Jump to content

Talk:Transformer protein

Page contents not supported in other languages.
From Wikipedia, the free encyclopedia

There ain't no TFPs

[edit]

I got an impression this page was created by some type of automated data mining process. There are several problems with the result. Nobody except the author of OSU press-release (citation one) calls RfaH a "transformer". There are several terms and expression used to describe proteins that undergo substantial refolding, the one I prefer and which is widely used in professional publications is "metamorphic". No need to make up a new term, well, to borrow it from comics, I guess, especially since it is confusing - the term "transformer" (tra) is used in literature to denote key regulators of development (see 1: Siera SG, Cline TW. Sexual back talk with evolutionary implications: stimulation of the Drosophila sex-determination gene sex-lethal by its target transformer. Genetics. 2008 Dec;180(4):1963-81. PMID 18845845; PMC 2600935.). That's what you get by plugging "transformer" into Pubmed, not RfaH. I'd like to suggest taking this page down - its creation has been apparently triggered by a press-release, it contains only one relevant reference (the Cell paper, Burmann et al), and is poorly written. I would welcome an entry on protein fold metamorphism or on RfaH in particular, and would contribute to either one, but this one would need re-writing and re-naming. It's better just to put it out of its misery. — Preceding unsigned comment added by 216.165.126.125 (talk) 16:38, 27 September 2012 (UTC)[reply]