Talk:Saccharomyces boulardii

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Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Saccharomyces boulardii.

PubMed provides review articles from the past five years (limit to free review articles)
The TRIP database provides clinical publications about evidence-based medicine.
Other potential sources include: Centre for Reviews and Dissemination and CDC

Distinct strain?

Interesting article suggests S. boulardii is not a distinct strain:

Species identification and virulence attributes of Saccharomyces boulardii (nom. inval.). J Clin Microbiol. 1998 Sep;36(9):2613-7. McCullough MJ, Clemons KV, McCusker JH, Stevens DA.

from article: The results of the present study show that these S. boulardii strains are asporogenous strains of the species S. cerevisiae, not representatives of a distinct and separate species, and possess moderate virulence in murine models of systemic infection. Therefore, caution should be advised in the clinical use of these strains in immunocompromised patients until further study is undertaken.

Abstract.—Preceding unsigned comment added by Mfbabcock (talk • contribs)

This is an interesting topic...is S. boulardii really a separate species from S. cerevisiae?

McCullough MJ, Clemons KV, McCusker JH, Stevens DA (1998). "Species identification and virulence attributes of Saccharomyces boulardii (nom. inval.)". J. Clin. Microbiol. 36 (9): 2613–7. PMID 9705402.{{cite journal}}: CS1 maint: multiple names: authors list (link) (above)
van der Aa Kühle A, Jespersen L (2003). "The taxonomic position of Saccharomyces boulardii as evaluated by sequence analysis of the D1/D2 domain of 26S rDNA, the ITS1-5.8S rDNA-ITS2 region and the mitochondrial cytochrome-c oxidase II gene". Syst. Appl. Microbiol. 26 (4): 564–71. PMID 14666985.
Mitterdorfer G, Mayer HK, Kneifel W, Viernstein H (2002). "Clustering of Saccharomyces boulardii strains within the species S. cerevisiae using molecular typing techniques". J. Appl. Microbiol. 93 (4): 521–30. PMID 12234334.{{cite journal}}: CS1 maint: multiple names: authors list (link)
McFarland LV (1996). "Saccharomyces boulardii is not Saccharomyces cerevisiae". Clin. Infect. Dis. 22 (1): 200–1. PMID 8825013.

I think it merits further investigation and inclusion within the article. — Scientizzle 21:06, 11 January 2008 (UTC)[reply]

Cleanup time...

I've already started to clean this article up. It looks to me like it was written by a rep from a probiotic company...Additionally, I've had a difficult time locating some of the references listed in the article: they're not on PubMed the way they're cited, which concerns me. — Scientizzle 20:47, 11 January 2008 (UTC)[reply]

Interesting studies to consider including...

"Invasive infections due to Saccharomyces boulardii (Ultra-levure)". Prescrire Int. 16 (89): 110. 2007. PMID 17582930.
Herbrecht R, Nivoix Y (2005). "Saccharomyces cerevisiae fungemia: an adverse effect of Saccharomyces boulardii probiotic administration". Clin. Infect. Dis. 40 (11): 1635–7. doi:10.1086/429926. PMID 15889361.
Enache-Angoulvant A, Hennequin C (2005). "Invasive Saccharomyces infection: a comprehensive review". Clin. Infect. Dis. 41 (11): 1559–68. doi:10.1086/497832. PMID 16267727.
Szajewska H, Mrukowicz J (2005). "Meta-analysis: non-pathogenic yeast Saccharomyces boulardii in the prevention of antibiotic-associated diarrhoea". Aliment. Pharmacol. Ther. 22 (5): 365–72. doi:10.1111/j.1365-2036.2005.02624.x. PMID 16128673.
Burkhardt O, Köhnlein T, Pletz M, Welte T (2005). "Saccharomyces boulardii induced sepsis: successful therapy with voriconazole after treatment failure with fluconazole". Scand. J. Infect. Dis. 37 (1): 69–72. doi:10.1080/00365540510026454. PMID 15764194.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Johnston BC, Supina AL, Ospina M, Vohra S (2007). "Probiotics for the prevention of pediatric antibiotic-associated diarrhea". Cochrane Database Syst Rev (2): CD004827. doi:10.1002/14651858.CD004827.pub2. PMID 17443557.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Vandenplas Y, Salvatore S, Viera M, Devreker T, Hauser B (2007). "Probiotics in infectious diarrhoea in children: are they indicated?". Eur. J. Pediatr. 166 (12): 1211–8. doi:10.1007/s00431-007-0497-9. PMID 17611775.{{cite journal}}: CS1 maint: multiple names: authors list (link)
McFarland LV (2007). "Meta-analysis of probiotics for the prevention of traveler's diarrhea". Travel Med Infect Dis. 5 (2): 97–105. doi:10.1016/j.tmaid.2005.10.003. PMID 17298915.

I would propose in the "medical uses" section to cluster these uses by what has systemic reviews backing the claims and making more of a sub heading of those uses that are less supported by current data.Chickpecking (talk) 08:37, 6 December 2017 (UTC)[reply]

I agree that is sounds like a rep from a probiotic company. More of the specific biology, metabolism, and symbiotic relationship in the human gut would be useful for this organism. Has more medical uses than information about the actual organism. More pictures and things to describe S. boulardii would be useful. Thanks - Eleoni2002 (talk) 17:44, 2 September 2023 (UTC)[reply]

Availability varies extremely

In Germany Perenterol is standard medication against diarrhea, stocked in every pharmacy and prescribed by many physicians. When my daughter got sick in the UK, I researched the local brand name (DiarSafe), went to a pharmacy, went to another, and to a few more, and finally found out that it can only be ordered via the internet. (Nobody had ever heard of it or could find out how to order it.)

This is the kind of information that one needs before travelling, so it would be nice to have reliable sources that allow us to state something like this in the article. The closest thing I found is the following:

Saccharomyces boulardii is not readily available, but, for example, supplies of Perenterol Forte capsules (Saccharomyces boulardii 250mg) can be imported from a company called IDIS. Saccharomyces boulardii and Perenterol Forte are unlicenced in the UK, where Brewer’s yeast is classified as a health food supplement. - NHS Medicines Information - FAQ for healthcare professionals.

This source is also sceptical w.r.t. to efficacy. However, it is from 2005, and most studies showing efficacy seem to be more recent. [1] --Hans Adler (talk) 14:33, 10 December 2008 (UTC)[reply]

Efficiency comparing to lactobacillus

"It has been found to be more effective than the bacteria (lactobacillus) as a probiotic. [2]" - I checked the source 2 - it does not mention Saccharomyces boulardii at all. Something wrong with the reference? —Preceding unsigned comment added by Vaushev (talk • contribs) 12:37, 13 September 2009 (UTC)[reply]

Brands?

Would be nice to have a list of brands containing active cultures...--Xris0 (talk) 14:24, 12 June 2013 (UTC)[reply]

I agree that it would be good to have brands. the only one I know of is Florastor. Are there any others we know of so any potential list can be unbiased? --Maggletooth (talk) 17:55, 12 May 2014 (UTC)[reply]

I prescribe one called Gut Restore- from True BotanicaChickpecking (talk) 22:43, 11 December 2015 (UTC)[reply]

Do all brands have the same S.boulardii or are they slightly different boulardiis and efficacy has not been proven in some brands?

In Finland there is 5 brands as of 2017 December sold at university pharmacies:

Precosa. This brand is sold also in many other countries, the name may be different in some countries.
Boulardii Orion. A local Finnish brand.
YA maitohappobakteeri + S. boulardii. A local Finnish brand.
Sunwic 3 in 1.
Puhdas+ boulardii. A local Finnish brand.

These are the search results from 2 university pharmacies, the first one in Helsinki city, 2nd one in Kuopio city:

https://www.yliopistonapteekki.fi/catalogsearch/result/?q=boulardii

https://www.yliopistonverkkoapteekki.fi/epages/KYA.sf/fi_FI/?ViewAction=FacetedSearchProducts&SearchString=boulardii

ee1518 (talk) 11:12, 4 December 2017 (UTC)[reply]

Dosages

Because preparations of S. Boudarli are going to vary, would it not be more accurate to speak in terms of CFUs (colony forming units) instead of milligrams? These could probably located from studies and the labels on better brands of probiotics. — Preceding unsigned comment added by 108.34.178.240 (talk) 23:21, 26 December 2014 (UTC)[reply]