Talk:PDE6B

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This article was the subject of an educational assignment in Spring 2015. Further details were available on the "Education Program:Saint Louis University/Developmental Biology (Spring 2015)" page, which is now unavailable on the wiki.

Reference

1.Focus on molecules: rod cGMP phosphodiesterase type 6^[1]

2.Review: the history and role of naturally occurring mouse models with Pde6b mutations^[2]

3.Characteristics of photoreceptor PDE (PDE6): similarities and differences to PDE5.^[3]

References

^ Ionita, MA; Pittler, SJ (January 2007). "Focus on molecules: rod cGMP phosphodiesterase type 6". Experimental eye research. 84 (1): 1–2. PMID 16563379.
^ Han, J; Dinculescu, A; Dai, X; Du, W; Smith, WC; Pang, J (20 December 2013). "Review: the history and role of naturally occurring mouse models with Pde6b mutations". Molecular vision. 19: 2579–89. PMID 24367157.
^ Cote, RH (June 2004). "Characteristics of photoreceptor PDE (PDE6): similarities and differences to PDE5". International journal of impotence research. 16 Suppl 1: S28-33. PMID 15224133.

Peer Review 1

Hi Jiyao! It looks great to me! Here's a couple of thoughts I had:

Personally I think the "Function Section" might be able to be expanded? Especially because of the length of your "Animal Studies" section, I would think function would be of great importance?
I've heard that Wikipedia dislikes the "Further Reading" section and I deleted mine at the suggestion of Dr. Ogilvie so perhaps that would be good?
In your "Animal Studies section there are a few good opportunities you could take for Wikilinks such as "exon," "provirus," and "World War II?"
Something about the diction of your last sentence in the intro paragraph seems odd maybe, perhaps instead of saying "various kinds," "various types" could be better?
Holoenzyme may also need a Wikilink?

I hope these are okay, sorry there are so few suggestions but your page looks great! Mhirabay (talk) 13:51, 4 April 2015 (UTC)[reply]

Peer Review 2

For the sentence, "It is crucial in transmission and amplification of visual signal," explain what "It" refers to (the subunit or the gene), and perhaps visual signal should be plural (visual signals)?

Rephrase sentence, "The existence of this beta subunit is essential for the PDE6 to function normally," to "The existence of this beta subunit is essential for normal PDE6 functioning."

For the sentence, "The C-terminal interacts with membrane by isoprenylation and S-carboxylmethylation," explain what membrane you are referring to.

For the sentence, "The Rod cell PDE6 is a member of phosphodiesterase (PDE) family," do you mean "The rod cell's PDE6..."?

Maybe explain what you mean by, "PDE6B (this protein)..."

Reword, "After that the presnaptic transimitter is reduced." I would rephrase it for you, but I'm not sure if you mean "After that" as in after hyperpolarization. Also, is "reduced" the right expression for transmitters? Maybe "inactivated" works instead?

For the following sentence, "And then cGMP is restored by Guanylate cyclase, the channels reopen, which is called light adaption," rephrase to something like, "Next, Guanylate cyclase restores cGMP, which reopens the membrane channels. This process is called light adaptation."

This sentence is a fragment: "The possibility of altering the course of retinal degeneration through subretinal injection of recombinant replication defective adenovirus that contained the murine cDNA for wildtype beta-PDE."

Because you mention that Keeler discovered the retinal degeneration phenotype during WWII, does that scientific research have something to do specifically with the war?

Great job, Jiyao! It must have been a lot of work getting all the acronyms figured out, especially because they are all so similarly spelled. I also made some minor edits such as making some words plural, adding articles, and adding some punctuation. Mmilldev (talk) 01:53, 4 May 2015 (UTC)[reply]

[1] Ionita, MA; Pittler, SJ (January 2007). "Focus on molecules: rod cGMP phosphodiesterase type 6". Experimental eye research. 84 (1): 1–2. PMID 16563379.

[2] Han, J; Dinculescu, A; Dai, X; Du, W; Smith, WC; Pang, J (20 December 2013). "Review: the history and role of naturally occurring mouse models with Pde6b mutations". Molecular vision. 19: 2579–89. PMID 24367157.

[3] Cote, RH (June 2004). "Characteristics of photoreceptor PDE (PDE6): similarities and differences to PDE5". International journal of impotence research. 16 Suppl 1: S28-33. PMID 15224133.

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