward (1965). As the citation makes clear, three of these (Todd, Hodgkin and Woodward) were awarded the prize for other work, not specifically on B12. Indeed, Woodward's synthesis work was not even published until 1973! I wonder if we should therefore reword that sentence to something like George Whipple, George Minot and William Murphy were awarded the Nobel Prize in 1934 for their work on the vitamin. Three other Nobel laureates, Alexander R. Todd (1957), Dorothy Hodgkin (1964) and Robert Woodward (1965) made important contributions to its study.(Same citation) Mike Turnbull (talk) 15:32, 19 November 2023 (UTC)[reply]

Michael D. Turnbull As the person who raised this to GA in 2020, I will not dispute your proposed change. David notMD (talk) 08:26, 20 November 2023 (UTC)[reply]
 Done Mike Turnbull (talk) 14:40, 20 November 2023 (UTC)[reply]
Thanks Michael.
I just noticed that you made the record straight.
Although I love Wiki, and have done a lot of editing,I am still learning when I can.
I find Wiki hard to really become proficient at. I don't see where there is clear training available, although there are a lot of articles that, if studied enough, one could succeed in mastery! Highfly3442 (talk) 15:11, 1 March 2024 (UTC)[reply]
@Highfly3442 There is not "training", except by doing but there is now a mentorship scheme that many new editors are offered and which was designed to aid editor retention. You can activate this at the bottom of Special:Preferences and then when you navigate to your userpage, you'll see a new tab with a number of features. I suggest you add a small bit about yourself so that you actually have a userpage: see WP:UPYES for guidance. Mike Turnbull (talk) 16:15, 1 March 2024 (UTC)[reply]

The amount of B12 absorbed by passive diffusion process

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Is there any data on the amount or ratio (percentage) of B12 absorbed by passive diffusion process. I understand that there may be different factors that may affect the passive diffusion absorption, still, is there any data? Maxim Masiutin (talk) 10:34, 25 March 2024 (UTC)[reply]

Maxim Masiutin Reference 12 cites some very old work that used radioactive cobalt "Adams and colleagues (1971) measured fractional absorption of radiolabeled cyanocobalamin and reported that nearly 50 percent was retained at a 1-µg dose, 20 percent at a 5-µg dose, and just over 5 percent at a 25-µg dose." This matches up with receptor-mediated absorption saturated at around 1-2 micrograms, with passive absorption being modest. The text goes on to estimate 1% passive absorption was observed with mega-doses. A PubMed search on vitamin B12 supplemention limited to clinical trials demonstrated that high doses increase plasma concentration. Examples: PMID 33513879 showed 1000 mcg/day for a year tripled plasma B12. After 500 ug/day for 8 weeks, plasma was at 340 compared to 180 for placebo. (PMID 23236022). David notMD (talk) 03:41, 27 March 2024 (UTC)[reply]
I think that it would be OK to cite these references. Could you please update the B12 article and add summary information on the amount or ratio (percentage) of B12 absorbed by passive diffusion process or if it is not known which share is absorbed by active transport and which by passive diffusion, at least specify percentage of B12 absorbed both ways, since the amount absorbed by active process is negligible. I think writing more about active transport and passive diffusion in the article of B12 is very important. I always considered these issues of absorption very important, especially for those vitamins which are poorly absorbed, such as B2 and B12.
@David notMD -- could you please update the B12 article with that information? Maxim Masiutin (talk) 09:04, 27 March 2024 (UTC)[reply]
Also, I read somewhere that 500 mcg once a month in intramuscular injection gives similar plasma B12 levels as daily oral consumption of 1000 mcg, but can't now find the source. Therefore, we can assume that 30*1000 = 30000 mcg orally is equivalent to 500 mcg intramuscular. Maxim Masiutin (talk) 09:07, 27 March 2024 (UTC)[reply]
Maxim Masiutin I will undertake rewriting and re-referencing the entire Absorption section, as it is too long, depends too much on ref #12, and the other refs are not appropriate (in vitro, old, a clinical trial, etc). The short Treatment section also needs improvement. I found PMID 36249776 and 30261596 as possible refs. Those and some other review articles on intramuscular describe that after initial frequent intramuscular treatment to treat deficiency, then either oral dosing at 1000 ug/day (with passive absorption estimated at 1%) or intramuscular dosing at 1000 ug once a month, or even every other month, are comparable for prevention of recurrence. David notMD (talk) 11:19, 27 March 2024 (UTC)[reply]
Yes, thank you, that was what I meant, suggesting that oral absorption is about 1/30 (3.33%) or 1/60 (1.67%) of the dose of 1000 mcg. Maxim Masiutin (talk) 11:49, 27 March 2024 (UTC)[reply]

Treatment subsection revised and two references added. Still need to address the Absorption section. David notMD (talk) 14:03, 28 March 2024 (UTC)[reply]

All of Absorption section replaced. Passive absorption described as roughly 1%. Treatment makes clear that intramuscular 1000 ug once per month versus oral, same amount daily. David notMD (talk) 21:12, 2 April 2024 (UTC)[reply]

Diagnosis needs work, too

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I recently added content at Haptocorrin (HC) that makes clear that functional B12 deficiency can be present even when serum B12 is elevated above the normal range. At issue is the fact that 80-90% of circulating B12 is bound to haptocorrin, and is thus unavailable to cell receptors for transobalamin II, the transport protein that does deliver B12 to cells. HC-B12 is described as circulating storage, but the means for disassociating the complex when needed are not entirely understood. Elevated HC, and thus elevated HC-B12 not available to cells, is caused by cancer, hematological diseases and liver diseases. Same content added here, to Diagnosis. David notMD (talk) 14:40, 31 March 2024 (UTC)[reply]

Significance of above-normal B-12 in blood test

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I skimmed the article, and higher blood test results did not seem well covered. While I was in the hospital I had a higher than normal level of B-12 a couple years ago in a blood test. 1600pg/ml. 232-1245 is normal range. I see in the previous talk section some of my confusion concerning what I have read. And in the diagnosis section of the article.

I stopped taking the high-dose (1000 mcg) sublingual weekly tablets I had been taking for years. Fellow paranoid vegetarians will understand why I was taking them to begin with. I was not fully vegetarian then or now. Though I was fully vegetarian at times before that, and that is where the B-12 supplementation was fully engaged. I have no idea if this blood level was a symptom of other health problems, or a cause of health problems, or both. The whole causation/correlation quandary. Anyway, I did as I was told by the doctors, and figured they were covering all the angles they knew about at the time.

The literature says it could be a symptom of some serious problems that require diagnosis. So that should be better covered in the article. And people should know more about the blood tests. Many people, myself included, had no idea that one could take too much B-12, or have too much in their blood. It's still not clear in a lot of the literature I see. And the previous talk section makes me even more confused.

See: 

What cancers cause high B12 levels?
Other studies focusing on specific cancers have shown a strong association between elevated B12 levels and liver cancers (OR 3.3 [95%CI: 1.1–10.4] for hepatocellular carcinomas and OR 4.7 [95%CI: 1.2–17.9] for other liver cancers) [16], a moderate association with prostate cancer (OR 1.1 [95%CI: 1.0–1.2]) [17], and no ...Feb 9, 2020

Strength of the Association of Elevated Vitamin B12 and Solid Cancers

Significance of elevated cobalamin (vitamin B12) levels in blood

That article lists similar articles after the abstract.

And I don't see anything in the article about how much better sublingual absorption is versus just swallowing a tablet. I don't know. I would like to know from some authoritative source. I would put the tablet between my gum and teeth, or under my tongue. Or alternate around my mouth until it slowly dissolved. If it is significantly better absorbed, then that could be a problem since one could be more easily getting too much B-12. On the other hand people who can't absorb it in their stomach, need to know what exactly is true, so that they can safely take the correct amount of B-12 if they need supplementation.

Another thing I didn't see in my skimming of the article: 

Unlike most other vitamins, B12 is stored in substantial amounts, mainly in the liver, until it is needed by the body. If a person stops consuming the vitamin, the body's stores of this vitamin usually take about 3 to 5 years to exhaust.

Vitamin B12 Deficiency - Disorders of Nutrition - Merck Manuals. 

People who eat a vegan diet and do not take vitamin B12 supplements or eat foods fortified with vitamin B12, are also at risk. Stores of vitamin B12 in the body can last around 2 to 5 years without being replenished, so it can take a long time for any problems to develop after a dietary change.

Vitamin B12 or folate deficiency anaemia - Causes - NHS.

--Timeshifter (talk) 17:35, 14 June 2024 (UTC)[reply]

Of the two refs you mention, Ermens et al 2003 PMID 14636871 is already in the article in the Diagnosis section as ref #55. The article text under-plays the potential importance of elevated blood B12 as a cancer marker or other disease marker. The second is Urbanski et al 2020 PMID 37050436, presenting the results of a large clinical trial (case control design) with results as your wrote = increased risk of some cancers.
There is some other literature. Liu et al 2024 PMID 38252787 reviewed the literature and reported that serum vitamin B12 concentration (>600 pmol/L) was associated with increased all-cause mortality. In contrast, Obeid 2022 PMID 36364737 concluded "Therefore, there is not sufficient evidence to assume that high plasma vitamin B12, high B12 intake, or treatment with pharmacological doses of vitamin B12, is causally related to cancer." Andres et al 2013 PMID 23447660 attributed elevated serum B12 to "solid neoplasms, haematological malignancies and liver and kidney diseases. This review reflects the potential importance of the vitamin B12 assay as an early diagnostic marker of these diseases."
I agree that this topic of elevated B12 deserves more content in the article, and to clarify whether high intake elevates serum concentration and disease risk, or if the diseases in question cause the elevated B12. David notMD (talk) 02:46, 15 June 2024 (UTC)[reply]
For those not familiar with PMID numbers, https://pubmed.ncbi.nlm.nih.gov/ is the site for the US Library of Medicine and a search on the PMID number will go to the article abstract. For some, the whole article is also free. David notMD (talk) 13:34, 15 June 2024 (UTC)[reply]

Efficacy of methylcobalamin

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I added a dubious tag to the section saying "the efficacy of methylcobalamin administration in treating vitamin B12 deficiency remains uncertain..." as two of the three given references don't seem to support there being significant doubt about MeCbl's efficacy versus other forms of B12, and the third still says it is beneficial. See more detail at Talk:Methylcobalamin#Treat B12 deficiency. Pagw (talk) 22:48, 7 February 2025 (UTC)[reply]

Pagw Do you feel comfortable that you can revise Vitamin B12 and Methylcobalamin to what in your opinon the references support? If yes, go ahead. David notMD (talk) 23:06, 7 February 2025 (UTC)[reply]
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