Talk:Spinocerebellar ataxia

Work

As one can tell, this article could use a fair bit bit of work. Mainly it needs clearer a English description, written by somebody with medicial expertise, for those without it. Also, it needs a clearer or more practical definition of each type of SCA, including alternate any additional alternate names. I decided to make a single unified article, since many of the subtypes of SCA are so rare. --rob 10:34, 1 August 2005 (UTC)

Polyglutamine/ poly CAG

I took the liberty of doing a little update on the polyglutamine stuff. I also added the note, that you have an earlier onset with more radical symptoms with a longer CAG expansion. Actually, I work on spinocerebellar ataxias at the university (only SCA 1-4, 6 and 7).

Thanks. It's all greek to me. So, if you are familiar with this stuff, feel free to add/edit lots more. I've done my best to understand this, but it's really complicated. I only got interested due to knowing somebody with it. --rob 10:41, 16 August 2005 (UTC)

If that someone you know suffers from a SCA Type disease with a polyglutamine (poly CAG) expansion, you might want to watch for any news regarding "Trehalose". This is a disaccharid (double sugar, kind of), consisting of two glucose subunits. I think they put it in chewing gum or something like that. Anyway, in genetically engineered rats designed to develop Huntingtons disease (which is also caused by a poly CAG expansion) a trehalose based diet slowed onset and progression of symptoms. Okay, it was in rats and it was huntingtons disease, but I think it is worth keeping an eye on.

Thanks. I never heard of "Trehalose" before. I just found a few items with Google, and will read and monitor it. --rob 11:26, 17 August 2005 (UTC)

Incomplete

- SCA 15, 17, 18, 20 and 21 aren't even mentioned

- There are mistakes concerning critical clinical features (example: SCA 19 also causes mental reatardation, nystagmus and ataxia are almost universal among SCA-in the article they're not mentioned much, Machado Joseph very often has Parkinsonian features)

- Diseases that are now classed in the SCA family are missing (dentatorubral-pallidoluysian atrophy, episodic ataxias types 1-4, SCA with optic and cochleo-vestibular degeneration and OHAHA syndrome- ophthalmoplegia, hypoacusis, ataxia, hypotonia, athetosis)

I'll try to do a clean-up using as simple language as I can

Thanks for finding mistakes. Its great if you can fix them. If there's anything that's wrong, and you're not able to fix it right away, do feel free to remove it, to avoid displaying false information. --Rob 18:43, 30 March 2006 (UTC)

Categorisation

As there are so many disorders involving ataxia, a new category could be created to link them all, such as Category:hereditary ataxias or Category:Spinocerebellar ataxias. --apers0n 13:33, 16 September 2006 (UTC)

The use of < (less than) and > (greater than)

Article currently reads:

Average Onset (Range in Years) 4th decade (<10 to >60)

I make that (less than 10 years to greater than 60 years). Surely it should read:

Average Onset (Range in Years) 4th decade (>10 to <60)

Regards

Adam 129.67.66.34 11:13, 17 May 2007 (UTC)

Spinocerebellar atrophy grouped in this?

I thought there used to be an article on spinocerebellar atrophy in it's own right. I was under the impression that ataxia was more of a symptom, and atrophy possibly the cause. Is it common practice to group it under the name "spinocerebellar ataxia?" - Cyborg Ninja 17:31, 25 July 2007 (UTC)

spinocerebellar ataxia type 5

According to recent research by the University of Utah, type 5 is caused by "brittle" axons due to the malfunction in the production of beta spectrin protein. Add to page? [1] Jumping cheese 09:08, 18 August 2007 (UTC)

Go for it, particularly if you can find the original article. --Dpryan 18:08, 18 August 2007 (UTC)

I can't find the original paper. I tried using google scholar, but that didn't work. I'll have access to all scientific papers (hopefully even the most recent ones) when I figure out how to access them through the Cal website. Until then, I'll hold off. ^_^ Jumping cheese 06:17, 19 August 2007 (UTC)

You'll want to familiarize yourself with pubmed, which works a lot better than google scholar for these sorts of things. You can get the original paper here. It's open access. --Dpryan 20:15, 19 August 2007 (UTC)

Improvements on Spinocerebellar ataxia type 6

Studies found that a 60 year old patient in Japan diagnosed with Spinocerebellar ataxia type 6 had great improvements to her symptoms after taking a variety of 18 different Chinese herbs specifically taken for her gait disabilities. After nearly a year without the medication she reported ataxic gait dis-functions. After 60 days from the herbs, she reported great improvements to her ability to move. —Preceding unsigned comment added by 99.247.154.103 (talk) 02:15, 12 October 2010 (UTC)

Please take a look at WP:MEDRS. Looie496 (talk) 02:42, 12 October 2010 (UTC)

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