Talk:Second messenger system

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Wiki Education Foundation-supported course assignment

This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Ayun2.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 08:52, 17 January 2022 (UTC)[reply]

Untitled

Are the gases (NO and CO)really considered second messengers? It seems that in order for something to be a second messenger there needs to be a first messenger. --Dbrouse (talk) 06:33, 26 July 2008 (UTC)[reply]

Factual error: Neurotransmitters are not the only extracellular ligands that can induce a second messenger-mediated response. For example, glucagon is a hormone that incudes a cAMP response in, among other tissues, adipocytes, liver, and skeletal muscle. I propose that "neurotransmitters" be changed to "ligands such as neurotransmitters and hormones." --btangonan 10:23, 18, November 2008 (Pacific) —Preceding undated comment was added at 18:24, 18 November 2008 (UTC).[reply]

Reference and Example Section Improvements

Hi all,

Many of the references for this page are not found anymore. Providing better references may also improve the content via expanding on the provided examples.

The following articles and reviews seem to encompass a majority of the provided information and much more:

Sassone-Corsi P (December 2012). "The cyclic AMP pathway". review. Cold Spring Harbor Perspectives in Biology. 4 (12). doi:10.1101/cshperspect.a011148. PMC 3504441. PMID 23209152.

The above reference gives more information about the cAMP pathway that is used as an example. It is also a source that is published as an article, which "reviews" the pathway in general.

I would also like to talk about the epinephrine pathway. It is a good pathway that helps people understand how and where secondary messengers play a role, and it utilizes the stated examples.

Here is a paper that talks about the Inositol signaling pathway and how the other second messengers such as Ca2+ and DAG play a role, along with the end goal.

Yoshida Y, Imai S (June 1997). "Structure and function of inositol 1,4,5-trisphosphate receptor". review. Japanese Journal of Pharmacology. 74 (2): 125–37. doi:10.1254/jjp.74.125. PMID 9243320.

And lastly, the last example which involves the Histimine Pathway, the following paper helps understand the contribution of the second messenger.

Hanna VS, Hafez EA (May 2018). "Synopsis of arachidonic acid metabolism: A review". review. Journal of Advanced Research. 11: 23–32. doi:10.1016/j.jare.2018.03.005. PMC 6052663. PMID 30034873.

The papers also provide descriptions of how each secondary messenger plays its role and provides a better understanding of a second messenger in general.

Now, I understand this may be stepping foot into other wiki pages, so I will try my best to cite other pages if need be, along with utilizing the information provided in these reviews and articles.

Please let me know what you think about the idea, the papers I plan on utilizing, and any ideas that come to mind that can support this endeavor. Ayun2 (talk) 22:37, 10 October 2018 (UTC) — Preceding unsigned comment added by Ayun2 (talk • contribs) 23:29, 9 October 2018 (UTC)[reply]

Thanks for your suggestions. As these are all secondary source, review articles, and relevant to this article, I support their addition. Boghog (talk) 09:16, 3 December 2018 (UTC)[reply]