Talk:Podophyllotoxin

Mechanism of action

error in mechanism of action — Preceding unsigned comment added by 132.204.181.146 (talk) 22:56, 1 November 2013 (UTC)

Podophyllotoxin is dangerous

Savin (juniperus sabina aka sabina cacumina) oil is considered unsuitable for use in aromatherapy due to its podophyllotoxin content, which is cytoxic (destroys cells) -deaths have resulted from its use. Jester mclarpet (talk) 13:58, 16 September 2008 (UTC)

Biosynthesis is wrong

The diagram showing the biosynthetic pathway is error laden. The starting alcohol is missing a carbon, stereochemistry is all incorrect. I will try an upload a new image. FrustratedChemist (talk) — Preceding undated comment added 15:02, 23 February 2015 (UTC)

I have removed the image for now. If you need any help creating a new one, please just let me know. -- Ed (Edgar181) 15:06, 23 February 2015 (UTC)

I created a new one but it's very large. Any tips on scaling it down? FrustratedChemist (talk) — Preceding undated comment added 15:13, 23 February 2015 (UTC)

Thanks for creating the image. To adjust image width, you just need to specify a horizontal width ("600px") as I did with this edit. -- Ed (Edgar181) 15:25, 23 February 2015 (UTC)

Merger Proposal: moving Podophyllin to this page

The following discussion is closed. Please do not modify it. Subsequent comments should be made in a new section. A summary of the conclusions reached follows.

The result of this discussion was to **complete** the merge Tentrillion (talk) 13:55, 6 September 2015 (UTC)

---

I propose that Podophyllin be merged into Podophyllotoxin. I think that the content in the Podophyllin article can easily be explained in the context of Podophyllotoxin, and the Podophyllotoxin article is of a reasonable size that the merging of Podophyllin will not cause any problems as far as article size or undue weight is concerned. The original source of the Podophyllin article was the 1911 edition of Encycopedia Britannica. The primarily useful compound from podphyllin has been characterized and isolated since then, and it is Podophyllotoxin. — Preceding unsigned comment added by Tentrillion (talk • contribs) 23:06, 18 April 2015 (UTC)

The discussion above is closed. Please do not modify it. Subsequent comments should be made on the appropriate discussion page. No further edits should be made to this discussion.

Merger from Podophyllin

Article merged: See old talk-page here — Preceding unsigned comment added by Tentrillion (talk • contribs) 13:58, 6 September 2015 (UTC)

Historical use of Podophyllin

Was used as far back as the 19th century. https://www.google.co.uk/search?q=Podophyllin&num=100&safe=off&client=ubuntu&hs=E4r&channel=fs&biw=917&bih=582&tbm=bks&source=lnt&tbs=cdr:1,cd_min:1800,cd_max:1899&sa=X&ved=0ahUKEwiV4svh7tLOAhULXBoKHY5tBXQQpwUIFg&dpr=1.4

E.g.

Great Scott ! what a drench followed the swallowing of four pills, each containing a quarter of a grain of podophyllin. A charge of buckshot was not more deadly ; yet stout men praised their efficiency beyond measure.

All the best: Rich Farmbrough, 15:53, 21 August 2016 (UTC).

Qian Liu, Ying; Yang, Liu; Tian, Xuan (2007). "Podophyllotoxin: Current Perspectives". Current Bioactive Compounds. 3 (1): 37–66. doi:10.2174/157340707780126499. ISSN 1573-4072. might give also a good clue on the topic.

--Stone (talk) 15:04, 1 December 2020 (UTC)

Combine references

Hi,

Reference 17 and 18 are the same. Could anyone help to merge them?

Thanks, russ

 Done -- Ed (Edgar181) 22:07, 17 November 2016 (UTC)

Natural plant toxicity vs medical cream

I don't mean to be nuisance but this article seems to be more focused on talking about some medical cream instead of a plant toxin. I want to know what dangers exist with accidentally eating unripe mayapple fruit, not the medial issues associated with prostitution. Pretty much every other article about plant poisons talks about them the way they should. If I read the article on Solanine(the poison in green potatoes and potato leaves), the article isn't focused on some topical cream meant to treat Leprosy or something else. I know a lot of people suffer from STDs but their afflictions shouldn't be getting in the way of my desire to not die if I eat a fruit from a plant I'm planting. 2604:2D80:6305:600:21FF:8A5D:758:ED86 (talk) 21:03, 7 May 2023 (UTC)

The literature provides data that a dosage of around 0.3 to 0.6g can be fatal in adults, however there are very few cases of toxicity in the literature, and all of them are related to accidental ingestion of pharmaceutical products with high concentration of Podophyllin and are mostly for 70s and 80s.

Primary source, contains the link to other sources:

https://pmc.ncbi.nlm.nih.gov/articles/PMC7435106/

Lesser quality literature mentions that the ripe fruit is safe for consumption, but other parts of the plant would not be safe as they theoretically have higher concentrations of the toxin.

https://www.sciencedirect.com/science/article/pii/S2667142523001392

For now it's reasonable to say that the consumption of the fruits is safe due to the lack of cases reporting toxicity of it, but to say it with full scientific rigor that it is safe, a source with the chemical profile of the different parts of the plant would be needed. I did not find any but honestly didn't do a deep dive into the literature.

Honestly I think the article doesn't have a lot of information on this regard as the toxicity cases are very few and there's no reported case involving the fruit, while cases of Solanine toxicity are much more common and as such relevant to be more in-depth mentioned on the respective article. 197.211.242.122 (talk) 10:06, 6 February 2025 (UTC)