Talk:Pitavastatin

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Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Pitavastatin.

PubMed provides review articles from the past five years (limit to free review articles)
The TRIP database provides clinical publications about evidence-based medicine.
Other potential sources include: Centre for Reviews and Dissemination and CDC

grapefruit interactions with pitavastatin

This paragraph in the article could be made clearer: "Most statins are metabolised in part by one or more hepatic cytochrome P450 enzymes, leading to an increased potential for drug interactions and problems with certain foods (such as grapefruit juice). Pitavastatin appears to be a substrate of CYP2C9, and not CYP3A4 (which is a common source of interactions in other statins)"

What is not made clear is that the action of grapefruit involves the CYP3A4 cytochrome P enzyme. Since pitavastatin metabolism involves the CYP2C9 and not the CYP3A4, there is NO interaction believed between grapefruit juice and pitavastatin. And, by the way, this is also apparently the case for fluvastatin and rosuvastatin.

67.180.70.83 (talk) 15:59, 21 April 2010 (UTC)[reply]

Removed advertising

I am cropping this article to get rid of the worst advertising sections:

The section "Summary" is bad grammar, advertising, and contains no valuable information in addition to the other sections in my opinion. Unsourced.
"In addition, mild chronic kidney disease can be safely administered, as pitavastatin is excreted by kidney < 2%, the least in statins.". Simvastatin does not need lower doses in patients with moderate kidney disease as well, and that has 13% renal excretion.
Removed some WP:PEACOCK terms like "surprising" and "dramatically".

Additionally, the claim that pitavastatin seems to lead to less muscle side effects than other statins needs some clarification. How is that related to CoQ10? --ἀνυπόδητος (talk) 18:49, 19 November 2010 (UTC)[reply]