Talk:Triiodothyronine

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Molecular Biology: MCB

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Oppose merge

Oppose merge. Most of the information should remain in the thyroid hormone article, but it is useful to have this article in cases where the forms need to be distinguished. --Arcadian 03:17, 10 February 2007 (UTC)[reply]

Production Heading

I'm very concerned about the production heading, I really don't think that that's right. It has a biochemistry explanation that could be right (but doesn't look right and I don't have a textbook w/ me) and I think that a physiology explanation would be far more useful. A basic walk-through of the steps involved would probably do the casual reader a lot more justice. A3camero (talk) 01:14, 11 April 2008 (UTC)[reply]

Physiology

1) I- and Na+ symport, iodine secreted into colloid

2) Iodine added to thyroglobulin to make T3 and T4 in the colloid

3) Iodinated thyroglobulin is then taken back up by the cell

4) Enzymes chop the thyroglobulin into T3 and T4

5) T3 and T4 are excreted into plasma -> enter circulation

Triiodoliothyronine and Reverse T3

References to "reverse-T3" and "TriiodoLIOthyronine" would be much appreciated in this article. Also, if anyone knows whether standard T3 blood tests include reverse-T3 or not.

Geebee2K (talk) 02:50, 22 March 2011 (UTC)[reply]

It has a brief mention and links to its own page Reverse_triiodothyronine. The reverse-T3 is not a standard test in most locales neither is T3 and free-T3 it seems. In many cases of thyroid disease treatment only TSH and T4 is tested. If the condition is typical and the treatment works then it seems adequate. However in cases where the usual treatment regimes do not work to correct symptoms OR lab results further testing is prudent. Some progressive endocrinologists and unconstrained doctors do additionally test for some or all of T3, free-T3, free-T4, reverse-T3, TPO-, TG- and TSHR-antibodies to try and more accurately establish underlying causes and select and monitor treatment. The last four are generally more useful for diagnosis than treatment monitoring. Some of the tests are simply unavailable in some labs.

Idyllic press (talk) 12:44, 2 January 2025 (UTC)[reply]

Mechanism

The involvement of thyroid peroxidase in iodinating tyrosine explained on this page contradicts the mechanism on the thyroid peroxidase page. That page says that iodine released by TPO spontaneously binds to the tyrosine with no TPO intermediation.

173.25.54.191 (talk) 23:00, 6 March 2013 (UTC)[reply]

Synthesis of T4

The Synthesis of T4 section here says that Type I Deiodinase is responsible for 80% of the conversion of T4 to T3, and leaves it at that.

But the Iodothyronine_deiodinase#Types article claims that Type I Deiodinase is also capable of converting T4 into Reverse T3.

What's the scoop here?

--Rogermw (talk) 23:26, 15 November 2013 (UTC)[reply]