Talk:Sesame oil

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Uses / Cooking

Genereally, sesame oil is not used for frying as per indian cooking method. In southern India, coconut oil is widely used not sesame oil.

Out of the 4 south indan states of kerala, tamil nadu, andhra and karnataka, coconut oil is used for cooking only in kerala. In fact in kerala coconut oil is used for cooking and sesame is applied on hair but in tamil nadu it is exactly other way around - sesame for cooking and coconut for hair.J mareeswaran (talk) 19:49, 5 July 2008 (UTC)[reply]

Sesame oil also has good effects for growing hair it is taken through nose as per ancient way. "Also it has a good reputation for being safe to the heart just like Olive oil and Sun Flower oil. Because of this, it is ideally suited for deep frying." Is there a citation for this? —Preceding unsigned comment added by 99.231.89.235 (talk) 03:01, 12 October 2007 (UTC)[reply]

--Alright, removed the statement without a reference 74.121.14.242 —Preceding signed but undated comment was added at 03:09, 13 October 2007 (UTC)[reply]

Research papers given as references explain how cooking with sesame oil helps to fight blood pressure. Morever the Tamil name("good oil") for sesame oil gives an idea of the reputation of sesame oil. The following link explains this ^[1] J mareeswaran 05:01, 13 October 2007 (UTC)[reply]

-- That doesn't really answer my objection.. and I'm a little skeptical about the quality of the reference. —Preceding unsigned comment added by 99.231.89.235 (talk) 03:33, 18 October 2007 (UTC)[reply]

--- the objection needs to be more specifc. It is not clear what the objection is to... Is the objection to the statement that sesame oil is good for heart or is the objection to the clause that sesame oil has a reputation for being good to the heart, or is the objection to the statement that sesame is suited for deep frying? The following statement is taken from a purdue university research paper cited as reference in the main article:- "Sesame seed consumption appears to increase plasma gamma-tocopherol and enhanced vitamin E activity which are believed to prevent cancer and heart disease (Cooney et al. 2001)." J mareeswaran 20:02, 18 October 2007 (UTC)[reply]

^ http://www.idhayam.com/sesameoil/property.html

Nutritional value

Hello. I can see that the Nutritional Values numbers in the info-box is taken from the USDA database for "04058, Oil, sesame, salad or cooking". However, this source does not explain what kind of sesame oil was tested,which is crucial information. Was it a refined, semi-refined or a cold-pressed oil?

As some of the text in the article suggests, sesame oils may even vary from region to region and contain different amounts of nutrients. How different is "Indian sesame oil" to "ordinary sesame oil" for example? This article needs much better sourcing and explanation. RhinoMind (talk) 00:47, 18 August 2015 (UTC)[reply]

There is only one source of sesame oil identified in the USDA National Nutrient Database (salad or cooking oil) which I just added to the nutrient profile table. I am not aware of other reputable nutrient analyses that would provide reliable data for different preparations of sesame oil, requiring a source that is WP:RS. In my opinion, it would not matter much on actual nutrient values whether the oil is cold-pressed vs. refined or whatever, but rather taste and perhaps clarity of the sesame oil may be affected. --Zefr (talk) 01:19, 18 August 2015 (UTC)[reply]

P450 CYP inhibition

Thank you for pointing out that the studies were in vitro. However, there were at least one in vivo study. The inhibitory effect of sesame on CYP4F2 has been confirmed by a randomized, controlled crossover trial, where 33 overweight men and women consumed 25 grams per day of sesame for 5 weeks, resulting in a 28% decrease in plasma and a 32% decrease in urinary 20-HETE, while urinary sodium, potassium, and blood pressure were not affected. (PMID 19786646). CYP4F2 is a very important enzyme, is the only known enzyme to ω-hydroxylate Vitamin E (tocotrienols as well as tocopherols), thus making it a critical modulator of circulating plasma Vitamin E levels. It is also the main enzyme involved in production of 20-HETE. CYP4F2 affects the bioavailability of Vitamin K that, in turn, affects the dosing of Vitamin K antagonists such as warfarin, coumarin or acenocoumarol. Inappropriate doses of these drugs may lead to bleeding. The CYP4F2 enzyme also regulates bioactivation of various drugs, e.g. the anti-malarial drug pafuramidine and the anti-parasitic drug furamidine. That's why it is important to know that sesame seeds, especially when consumed daily in quantities about 25 grams or more, produce serious consequences on CYP4F2 and its metabolates. This can be aggravated in individuals carrying loss-of-function alleles in the CYP4F2 gene. Do you think that PMID 19786646 is a good quality source, suitable for Wikipedia? It's full-text is freely available at https://www.ahajournals.org/doi/pdf/10.1161/HYPERTENSIONAHA.109.139352

Here is the initial quote: "Research has shown that sesamin, a lignan found in sesame oil, inhibits the following cytochrome P450 enzymes in humans: CYP2C9^[1], CYP2D6,^[1] CYP3A4,^[2] CYP4F2^[3] and CYP4A11.^[3]"

-- Maxim Masiutin (talk) 19:52, 18 July 2020 (UTC)[reply]

This interpretation is all speculation from primary research, which is unreliable for encyclopedia medical content, shown as the lowest quality of evidence at WP:MEDASSESS (systematic reviews are needed; none exist for sesame oil). All but one of the sources are out of date, WP:MEDDATE, with no quality reviews published in recent years. Two sources are from unreliable journals - Pharmaceutics is not Medline-indexed (unreliable publishing history); Evidence-Based Complementary and Alternative Medicine is a quackery journal. The study in Hypertension is primary research, and 11 years old. None of this is useable for an encyclopedia. Zefr (talk) 22:10, 17 July 2020 (UTC)[reply]

References

^ ^a ^b Briguglio, M.; Hrelia, S.; Malaguti, M.; Serpe, L.; Canaparo, R.; Dell'Osso, B.; Galentino, R.; De Michele, S.; Dina, C. Z.; Porta, M.; Banfi, G. (2018). "Food Bioactive Compounds and Their Interference in Drug Pharmacokinetic/Pharmacodynamic Profiles". Pharmaceutics. 10 (4): 277. doi:10.3390/pharmaceutics10040277. PMC 6321138. PMID 30558213.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Lim, Y. P.; Ma, C. Y.; Liu, C. L.; Lin, Y. H.; Hu, M. L.; Chen, J. J.; Hung, D. Z.; Hsieh, W. T.; Huang, J. D. (2012). "Sesamin: A Naturally Occurring Lignan Inhibits CYP3A4 by Antagonizing the Pregnane X Receptor Activation". Evidence-Based Complementary and Alternative Medicine : Ecam. 2012: 242810. doi:10.1155/2012/242810. PMC 3356939. PMID 22645625.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ ^a ^b Wu, J. H.; Hodgson, J. M.; Clarke, M. W.; Indrawan, A. P.; Barden, A. E.; Puddey, I. B.; Croft, K. D. (2009). "Inhibition of 20-hydroxyeicosatetraenoic acid synthesis using specific plant lignans: In vitro and human studies". Hypertension (Dallas, Tex. : 1979). 54 (5): 1151–8. doi:10.1161/HYPERTENSIONAHA.109.139352. PMID 19786646. S2CID 207687898.

Vitamin K content

Carystus requested a citation for the vitamin K content in sesame oil. This value derives from the USDA FoodData Central entry presented and sourced in the article's nutrition table. Zefr (talk) 16:28, 10 September 2023 (UTC)[reply]

[1] ttp://www.idhayam.com/sesameoil/property.html

[pmid30558213-2] Briguglio, M.; Hrelia, S.; Malaguti, M.; Serpe, L.; Canaparo, R.; Dell'Osso, B.; Galentino, R.; De Michele, S.; Dina, C. Z.; Porta, M.; Banfi, G. (2018). "Food Bioactive Compounds and Their Interference in Drug Pharmacokinetic/Pharmacodynamic Profiles". Pharmaceutics. 10 (4): 277. doi:10.3390/pharmaceutics10040277. PMC 6321138. PMID 30558213.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[pmid22645625-3] Lim, Y. P.; Ma, C. Y.; Liu, C. L.; Lin, Y. H.; Hu, M. L.; Chen, J. J.; Hung, D. Z.; Hsieh, W. T.; Huang, J. D. (2012). "Sesamin: A Naturally Occurring Lignan Inhibits CYP3A4 by Antagonizing the Pregnane X Receptor Activation". Evidence-Based Complementary and Alternative Medicine : Ecam. 2012: 242810. doi:10.1155/2012/242810. PMC 3356939. PMID 22645625.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[pmid19786646-4] Wu, J. H.; Hodgson, J. M.; Clarke, M. W.; Indrawan, A. P.; Barden, A. E.; Puddey, I. B.; Croft, K. D. (2009). "Inhibition of 20-hydroxyeicosatetraenoic acid synthesis using specific plant lignans: In vitro and human studies". Hypertension (Dallas, Tex. : 1979). 54 (5): 1151–8. doi:10.1161/HYPERTENSIONAHA.109.139352. PMID 19786646. S2CID 207687898.

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