Talk:Theobald Smith

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Theobald Smith's Phenomenon or anaphylaxis was discovered by him through the use of guinea pigs which he injected with a small dose of blood serum containing diphtheria antitoxin. His experimenting with guinea pigs was conducted with the intention of determining a standardized or proper dose. He observed that a small dose of diphtheria antitoxin caused the guinea pigs to become highly susceptible to a somewhat larger dose of the same diphtheria antitoxin when injected several weeks later, perhaps causing the guinea pigs to die.

Other names for anaphylaxis include hypersusceptibility and protein sensitization.

141.151.176.221 00:05, 7 August 2005 (UTC)[reply]

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